(R)-6-(((5R,7R)-7-methyl-5,6,7,8-tetrahydroquinolin-5-yl)methyl)-5,6-dihydropyridin-2(1H)-one | 955126-95-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: (R)-6-(((5R,7R)-7-methyl-5,6,7,8-tetrahydroquinolin-5-yl)methyl)-5,6-dihydropyridin-2(1H)-one
• CAS: 955126-95-1
• 化学式: C₁₆H₂₀N₂O
• 分子量: 256.348
• InChiKey: IIHQVKWWHYLPMZ-JHJVBQTASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.58
• 重原子数：
  19.0
• 可旋转键数：
  2.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  41.99
• 氢给体数：
  1.0
• 氢受体数：
  2.0

反应信息

• 作为反应物：
  描述：

  (R)-6-(((5R,7R)-7-methyl-5,6,7,8-tetrahydroquinolin-5-yl)methyl)-5,6-dihydropyridin-2(1H)-one 在 palladium on activated charcoal 氢气 作用下， 以 乙酸乙酯 为溶剂， 反应 24.0h， 生成
  参考文献：
  名称：

  Asymmetric Total Syntheses of Two Phlegmarine-Type Alkaloids, Lycoposerramines-V and -W, Newly Isolated from Lycopodium serratum

  摘要：

  Two new Phlegmarine-type alkaloids, lycoposerramines-V and -W, were isolated from Lycopodium, serratum, and their structures including the absolute configuration were established by asymmetric total synthesis involving such key steps as Johnson-Claisen rearrangement, asymmetric allylation, and ring-closing metathesis (RCM)- or Sml(2)-mediated stereoselective piperidine ring construction.

  DOI：

  10.1021/ol701871v
• 作为产物：
  描述：

  2-[(5R,7R)-7-methyl-5,6,7,8-tetrahydroquinolin-5-yl]acetaldehyde 在 Grubbs catalyst first generation sodium azide 、 水 、 三乙胺 、 三苯基膦 作用下， 以 四氢呋喃 、 乙醚 、 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 41.5h， 生成 (R)-6-(((5R,7R)-7-methyl-5,6,7,8-tetrahydroquinolin-5-yl)methyl)-5,6-dihydropyridin-2(1H)-one
  参考文献：
  名称：

  Asymmetric Total Syntheses of Two Phlegmarine-Type Alkaloids, Lycoposerramines-V and -W, Newly Isolated from Lycopodium serratum

  摘要：

  Two new Phlegmarine-type alkaloids, lycoposerramines-V and -W, were isolated from Lycopodium, serratum, and their structures including the absolute configuration were established by asymmetric total synthesis involving such key steps as Johnson-Claisen rearrangement, asymmetric allylation, and ring-closing metathesis (RCM)- or Sml(2)-mediated stereoselective piperidine ring construction.

  DOI：

  10.1021/ol701871v