(1R,2R)-N,N'-bis[(2,4,6-triisopropylphenyl)methyl]-1,2-diaminocyclohexane | 1245908-09-1

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: (1R,2R)-N,N'-bis[(2,4,6-triisopropylphenyl)methyl]-1,2-diaminocyclohexane
• 英文别名: (1R,2R)-1-N,2-N-bis[[2,4,6-tri(propan-2-yl)phenyl]methyl]cyclohexane-1,2-diamine
• CAS: 1245908-09-1
• 化学式: C₃₈H₆₂N₂
• 分子量: 546.924
• InChiKey: SKKYRUQSWNFWNE-XPSQVAKYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  10.4
• 重原子数：
  40
• 可旋转键数：
  12
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.68
• 拓扑面积：
  24.1
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2,4,6-三异丙基苄氯 、 (1R,2R)-1,2-diaminocyclohexane 在 potassium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 6.0h， 以45%的产率得到(1R,2R)-N,N'-bis[(2,4,6-triisopropylphenyl)methyl]-1,2-diaminocyclohexane
  参考文献：
  名称：

  Asymmetric conjugate addition of α-keto esters to nitroolefins catalyzed by chiral CuII hydroxo complexes

  摘要：

  As a part of our research project on hard anion-late transition metal complexes as mild acid-base catalysts, we describe herein that Cu-II hydroxo complexes having chiral N-substituted-diaminocyclohexanes are mild and selective catalysts, which are applicable to the catalytic asymmetric conjugate addition of alpha-keto esters to nitroolefins. The reaction proceeded diastereoselectively without the detectable formation of self-aldol products, affording the corresponding coupling products with anti-stereochemistry in an enantioselective manner. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2010.04.009

文献信息

• Asymmetric conjugate addition of α-keto esters to nitroolefins catalyzed by chiral CuII hydroxo complexes
  作者：Ayako Nakamura、Sylvain Lectard、Ryo Shimizu、Yoshitaka Hamashima、Mikiko Sodeoka

  DOI：10.1016/j.tetasy.2010.04.009

  日期：2010.7

  As a part of our research project on hard anion-late transition metal complexes as mild acid-base catalysts, we describe herein that Cu-II hydroxo complexes having chiral N-substituted-diaminocyclohexanes are mild and selective catalysts, which are applicable to the catalytic asymmetric conjugate addition of alpha-keto esters to nitroolefins. The reaction proceeded diastereoselectively without the detectable formation of self-aldol products, affording the corresponding coupling products with anti-stereochemistry in an enantioselective manner. (C) 2010 Elsevier Ltd. All rights reserved.