3,3'-(2,3-Naphthylenedioxy)bis-2-naphthol bis(benzyl ether) | 131354-73-9

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 3,3'-(2,3-Naphthylenedioxy)bis-2-naphthol bis(benzyl ether)
• 英文别名: 2,3-bis[(3-phenylmethoxynaphthalen-2-yl)oxy]naphthalene
• CAS: 131354-73-9
• 化学式: C₄₄H₃₂O₄
• 分子量: 624.736
• InChiKey: YWVNIGQQLWAVEF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  11.89
• 重原子数：
  48.0
• 可旋转键数：
  10.0
• 环数：
  8.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  36.92
• 氢给体数：
  0.0
• 氢受体数：
  4.0

反应信息

• 作为反应物：
  描述：

  3,3'-(2,3-Naphthylenedioxy)bis-2-naphthol bis(benzyl ether) 在 palladium on activated charcoal 氢气 、 sodium hydride 、 caesium carbonate 作用下， 以 四氢呋喃 、 乙酸乙酯 、 N,N-二甲基甲酰胺 为溶剂， 25.0~80.0 ℃ 、303.98 kPa 条件下， 反应 19.0h， 生成 3,6,17,28,39,42-Hexaoxa-48-azaoctacyclo[42.3.1.07,16.09,14.018,27.020,25.029,38.031,36]octatetraconta-1(48),7,9,11,13,15,18,20,22,24,26,29,31,33,35,37,44,46-octadecaene
  参考文献：
  名称：

  Macroring-neutral molecule complexation. Synthesis of biconcave pyridino hosts, complex formation, and x-ray crystal structures of two inclusion compounds

  摘要：

  A series of pyridino macrocycles 1-3(a-e) incorporating rigid bi- and triaryl ether segments in different ring positions have been synthesized. The effect of incorporation of these building blocks into a given macroring framework on the host properties for uncharged-molecule inclusion has been studied. Symmetric 21-membered macrorings 1c, 1d, or 2c, 2d with tri-o-phenylene, tri-2,3-naphthylene, or mixed phenylene naphthylene ether units are efficient hosts in solid-state complexation of dipolar-aprotic and apolar guests such as nitro compounds and nitriles as well as DMF, DMSO, THF, dioxane, or benzene. X-ray analyses of the solid-state complexes of 1d with PhNO2 (1:1) and MeCN (1:1) have been studied. It is shown that the presence of the triaryl ether segment induces a biconcave nonequally sided host conformation suitable for guest inclusion. The packing characterizes the host-guest topologies of the two inclusion compounds to be of (H-bonded) cavitate-type for the MeCN case and of interstitial channel type for the PhNO2 case. A comparative discussion of the present and previous results support the interpretation of hemispherand preorganization for the new host structures.

  DOI：

  10.1021/jo00003a055
• 作为产物：
  描述：

  2,3-二溴萘 、 3-benzyloxynaphthalen-2-ol 在 copper(I) oxide 、 1,3-dimethyl-2-imidazolinone 作用下， 反应 46.0h， 以27%的产率得到3,3'-(2,3-Naphthylenedioxy)bis-2-naphthol bis(benzyl ether)
  参考文献：
  名称：

  Macroring-neutral molecule complexation. Synthesis of biconcave pyridino hosts, complex formation, and x-ray crystal structures of two inclusion compounds

  摘要：

  A series of pyridino macrocycles 1-3(a-e) incorporating rigid bi- and triaryl ether segments in different ring positions have been synthesized. The effect of incorporation of these building blocks into a given macroring framework on the host properties for uncharged-molecule inclusion has been studied. Symmetric 21-membered macrorings 1c, 1d, or 2c, 2d with tri-o-phenylene, tri-2,3-naphthylene, or mixed phenylene naphthylene ether units are efficient hosts in solid-state complexation of dipolar-aprotic and apolar guests such as nitro compounds and nitriles as well as DMF, DMSO, THF, dioxane, or benzene. X-ray analyses of the solid-state complexes of 1d with PhNO2 (1:1) and MeCN (1:1) have been studied. It is shown that the presence of the triaryl ether segment induces a biconcave nonequally sided host conformation suitable for guest inclusion. The packing characterizes the host-guest topologies of the two inclusion compounds to be of (H-bonded) cavitate-type for the MeCN case and of interstitial channel type for the PhNO2 case. A comparative discussion of the present and previous results support the interpretation of hemispherand preorganization for the new host structures.

  DOI：

  10.1021/jo00003a055

文献信息

• WEBER, EDWIN;KOHLER, HANS-JURGEN;REUTER, HANS, J. QRG. CHEM., 56,(1991) N, C. 1236-1242
  作者：WEBER, EDWIN、KOHLER, HANS-JURGEN、REUTER, HANS

  DOI：——

  日期：——