| 169119-78-2

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• CAS: 169119-78-2
• 化学式: C₂₇H₃₄O₃
• 分子量: 406.565
• InChiKey: IZDAGRCKSCXTLK-DBIMOSKASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.08
• 重原子数：
  30.0
• 可旋转键数：
  7.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.37
• 拓扑面积：
  46.53
• 氢给体数：
  1.0
• 氢受体数：
  3.0

反应信息

• 作为产物：
  描述：

  cyanomethyl 2-hydroxybenzoate 、 维生素A 在 potassium carbonate 作用下， 以 N,N-二甲基乙酰胺 为溶剂， 生成
  参考文献：
  名称：

  Synthesis and in vitro biological activity of retinyl polyhydroxybenzoates, novel hybrid retinoid derivatives

  摘要：

  A new hybrid derived from retinol was designed to improve the stability and anti-oxidant activity of retinol and also to add whitening properties besides its usual anti-aging properties. A variety of polyhydroxybenzoates of retinol were prepared either by base-catalysis or by direct esterification of retinol and screened for such desirable properties by analyzing the in vitro biological activity of the hybrids. Some of the retinol derivatives enhanced their thermal stability and decreased photosensitivity, and exhibited an activity in collagen synthesis similar to that of retinol. In addition, the retinyl gallate 6 showed higher activities in free radical scavenging and melanogenesis inhibition than retinol. Thus, owing to its excellent stabilities, retinyl gallate 6 may be conveniently used not only as an additive for cosmetics for prevention and improvement of skin aging and whitening but also as medicine for the treatment of skin troubles. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2008.11.028

文献信息

• Retinol derivatives and process for preparing same
  申请人：——

  公开号：US20040062781A1

  公开（公告）日：2004-04-01

  The present invention relates to a new retinyl retinoate, a process for preparing same, a new intermediate which is useful for preparing same, and a cosmetic composition comprising the retinyl retinoate as the active ingredient.

  本发明涉及一种新的视黄醇酯基维甲酸酯、其制备方法、一种用于制备该化合物的新中间体以及一种含有该视黄醇酯基维甲酸酯作为活性成分的化妆品组合物。
• Chart for evaluating skin color and its application to efficacy evaluation of anti-aging and skin lightening products
  申请人：Access Business Group International LLC

  公开号：US10184837B2

  公开（公告）日：2019-01-22

  The present invention relates to charts, stacks and methods for evaluating skin color of a mammalian subject. The chart may include a substrate and an indicia visible from a first side of the substrate that includes a plurality of images of mammalian skin tones having varying degrees of yellowness, wherein each indicia is correlated with an index value. Also, the present invention relates to packaged topical cosmetic products that include a skin chart as well as to methods for evaluating anti-aging and skin lightening products.

  本发明涉及用于评估哺乳动物肤色的图表、堆叠和方法。该图表可包括基底和从基底第一面可见的指示符，该指示符包括具有不同黄度的哺乳动物肤色的多个图像，其中每个指示符都与一个指数值相关联。此外，本发明还涉及包括皮肤图的包装外用化妆品，以及评估抗衰老和美白产品的方法。
• Cosmetic product with proof device
  申请人：Unilever Home & Personal Care USA, Division of Conopco, Inc.

  公开号：US20020182235A1

  公开（公告）日：2002-12-05

  A cosmetic product system is provided which includes a cosmetic composition for combating signs of aging, and a test device packaged with the composition. The device includes a mechanism for evaluating progress of the combat against the signs of aging occurring over a period of time within which the composition is applied to an area of skin being monitored.

  提供了一种化妆品系统，它包括一种用于抗衰老的化妆品组合物和一种与组合物包装在一起的测试装置。该装置包括一个机制，用于评估在将组合物涂抹到被监测的皮肤区域的一段时间内，抗衰老工作的进展情况。
• System and method for improving skin texture monitored with a proof device
  申请人：Unilever Home & Personal Care USA, Division of Conopco, Inc.

  公开号：US20030225345A1

  公开（公告）日：2003-12-04

  A cosmetic product system is provided which includes a cosmetic composition for improving skin texture, and a test device packaged with the composition. The device includes a mechanism for visualizing progressive improvement in texture imparted by the composition as the latter is applied over a period of time.

  提供了一种化妆品系统，它包括一种用于改善肤质的化妆品组合物和一种与组合物包装在一起的测试装置。该装置包括一个机构，用于观察组合物在使用一段时间后逐渐改善肤质的情况。
• Facial ruler device, method and kit
  申请人：Unilever Home & Personal Care USA, Division of Conopco, Inc.

  公开号：US20040264750A1

  公开（公告）日：2004-12-30

  A pore ruler for objectively measuring attributes of facial skin pores and methods of using same. The pore ruler device includes a scale having indicia of at least two different pore attributes captured in a medium, determined by the following steps: (i) Taking multiple photographs of multiple subjects; (ii) Sorting the photographs, thereby classifying them according to said pore attributes to obtain sorted data; (iii) Analyzing said sorted data; (iv) Selecting representative images from each bin, thereby creating a pore ruler scale; and (v) Validating said pore ruler scale by clinicians and consumers to show that consumers can distinguish pore attributes and correlate them with said scale. A cosmetic product system is also provided which includes a cosmetic composition for reducing the appearance of facial skin pores, and a pore ruler device packaged with the composition. A method for assessing pore attributes on the pore ruler scale, as well as of evaluating progress of the combat against the signs of pores occurring over a period of time within which the composition is applied to an area of skin being monitored is provided.

  一种用于客观测量面部皮肤毛孔属性的毛孔尺及其使用方法。毛孔尺装置包括一个刻度，刻度上有至少两种不同毛孔属性的指示符，这些毛孔属性通过以下步骤确定： (i) 拍摄多个对象的多张照片； (ii) 对照片进行分类，从而根据所述孔隙属性对照片进行分类，以获得分类数据； (iii) 分析所述分类数据； (iv) 从每个分区中选择有代表性的图像，从而创建孔隙标尺刻度；以及 (v) 由临床医生和消费者验证所述毛孔标尺刻度，以表明消费者能够区分毛孔属性并将其与所述刻度相关联。 还提供了一种化妆品产品系统，其中包括用于缩小面部皮肤毛孔外观的化妆品组合物，以及与组合物包装在一起的毛孔尺装置。还提供了一种方法，用于评估毛孔尺刻度上的毛孔属性，以及评估在将该组合物涂抹到被监测的皮肤区域的一段时间内，针对毛孔迹象所采取的防治措施的进展情况。