4-羟基-3-氨基苯甲酸盐酸盐 | 1571-65-9

• 物质功能分类: 有机原料 - 羧酸类化合物及衍生物
• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 4-羟基-3-氨基苯甲酸盐酸盐
• 中文别名: 3-氨基-4-羟基苯甲酸盐酸
• 英文名称: 3-amino-4-hydroxybenzoic acid hydrochloride
• 英文别名: 3-amino-4-hydroxy-benzoic acid ; hydrochloride；3-Amino-4-hydroxy-benzoesaeure; Hydrochlorid；3-amino-4-hydroxybenzoic acid;hydrochloride
• CAS: 1571-65-9
• 化学式: C₇H₇NO₃*ClH
• mdl: MFCD00210389
• 分子量: 189.598
• InChiKey: WHQWETPIAIQHFZ-UHFFFAOYSA-N

物化性质

• 熔点：
  275 °C (decomp)

计算性质

• 辛醇/水分配系数(LogP)：
  0.35
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  83.6
• 氢给体数：
  4
• 氢受体数：
  4

安全信息

• 安全说明：
  S26,S36
• 危险类别码：
  R36/37/38
• 海关编码：
  2922509090

SDS

Material Safety Data Sheet

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Section 1. Identification of the substance
Product Name: 3-Amino-4-hydroxybenzoic acid
Synonyms:

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Section 2. Hazards identification
Harmful by inhalation, in contact with skin, and if swallowed.
H302: Harmful if swallowed
H315: Causes skin irritation
H319: Causes serious eye irritation
H335: May cause respiratory irritation
P261: Avoid breathing dust/fume/gas/mist/vapours/spray
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present
and easy to do – continue rinsing

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Section 3. Composition/information on ingredients.
Ingredient name: 3-Amino-4-hydroxybenzoic acid
CAS number: 1571-65-9

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Section 4. First aid measures
Skin contact: Immediately wash skin with copious amounts of water for at least 15 minutes while removing
contaminated clothing and shoes. If irritation persists, seek medical attention.
Eye contact: Immediately wash skin with copious amounts of water for at least 15 minutes. Assure adequate
flushing of the eyes by separating the eyelids with fingers. If irritation persists, seek medical
attention.
Inhalation: Remove to fresh air. In severe cases or if symptoms persist, seek medical attention.
Ingestion: Wash out mouth with copious amounts of water for at least 15 minutes. Seek medical attention.

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Section 5. Fire fighting measures
In the event of a fire involving this material, alone or in combination with other materials, use dry
powder or carbon dioxide extinguishers. Protective clothing and self-contained breathing apparatus
should be worn.

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Section 6. Accidental release measures
Personal precautions: Wear suitable personal protective equipment which performs satisfactorily and meets local/state/national
standards.
Respiratory precaution: Wear approved mask/respirator
Hand precaution: Wear suitable gloves/gauntlets
Skin protection: Wear suitable protective clothing
Eye protection: Wear suitable eye protection
Methods for cleaning up: Mix with sand or similar inert absorbent material, sweep up and keep in a tightly closed container
for disposal. See section 12.
Environmental precautions: Do not allow material to enter drains or water courses.

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Section 7. Handling and storage
Handling: This product should be handled only by, or under the close supervision of, those properly qualified
in the handling and use of potentially hazardous chemicals, who should take into account the fire,
health and chemical hazard data given on this sheet.
Storage: Store in closed vessels, refrigerated.

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Section 8. Exposure Controls / Personal protection
Engineering Controls: Use only in a chemical fume hood.
Personal protective equipment: Wear laboratory clothing, chemical-resistant gloves and safety goggles.
General hydiene measures: Wash thoroughly after handling. Wash contaminated clothing before reuse.

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Section 9. Physical and chemical properties
Appearance: Not specified
No data
Boiling point:
Melting point: No data
Flash point: No data
Density: No data
Molecular formula: C7H7NO3
Molecular weight: 153.1

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Section 10. Stability and reactivity
Conditions to avoid: Heat, flames and sparks.
Materials to avoid: Oxidizing agents.
Possible hazardous combustion products: Carbon monoxide, nitrogen oxides.

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Section 11. Toxicological information
No data.

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Section 12. Ecological information
No data.

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Section 13. Disposal consideration
Arrange disposal as special waste, by licensed disposal company, in consultation with local waste
disposal authority, in accordance with national and regional regulations.

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Section 14. Transportation information
Non-harzardous for air and ground transportation.

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Section 15. Regulatory information
No chemicals in this material are subject to the reporting requirements of SARA Title III, Section
302, or have known CAS numbers that exceed the threshold reporting levels established by SARA
Title III, Section 313.

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SECTION 16 - ADDITIONAL INFORMATION
N/A

反应信息

• 作为反应物：
  描述：

  二硫化碳 、 4-羟基-3-氨基苯甲酸盐酸盐 在 potassium hydroxide 作用下， 以 乙醇 为溶剂， 反应 6.0h， 以68.7%的产率得到2-疏基苯并噁唑-5-羧酸
  参考文献：
  名称：

  2-(甲硫基)苯并[d]噁唑-5-羧酸及其用途

  摘要：

  本发明公开了一种2-（甲硫基）苯并[d]噁唑-5-羧酸及其用途，产品有下列方法制得：？3-硝基-4-羟基苯甲酸甲酯的合成；3-氨基-4-羟基苯甲酸的合成；2-巯基苯并[d]噁唑-5-羧酸的合成；2-(甲硫基)苯并[d]噁唑-5-羧酸的合成；测试结果表明，在（-2～0）V的电位范围内，2-（甲硫基）苯并[d]噁唑-5-羧酸的电致化学发光性能很稳定，且在水相中的发光强度比在有机相中有明显的增强。

  公开号：

  CN104086505B
• 作为产物：
  描述：

  3-硝基-4-羟基苯甲酸甲酯 在 盐酸 、 tin(II) chloride dihdyrate 作用下， 以 水 为溶剂， 反应 5.0h， 以89.6%的产率得到4-羟基-3-氨基苯甲酸盐酸盐
  参考文献：
  名称：

  2-(甲硫基)苯并[d]噁唑-5-羧酸及其用途

  摘要：

  本发明公开了一种2-（甲硫基）苯并[d]噁唑-5-羧酸及其用途，产品有下列方法制得：？3-硝基-4-羟基苯甲酸甲酯的合成；3-氨基-4-羟基苯甲酸的合成；2-巯基苯并[d]噁唑-5-羧酸的合成；2-(甲硫基)苯并[d]噁唑-5-羧酸的合成；测试结果表明，在（-2～0）V的电位范围内，2-（甲硫基）苯并[d]噁唑-5-羧酸的电致化学发光性能很稳定，且在水相中的发光强度比在有机相中有明显的增强。

  公开号：

  CN104086505B

文献信息

• Preparation of 3-amino-4-hydroxybenzoic acids
  申请人：The Dow Chemical Company

  公开号：US04835306A1

  公开（公告）日：1989-05-30

  This invention is a process for the preparation of a 3-amino-4-hydroxybenzoic acid which comprises (a) contacting a p-halobenzoic acid with nitric acid in an acidic reaction medium under conditions such that a 3-nitro-4-halobenzoic acid is prepared; (b) contacting the 3-nitro-4-halobenzoic acid with an alkali metal hydroxide in a reaction medium under conditions such that the halo moiety is replaced with a hydroxide moiety, to prepare a 3-nitro-4-hydroxybenzoic acid, or salt thereof; and (c) reducing the 3-nitro-4-hydroxybenzoic acid under conditions such that a 4-hydroxy-3-aminobenzoic acid is prepared.

  这项发明涉及一种制备3-氨基-4-羟基苯甲酸的方法，包括(a)在酸性反应介质中将对卤苯甲酸与硝酸接触，条件下制备3-硝基-4-卤苯甲酸；(b)在反应介质中将3-硝基-4-卤苯甲酸与碱金属氢氧化物接触，条件下卤基被羟基取代，制备3-硝基-4-羟基苯甲酸或其盐；以及(c)在条件下还原3-硝基-4-羟基苯甲酸，制备4-羟基-3-氨基苯甲酸。
• Preparation of aromatic heterocyclic polymers
  申请人：THE DOW CHEMICAL COMPANY

  公开号：EP0247856A2

  公开（公告）日：1987-12-02

  Heterocyclic aromatic polymers are rapidly formed by contacting one or more appropriate multifunctional aromatic monomers, such as a diaminobenzenediol, a terephthaloyl halide and/or an aminohydroxybenzoic acid, with a sulfonic acid, as the solvent, and a dehydrating agent.

  将一种或多种适当的多功能芳香族单体（如二氨基苯二酚、对苯二甲酰卤和/或氨基羟基苯甲酸）与磺酸（作为溶剂）和脱水剂接触，可快速形成杂环芳香族聚合物。
• LIQUID CRYSTALLINE POLY(2,6-BENZOTHIAZOLE) COMPOSITIONS, PROCESS AND PRODUCTS
  申请人：SRI INTERNATIONAL

  公开号：EP0119202A1

  公开（公告）日：1984-09-26
• EP0119271A4
  申请人：——

  公开号：EP0119271A4

  公开（公告）日：1985-07-01
• LIQUID CRYSTALLINE POLYMER COMPOSITIONS, PROCESS, AND PRODUCTS
  申请人：SRI INTERNATIONAL

  公开号：EP0119192A1

  公开（公告）日：1984-09-26