S-Propargylcystein | 3262-64-4

• 物质功能分类: 有机原料 - 羧酸类化合物及衍生物
• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: S-Propargylcystein
• 英文别名: 2-azaniumyl-3-prop-2-ynylsulfanylpropanoate
• CAS: 3262-64-4
• 化学式: C₆H₉NO₂S
• 分子量: 159.209
• InChiKey: JAKVEOCMEMGHGB-UHFFFAOYSA-N

物化性质

• 熔点：
  176-178 °C (decomp)
• 沸点：
  294.8±40.0 °C(Predicted)
• 密度：
  1.284±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -2.6
• 重原子数：
  10
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  88.6
• 氢给体数：
  2
• 氢受体数：
  4

安全信息

• 海关编码：
  2930909090
• 危险性防范说明：
  P261,P305+P351+P338
• 危险性描述：
  H302,H315,H319,H335

文献信息

• USE OF ALLYLCYSTEINE OR ITS ANALOGS AND PHARMACEUTICAL COMPOSITION THREROF
  申请人：Fudan University

  公开号：EP2186512A1

  公开（公告）日：2010-05-19

  The invention discloses a use of compound S-allyl cysteine or its analogues in preparation of medicaments for preventing or treating myocardial injury and a preparation method thereof, as well as a pharmaceutical composition comprising the compound.

  该发明揭示了利用复合S-烯丙基半胱氨酸或其类似物制备用于预防或治疗心肌损伤的药物以及其制备方法，以及包含该化合物的药物组合物。
• Method Of Synthesizing S-Allyl-Cysteine Analogues And Their Therapeutic Application In Treating Myocardial Infarction
  申请人：ZHU YIZHUN

  公开号：US20090036534A1

  公开（公告）日：2009-02-05

  A pharmaceutical composition and methods of producing and application of the composition for treating myocardial infarction of a subject are disclosed. The pharmaceutical composition comprises a therapeutically effective amount of at least one synthesized compound selected from the group consisting of SEC, SPC, SBC, SPEC, SAC, SAMC, and SPRC, and a pharmaceutically acceptable carrier.

  揭示了一种用于治疗受试者心肌梗死的药物组合物及其制备和应用方法。该药物组合物包括从SEC、SPC、SBC、SPEC、SAC、SAMC和SPRC等化合物组合中选择的至少一种合成化合物的治疗有效量，以及一种药用可接受的载体。
• PREPARATION OF FUNCTIONALIZED POLYPEPTIDES, PEPTIDES, AND PROTEINS BY ALKYLATION OF THIOETHER GROUPS
  申请人：The Regents of the University of California

  公开号：US20150057433A1

  公开（公告）日：2015-02-26

  Reagents are disclosed for chemoselective tagging of methionine residues in peptides and polypeptides, subsequent bioorthogonal tag functionalization, and cleavage of the tags when desired to regenerate unmodified samples. This method compliments other peptide tagging strategies and adds capability for tag removal, which may be useful for release of therapeutic peptides from a carrier, or release of tagged protein digests from solid supports.

  本文披露了一种针对肽和多肽中蛋氨酸残基的化学选择性标记试剂，随后进行生物正交标记功能化，并在需要时剥离标记以再生未修饰样品的方法。该方法补充了其他肽标记策略，并增加了标记去除的能力，这可能对于从载体中释放治疗性肽或从固体支持中释放标记蛋白消化物是有用的。
• PREPARATION METHOD FOR 2-AMINO-3-SUBSTITUTED MERCAPTOPROPIONATE DERIVATIVE AND USE THEREOF
  申请人：Jiangsu Tasly Diyi Pharmaceutical Co., Ltd.

  公开号：EP3470408A1

  公开（公告）日：2019-04-17

  The present invention relates to a S-substituted-2-amino-3-mercaptopropionate derivative, a preparation method and an application thereof. The S-substituted-2-amino-3-mercaptopropionate derivative in the present invention has a structure of a formula (A). The present invention also includes an application of the S-substituted-2-amino-3-mercaptopropionate derivative serving as a medicine for treating and/or preventing neurodegenerative diseases, particularly Alzheimer's disease.

  本发明涉及一种 S-取代-2-氨基-3-巯基丙酸酯衍生物及其制备方法和应用。 本发明中的 S-取代-2-氨基-3-巯基丙酸酯衍生物具有式（A）的结构。 本发明还包括 S-取代-2-氨基-3-巯基丙酸酯衍生物作为治疗和/或预防神经退行性疾病，特别是阿尔茨海默病的药物的应用。
• S-substituted-2-amino-3-mercaptopropionate derivative, preparation method and application thereof
  申请人：JIANGSU TASLY DIYI PHARMACEUTICAL CO., LTD.

  公开号：US11149016B2

  公开（公告）日：2021-10-19

  The present invention relates to a S-substituted-2-amino-3-mercaptopropionate derivative, a preparation method and an application thereof. The S-substituted-2-amino-3-mercaptopropionate derivative in the present invention has a structure of a formula (A). The present invention also includes an application of the S-substituted-2-amino-3-mercaptopropionate derivative serving as a medicine for treating and/or preventing neurodegenerative diseases, particularly Alzheimer's disease.

  本发明涉及一种 S-取代-2-氨基-3-巯基丙酸酯衍生物及其制备方法和应用。本发明中的 S-取代-2-氨基-3-巯基丙酸酯衍生物具有式（A）的结构。本发明还包括S-取代-2-氨基-3-巯基丙酸酯衍生物作为治疗和/或预防神经退行性疾病，特别是阿尔茨海默病的药物的应用。