4-methoxy-quinoline; hydrochloride | 77523-51-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 4-methoxy-quinoline; hydrochloride
• 英文别名: 4-Methoxy-chinolin; Hydrochlorid；4-Methoxyquinoline hydrochloride；4-methoxyquinoline;hydrochloride
• CAS: 77523-51-4
• 化学式: C₁₀H₉NO*ClH
• 分子量: 195.648
• InChiKey: NMQXWWXRIDYHDV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.67
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  22.1
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4-methoxy-quinoline; hydrochloride 在 一水合肼 作用下， 以 乙醇 为溶剂， 生成 4-(benzylidenehydrazinyl)quinoline hydrochloride
  参考文献：
  名称：

  A new and potent class of quinoline derivatives against cancer

  摘要：

  A new class of 4-quinolinylhydrazone derivatives has been synthesized and evaluated for their cytotoxic potential against three cancer cell lines using the MTT assay. Compounds displaying more than 90 % of growth inhibition were evaluated for in vitro anticancer activities against four human cancer cell lines. The results were expressed as the concentrations that induce 50 % inhibition of cell growth (IC50) in mu g/cm(3). These compounds exhibited good cytotoxic activity against at least three cancer cell lines, with IC50 values between 0.314 and 4.65 mu g/cm(3). These derivatives are useful starting points for further study for new anticancer drugs and confirm the potential of quinoline derivatives as lead compounds in anticancer drug discovery.

  DOI：

  10.1007/s00706-015-1570-0
• 作为产物：
  描述：

  4,7-二氯喹啉 在 palladium 10% on activated carbon 、 氢气 、 sodium methylate 作用下， 以 甲醇 为溶剂， 反应 6.0h， 生成 4-methoxy-quinoline; hydrochloride
  参考文献：
  名称：

  A new and potent class of quinoline derivatives against cancer

  摘要：

  A new class of 4-quinolinylhydrazone derivatives has been synthesized and evaluated for their cytotoxic potential against three cancer cell lines using the MTT assay. Compounds displaying more than 90 % of growth inhibition were evaluated for in vitro anticancer activities against four human cancer cell lines. The results were expressed as the concentrations that induce 50 % inhibition of cell growth (IC50) in mu g/cm(3). These compounds exhibited good cytotoxic activity against at least three cancer cell lines, with IC50 values between 0.314 and 4.65 mu g/cm(3). These derivatives are useful starting points for further study for new anticancer drugs and confirm the potential of quinoline derivatives as lead compounds in anticancer drug discovery.

  DOI：

  10.1007/s00706-015-1570-0