N-(6-aminohexyl)-5-(1,2-dithiolan-3-yl)pentanamide | 66592-69-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二硫杂环戊烷
• 英文名称: N-(6-aminohexyl)-5-(1,2-dithiolan-3-yl)pentanamide
• 英文别名: N-(6-aminohexyl)-5-(dithiolan-3-yl)pentanamide
• CAS: 66592-69-6
• 化学式: C₁₄H₂₈N₂OS₂
• 分子量: 304.521
• InChiKey: DXENRGRQHAXLBZ-UHFFFAOYSA-N

物化性质

• 沸点：
  499.6±28.0 °C(Predicted)
• 密度：
  1.074±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  19
• 可旋转键数：
  11
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.93
• 拓扑面积：
  106
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  1-phenyl-2,5,8,11-tetraoxatridecan-13-oic acid 、 N-(6-aminohexyl)-5-(1,2-dithiolan-3-yl)pentanamide 在 4-二甲氨基吡啶 、 aluminum (III) chloride 、 1-羟基苯并三唑 、 N,N-二甲基苯胺 、 N,N'-二环己基碳二亚胺 作用下， 以 二氯甲烷 为溶剂， 反应 5.0h， 生成 DHAP
  参考文献：
  名称：

  Creating Protein-Imprinted Self-Assembled Monolayers with Multiple Binding Sites and Biocompatible Imprinted Cavities

  摘要：

  Imprinted monolayers have several advantages over bulk imprinted polymers such as excellent mass transfer of molecules into and out of imprinted sites and transduction of binding signals detected in real time. Protein-imprinted self-assembled monolayers (SAMs) were created with multiple binding sites and biocompatible imprinted cavities from functional thiols and novel disulfide compounds containing an oligoethylene glycol (OEG) terminal moiety and two amide groups incorporated in the chain (DHAP) in a biologically benign solution. DHAP played an important role in the formation of multiple binding sites and biocompatible cavities in addition to resisting nonspecific protein binding. The created protein-imprinted SAMs exhibited the excellent ability of specific binding of target proteins determined by multiple binding sites and imprinted cavities. The strategy generates tailor-made monolayer surfaces with specific protein binding and opens the possibility of controlled assembly of intellectual biomaterials and preparation of biosensors.

  DOI：

  10.1021/ja402423r
• 作为产物：
  描述：

  1,6-己二胺 、 Thioctic acid 在 (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate 作用下， 以 二氯甲烷 为溶剂， 反应 1.5h， 生成 N-(6-aminohexyl)-5-(1,2-dithiolan-3-yl)pentanamide
  参考文献：
  名称：

  烟酸衍生物,其制备方法及其药物组合物

  摘要：

  本发明涉及合成一系列烟酸杂联体及衍生物。结构式如式(I)所示。本发明还提供上述药物组合物的制备，并用于降低血脂、防治动脉粥样硬化、降低心脑血管事件风险药物中的应用，及其他氧化应激参与的神经保护药物中的应用。

  公开号：

  CN102532114B

文献信息

• [EN] ANTIOXIDANT, NEUROPROTECTIVE AND ANTINEOPLASTIC NANOPARTICLES COMPRISING A THERAPEUTIC AGENT ON AN AMPHIPHILIC SPACER OR AN AMPHIPHILIC POLYMER<br/>[FR] NANOPARTICULES ANTIOXYDANTES, NEUROPROTECTRICES ET ANTINÉOPLASIQUES COMPRENANT UN AGENT THÉRAPEUTIQUE SUR UN ESPACEUR AMPHIPHILE OU UN POLYMÈRE AMPHIPHILE
  申请人：CEDARS SINAI MEDICAL CENTER

  公开号：WO2013016696A1

  公开（公告）日：2013-01-31

  This invention relates to antioxidant, neuroprotective and antineoplastic nanoparticles comprising a therapeutic agent on an amphiphilic spacer or an amphiphilic polymer. Methods of synthesizing the antioxidant derivatives of camptothecin and antioxidant derivatives of camptothecin analogs, NSAIDs and statins, spontaneous emulsification or nanoprecipitation thereof to produce antioxidant, neuroprotective and anti-neoplastic nanoparticles comprising a therapeutic agent on an amphiphilic spacer or an amphiphilic polymer and their use in treating cancerous diseases are also provided. A further aspect of this invention is the use of these neuroprotective and anti-neoplastic nanoparticles for the preparation of delivery devices of other pharmaceuticals and/or drugs.

  本发明涉及抗氧化剂、神经保护剂和抗肿瘤纳米粒子，其包括具有治疗剂的两性亲脂间隔物或两性亲脂聚合物。还提供了合成伯氨替芬的抗氧化剂衍生物和伯氨替芬类似物、NSAIDs和他汀类药物的抗氧化剂衍生物的方法，以及通过自发乳化或纳米沉淀制备这些抗氧化、神经保护和抗肿瘤纳米粒子，其包括具有治疗剂的两性亲脂间隔物或两性亲脂聚合物，并且它们在治疗癌症疾病中的应用。本发明的另一个方面是利用这些神经保护和抗肿瘤纳米粒子制备其他药物和/或药物的输送装置。
• EP0149654A4
  申请人：——

  公开号：EP0149654A4

  公开（公告）日：1988-05-10
• DETECTING AGENT CARRYING POLYMER HAVING MULTIPLE UNITS OF VISUALIZATION MONOMER
  申请人：YALE UNIVERSITY

  公开号：EP0149654A1

  公开（公告）日：1985-07-31
• METHODS AND COMPOSITIONS FOR AMPLIFYING A DETECTABLE SIGNAL
  申请人：Great Basin Scientific

  公开号：EP2225398A2

  公开（公告）日：2010-09-08
• METHODS AND COMPOSITIONS FOR SIGNAL ENHANCEMENT USING MULTIVALENT INTERACTIONS
  申请人：Great Basin Scientific

  公开号：EP2225561A2

  公开（公告）日：2010-09-08