3-(2-dimethylaminomethyl-1-hydroxy-cyclohexyl)-phenyl 2-(4-isobutyl-phenyl)-propionate | 269079-66-5

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: 3-(2-dimethylaminomethyl-1-hydroxy-cyclohexyl)-phenyl 2-(4-isobutyl-phenyl)-propionate
• 英文别名: [3-[2-[(Dimethylamino)methyl]-1-hydroxycyclohexyl]phenyl] 2-[4-(2-methylpropyl)phenyl]propanoate
• CAS: 269079-66-5
• 化学式: C₂₈H₃₉NO₃
• 分子量: 437.623
• InChiKey: HPUAIJLEUZEGSX-UHFFFAOYSA-N

物化性质

• 沸点：
  564.8±45.0 °C(Predicted)
• 密度：
  1.069±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  6.2
• 重原子数：
  32
• 可旋转键数：
  9
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  49.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  Carbonyldiimidazole 、 布洛芬 、 O-去甲曲马多 在 sodium hydroxide 作用下， 以 四氢呋喃 、 二氯甲烷 、 水 、 mineral oil 为溶剂， 生成 3-(2-dimethylaminomethyl-1-hydroxy-cyclohexyl)-phenyl 2-(4-isobutyl-phenyl)-propionate
  参考文献：
  名称：

  Esters derived from substituted phennyl-cyclohexyl compounds

  摘要：

  新的酯类衍生物是从替代苯基环己基化合物中得到的，这些化合物是从曲马多中得到的。本发明还涉及获得这些化合物的方法以及它们用于制备具有镇痛性能的药物的用途。这些新的化合物的一般式（I）具有比曲马多更高的镇痛活性、更低的毒性和更长的有效时间。

  公开号：

  US06455585B1

文献信息

• Novel esters derived from (rr,ss)-2-hydroxybenzoate of 3-(2-dimethylaminomethyl-1-hydroxycyclohexyl)phenyl
  申请人：——

  公开号：US20030100598A1

  公开（公告）日：2003-05-29

  New esters derived from substituted phenyl-cyclohexyl compounds, which are derived from Tramadol, process for obtaining them and their use for preparing a drug with analgesic properties. These new compounds of general formula (I) have a higher analgesic activity, a lower toxicity and a longer effective time period than Tramadol.

  新的酯类化合物来源于取自曲马多（Tramadol）的取代苯基-环己基化合物，其制备方法以及它们用于制备具有镇痛性质的药物。这些新化合物的通式（I）具有比曲马多更高的镇痛活性，更低的毒性和更长的有效时间。
• NEW ESTERS DERIVED FROM SUBSTITUTED PHENYL-CYCLOHEXYL COMPOUNDS
  申请人：VITA-INVEST, S.A.

  公开号：EP1127871A1

  公开（公告）日：2001-08-29

  New csters derived from substituted phenyl cyclohexyl compounds, which are derived from Tramadol, process for obtaining them and their use for preparing a drug with analgesic properties. These new compounds of general formula (I) have a higher analges activcity, a lower toxicity and a longer effective time period than Tramadol.

  从曲马多衍生的取代苯基环己基化合物的新酯类、获得过程及其在制备具有镇痛特性的药物中的用途。与曲马多相比，这些通式（I）的新化合物具有更高的镇痛活性、更低的毒性和更长的有效期。
• New esters derived from substituted phenyl-cyclohexyl compounds
  申请人：VITA-INVEST, S.A.

  公开号：EP1219594A1

  公开（公告）日：2002-07-03

  New esters derived from substituted phenylcyclohexyl compounds, which are derived from Tramadol, process for obtaining them and their use for preparing a drug with analgesic properties. These new compounds of general formula (I) have a higher analgesic activity, a lower toxicity and a longer effective time period than Tramadol.

  由取代苯基环己基化合物衍生的新酯类，这些化合物是从曲马多衍生出来的，它们的获得过程以及它们在制备具有镇痛特性的药物中的用途。与曲马多相比，这些通式（I）的新化合物具有更高的镇痛活性、更低的毒性和更长的有效期。
• TAMPER-RESISTANT DOSAGE FORM WITH IMMEDIATE RELEASE AND RESISTANCE AGAINST SOLVENT EXTRACTION
  申请人：Grünenthal GmbH

  公开号：EP3698776A1

  公开（公告）日：2020-08-26

  The invention relates to a tamper-resistant pharmaceutical dosage form comprising a multitude of particles which comprise a pharmacologically active compound, preferably selected from opioids; a polyalkylene oxide having a weight average molecular weight within the range of from 200,000 g/mol to 2,000,000 g/mol, and a disintegrant; wherein the pharmacologically active compound is dispersed in a matrix comprising the polyalkylene oxide and the disintegrant; wherein the content of the disintegrant is more than 20 wt.-%, based on the total weight of the particles; wherein the content of the polyalkylene oxide is at least 25 wt.-%, based on the total weight of the particles; and wherein the dosage form provides under in vitro conditions immediate release of the pharmacologically active compound in accordance with Ph. Eur.

  本发明涉及一种防篡改药物剂型，其包括多种颗粒，这些颗粒包括药理活性化合物，优选选自阿片类药物；聚环氧烷，其重量平均分子量在200,000g/mol至2,000,000g/mol范围内；以及崩解剂；其中，药理活性化合物分散在由聚环氧烷和崩解剂组成的基质中；其中，基于颗粒的总重量，崩解剂的含量超过20重量％；其中，基于颗粒的总重量，聚环氧烷的含量至少为25重量％；以及其中，该剂型可在药理活性化合物和崩解剂的作用下立即崩解。其中，基于颗粒的总重量，崩解剂的含量超过 20 wt.-%；其中，基于颗粒的总重量，聚氧化亚烷烃的含量至少为 25 wt.-%；其中，根据 Ph. Eur.
• Abuse-proofed dosage form
  申请人：GRÜNENTHAL GMBH

  公开号：US10058548B2

  公开（公告）日：2018-08-28

  The invention relates to a dosage form that is thermoformed without discoloration and is safeguarded from abuse, comprising at least one synthetic or natural polymer having a breaking strength of at least 500 N in addition to one or more active substances that could be subject to abuse. The invention also relates to a corresponding method for producing said dosage form.

  本发明涉及一种热成型而不变色并可防止滥用的剂型，它包括至少一种断裂强度至少为 500 N 的合成或天然聚合物，以及一种或多种可能被滥用的活性物质。本发明还涉及生产上述剂型的相应方法。