2-azido-3,4,6-tri-O-benzyl-2-deoxy-D-glucopyranosyl-α(1->6)-3-O-methyl-D-chiro-inositol | 371788-98-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-azido-3,4,6-tri-O-benzyl-2-deoxy-D-glucopyranosyl-α(1->6)-3-O-methyl-D-chiro-inositol
• CAS: 371788-98-6
• 化学式: C₃₄H₄₁N₃O₁₀
• 分子量: 651.714
• InChiKey: IQDIBMKEGVXDPS-ZDLHDHHVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.64
• 重原子数：
  47.0
• 可旋转键数：
  14.0
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  185.06
• 氢给体数：
  4.0
• 氢受体数：
  11.0

反应信息

• 作为反应物：
  描述：

  2-azido-3,4,6-tri-O-benzyl-2-deoxy-D-glucopyranosyl-α(1->6)-3-O-methyl-D-chiro-inositol 在 palladium on activated charcoal 氢气 作用下， 以 甲醇 为溶剂， 反应 24.0h， 以100%的产率得到2-amino-2-deoxy-D-glucopyranosyl-α(1->6)-3-O-methyl-D-chiro-inositol
  参考文献：
  名称：

  Synthesis and Structure of 1-D-6-O-(2-Amino-2-deoxy-α- and -β-D-gluco- and -galactopyranosyl)-3-O-methyl-D-chiro-inositol

  摘要：

  A convenient preparative synthesis of 1-D-6-O-(2-amino-2-deoxy-alpha-D-glucopyranosyl)-3-O-methyl-chiro-inositol), 1-D-6-O-(2-amino-2-deoxy-beta-D-glucopyranosyl)-3-O-methyl- chiro-inositol (1b), I-D-6-O-(2-amino-2-deoxy-alpha-D-galactopyranosyl)-3-O-methyl-chiro-inositol (IIb), and 1-D-6-O-(2-amino-2-deoxy-beta-D-galactopyranosyl)-3-O-methyl-chiro-ino- sitol (IIb) from 3-O-methyl-D-chiro-inositol (pinitol) as starting material is reported. These compounds contain some of the basic structural motifs proposed for insulin mediators, The three-dimensional structures of these compounds have been determined by NMR spectroscopy and molecular dynamics simulations.

  DOI：

  10.1002/1099-0690(200203)2002:5<889::aid-ejoc889>3.0.co;2-3
• 作为产物：
  描述：

  D-松醇 在 三氟甲磺酸三甲基硅酯 、 4 A molecular sieve 、 D(+)-10-樟脑磺酸 、 水 、 对甲苯磺酸 、 三氟乙酸 、 原甲酸三甲酯 作用下， 以 甲醇 、 二氯甲烷 、 丙酮 为溶剂， 反应 49.67h， 生成 2-azido-3,4,6-tri-O-benzyl-2-deoxy-D-glucopyranosyl-α(1->6)-3-O-methyl-D-chiro-inositol
  参考文献：
  名称：

  Synthesis and Structure of 1-D-6-O-(2-Amino-2-deoxy-α- and -β-D-gluco- and -galactopyranosyl)-3-O-methyl-D-chiro-inositol

  摘要：

  A convenient preparative synthesis of 1-D-6-O-(2-amino-2-deoxy-alpha-D-glucopyranosyl)-3-O-methyl-chiro-inositol), 1-D-6-O-(2-amino-2-deoxy-beta-D-glucopyranosyl)-3-O-methyl- chiro-inositol (1b), I-D-6-O-(2-amino-2-deoxy-alpha-D-galactopyranosyl)-3-O-methyl-chiro-inositol (IIb), and 1-D-6-O-(2-amino-2-deoxy-beta-D-galactopyranosyl)-3-O-methyl-chiro-ino- sitol (IIb) from 3-O-methyl-D-chiro-inositol (pinitol) as starting material is reported. These compounds contain some of the basic structural motifs proposed for insulin mediators, The three-dimensional structures of these compounds have been determined by NMR spectroscopy and molecular dynamics simulations.

  DOI：

  10.1002/1099-0690(200203)2002:5<889::aid-ejoc889>3.0.co;2-3