| 129594-73-6

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• CAS: 129594-73-6
• 化学式: C₁₇H₂₂O₂
• 分子量: 258.36
• InChiKey: HHCDQEAKNPKDJR-WBOJAVRRSA-N

物化性质

• 沸点：
  377.5±15.0 °C(Predicted)
• 密度：
  1.116±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.36
• 重原子数：
  19.0
• 可旋转键数：
  2.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.59
• 拓扑面积：
  37.3
• 氢给体数：
  1.0
• 氢受体数：
  2.0

反应信息

• 作为产物：
  描述：

  (1R,3S,4R)-3-[(R)-hydroxy(phenyl)methyl]-1,7,7-trimethylbicyclo[2.2.1]heptan-2-one 在 lithium diisopropyl amide 作用下， 以 四氢呋喃 为溶剂， 反应 4.75h， 生成
  参考文献：
  名称：

  Hutchinson, J. H.; Li, D. L. F.; Money, T., Canadian Journal of Chemistry, 1991, vol. 69, # 3, p. 558 - 566

  摘要：

  DOI：

文献信息

• Synthesis and absolute configuration of the antiparasitic furanosesquiterpenes (-)-furodysin and (-)-furodysinin. Camphor as a six-membered ring chiral pool template
  作者：Valerie Vaillancourt、Mohamad R. Agharahimi、Uma N. Sundram、Olivier Richou、D. John Faulkner、Kim F. Albizati

  DOI：10.1021/jo00001a069

  日期：1991.1

  The syntheses of (-)-furodysin ((-)-2a) and (-)-furodysinin ((-)-3a) in four steps starting from (+)-9-bromocamphor (18) has been accomplished, thus establishing the absolute configuration of these and related metabolites. This was made possible by the unexpected exo selectivity in the aldol condensation of camphor-like enolates with aldehydes. This has been found to be a general phenomenon in the camphor system. Further, anionic fragmentation of the C1-C7 bond of camphor derivatives has allowed access to synthetic intermediates containing functionalized six-membered rings, thus opening up avenues from camphor to a new class of chiral pool elements not currently available from chiral pool substances.