1,2-bis(2-bromoacetate)-glycyrrhetinic acid methyl ester | 1243207-74-0

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: 1,2-bis(2-bromoacetate)-glycyrrhetinic acid methyl ester
• CAS: 1243207-74-0
• 化学式: C₃₅H₅₀Br₂O₇
• 分子量: 742.586
• InChiKey: NUIOFJDEBRSKLE-RNWZDZOISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.36
• 重原子数：
  44.0
• 可旋转键数：
  5.0
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  95.97
• 氢给体数：
  0.0
• 氢受体数：
  7.0

反应信息

• 作为反应物：
  描述：

  1,2-bis(2-bromoacetate)-glycyrrhetinic acid methyl ester 在 sodium azide 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 生成 1,2-bis(2-azidoacetate)-glycyrrhetinic acid methyl ester
  参考文献：
  名称：

  A New Dual-Responsive Organogel Based on Uracil-Appended Glycyrrhetinic Acid

  摘要：

  A novel functional tweezer based on uracil-appended glycyrrhetinic acid with excellent gelation ability was synthesized, and the gel could transform to sol by F(-) and Hg(2+).

  DOI：

  10.1021/ol201129y
• 作为产物：
  描述：

  methyl (2β,3α,18β)-2,3-dihydroxy-11-oxo-olean-12-en-30-oate 、 溴乙酰溴 在 potassium carbonate 作用下， 以 氯仿 为溶剂， 生成 1,2-bis(2-bromoacetate)-glycyrrhetinic acid methyl ester
  参考文献：
  名称：

  A New Dual-Responsive Organogel Based on Uracil-Appended Glycyrrhetinic Acid

  摘要：

  A novel functional tweezer based on uracil-appended glycyrrhetinic acid with excellent gelation ability was synthesized, and the gel could transform to sol by F(-) and Hg(2+).

  DOI：

  10.1021/ol201129y

文献信息

• Synthesis and binding ability of 1,2,3-triazole-based triterpenoid receptors for recognition of Hg2+ ion
  作者：Jun Hu、Meng Zhang、Li B. Yu、Yong Ju

  DOI：10.1016/j.bmcl.2010.06.079

  日期：2010.8

  A novel type of receptors based on 1,2,3-triazole glycyrrhetinic acid derived from natural triterpenoid molecules has been synthesized via click chemistry and they showed high selectivity and affinity for Hg2+ ion by both the 1,2,3-triazole rings and aldehyde groups. (C) 2010 Elsevier Ltd. All rights reserved.