dimethyl 3,4-seco-5α-cholestan-3,4-dioate | 1180-19-4

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: dimethyl 3,4-seco-5α-cholestan-3,4-dioate
• 英文别名: 3.4-seco-5α-cholestanedioic acid-(3.4)-dimethyl ester；3.4-Seco-5α-cholestandisaeure-(3.4)-dimethylester；3:4-Seco-3,4-dimethoxycarbonyl-5α-cholestan
• CAS: 1180-19-4
• 化学式: C₂₉H₅₀O₄
• 分子量: 462.714
• InChiKey: UXXWZUVYKCJQIA-YLFAAKNDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.05
• 重原子数：
  33.0
• 可旋转键数：
  9.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.93
• 拓扑面积：
  52.6
• 氢给体数：
  0.0
• 氢受体数：
  4.0

反应信息

• 作为反应物：
  描述：

  dimethyl 3,4-seco-5α-cholestan-3,4-dioate 在 sodium methylate 作用下， 以 甲醇 、 苯 为溶剂， 反应 50.0h， 生成 2α-carbomethoxy-A-nor-5α-cholestan-3β-ol
  参考文献：
  名称：

  A-类固醇。1.通过狄克曼缩合获得的2-羰基甲氧基-A-去甲胆甾烷-3-酮的立体化学。

  摘要：

  DOI：

  10.1016/0039-128x(82)90065-4
• 作为产物：
  描述：

  7-oxo-3,4-seco-cholestene-(5)-dioic acid-(3,4) 在 重氮甲烷 、 盐酸 、 amalgamated zinc 、 乙醚 、 溶剂黄146 作用下， 生成 dimethyl 3,4-seco-5α-cholestan-3,4-dioate
  参考文献：
  名称：

  Auditory Model Enhances Relative-Timing Learning

  摘要：

  In recent experiments (Q. Lai, C. H. Shea, & M. Little, 2000; C. H. Shea, G. Wulf, J. Park, & B. Gaunt, 2001), auditory models were found to be effective in enhancing relative-timing performance and learning in constant practice conditions. In the present experiment, the authors examined (a) whether an auditory model also enhances relative-timing learning in blocked and random practice conditions and (b) whether experience with the auditory model enhances participants' ability to produce the response by using different effector sequences. Participants (N = 48) were randomly assigned to 1 of 4 acquisition conditions in which an auditory model was or was not present and the practice schedule was blocked or random. In the acquisition phase, all participants alternately pressed 2 keys on a keyboard in an attempt to match 5 goal intervals. In the auditory model conditions, a sequence of tones was played before each acquisition trial. The tones represented the correct timing sequence for that trial. One retention and 3 effector-transfer tests without feedback were administered about 24 hr after the completion of acquisition. The results indicated that the auditory model enhanced relative-timing performance and learning independently of practice schedule. In addition, the auditory model enhanced relative timing on the effector-transfer tests, but absolute-timing performance and learning were not affected by the auditory model. Thus, relative timing was found to be effector independent but absolute timing was not.

  DOI：

  10.1080/00222890209601948

文献信息

• Characterization of Indoor Particle Sources Using Continuous Mass and Size Monitors
  作者：Christopher M. Long、Helen H. Suh、Petros Koutrakis

  DOI：10.1080/10473289.2000.10464154

  日期：2000.7

  A comprehensive indoor particle characterization study was conducted in nine Boston-area homes in 1998 in order to characterize sources of PM in indoor environments. State-of-the-art sampling methodologies were used to obtain continuous PM2.5 concentration and size distribution particulate data for both indoor and outdoor air. Study homes, five of which were sampled during two seasons, were monitored over week-long periods. Among other data collected during the extensive monitoring efforts were 24-hr elemental/organic carbon (EC/OC) particulate data as well as semi-continuous air exchange rates and time-activity information.This rich data set shows that indoor particle events tend to be brief, intermittent, and highly variable, thus requiring the use of continuous instrumentation for their characterization. In addition to dramatically increasing indoor PM2.5 concentrations, these data demonstrate that indoor particle events can significantly alter the size distribution and composition of indoor particles. Source event data demonstrate that the impacts of indoor activities are especially pronounced in the ultrafine (d(a) less than or equal to 0.1 mu m) and coarse (2.5 less than or equal to d(a) less than or equal to 10 mu m) modes. Among the sources of ultrafine particles characterized in this study are indoor ozone/terpene reactions. furthermore, EC/OC data suggest that organic carbon is a major constituent of particles emitted during indoor source events. Whether exposures to indoor-generated particles, particularly from large short-term peak events, may be associated with adverse health effects will become clearer when biological mechanisms are better known.
• 79. The action of selenium dioxide on sterols and bile acids. Part III. Cholesterol
  作者：O. Rosenheim、W. W. Starling

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• Über Gallensäuren und verwandte Stoffe. 17. Mitteilung. Bildung von Lactonen aus Ketonen mit Benzopersäure
  作者：V. Burckhardt、T. Reichstein

  DOI：10.1002/hlca.19420250704

  日期：1942.12.1
• 10. Steroids and related compounds. Part V. Steroid diosphenols
  作者：V. A. Petrow、W. W. Starling

  DOI：10.1039/jr9400000060

  日期：——
• Levisalles,J.; Tkatchenko,I., Bulletin de la Societe Chimique de France, 1966, p. 1287 - 1292
  作者：Levisalles,J.、Tkatchenko,I.

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  日期：——