(+/-)-Salvirecognine | 701208-48-2

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: (+/-)-Salvirecognine
• 英文别名: 8,8-dimethyl-2-propan-2-yl-7,8a,9,10-tetrahydro-6H-phenanthren-3-ol
• CAS: 701208-48-2
• 化学式: C₁₉H₂₆O
• 分子量: 270.415
• InChiKey: OXKJXQWUKRTLGT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.4
• 重原子数：
  20
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.58
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  (+/-)-Salvirecognine 在 palladium on activated charcoal 氢气 作用下， 以 乙醇 为溶剂， 反应 1.0h， 以90%的产率得到2-Isopropyl-8,8-dimethyl-4b,5,6,7,8,8a,9,10-octahydro-phenanthren-3-ol
  参考文献：
  名称：

  Norabietane diterpenoids and other terpenoids from salvia recognita

  摘要：

  Seven diterpenoids, three of them being new, salvirecognine, salvirecognine, 6 alpha-hydroxy-11,12-dioxo-8,13-abieta-diene, were isolated from the roots of Salvia recognita together with three known triterpenoids. The structures of the known compounds were established by comparing their spectral data to those of authentic samples as well as by TLC comparisons. The structures of the new compounds were deduced by 1D and 2D NMR techniques including APT, DEFT, COSY and HETCOR. (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0031-9422(97)01056-x
• 作为产物：
  描述：

  7-Isopropyl-6-methoxy-1,1-dimethyl-1,9,10,10a-tetrahydro-2H-phenanthren-3-one 在 dichloroaluminum hydride 、 三溴化硼 作用下， 以 乙醚 、 二氯甲烷 为溶剂， 生成 (+/-)-Salvirecognine
  参考文献：
  名称：

  一种合成三环二萜的新方法

  摘要：

  已经发现了一种新颖的方法，并且通过使用它完成了第一个（±）-Salvirecognine的全合成。其中分子内环化和Friedel-Crafts烷基化同时发生，从而提供了合成芳族三环二萜的关键中间体。

  DOI：

  10.1016/j.tetlet.2004.02.136

文献信息

• A novel approach to synthesis of tricyclic diterpenoid
  作者：Xuanjia Peng、Xuegong She、Ying Su、Tongxin Wu、Xinfu Pan

  DOI：10.1016/j.tetlet.2004.02.136

  日期：2004.4

  A novel approach has been found and the first total synthesis of (±)-Salvirecognine was accomplished by using it. In which intramolecular cyclization and Friedel–Crafts alkylation took place simultaneously to afford key intermediates for synthesis of aromatic tricyclic diterpenoids.

  已经发现了一种新颖的方法，并且通过使用它完成了第一个（±）-Salvirecognine的全合成。其中分子内环化和Friedel-Crafts烷基化同时发生，从而提供了合成芳族三环二萜的关键中间体。
• Norabietane diterpenoids and other terpenoids from salvia recognita
  作者：Nur Tan、Gülaçti Topçu、Ayhan Ulubelen

  DOI：10.1016/s0031-9422(97)01056-x

  日期：1998.9

  Seven diterpenoids, three of them being new, salvirecognine, salvirecognine, 6 alpha-hydroxy-11,12-dioxo-8,13-abieta-diene, were isolated from the roots of Salvia recognita together with three known triterpenoids. The structures of the known compounds were established by comparing their spectral data to those of authentic samples as well as by TLC comparisons. The structures of the new compounds were deduced by 1D and 2D NMR techniques including APT, DEFT, COSY and HETCOR. (C) 1998 Elsevier Science Ltd. All rights reserved.