Breviscapine | 116122-36-2

• 物质功能分类: 生物化工 - 生化试剂 - 激动剂抑制剂
• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 黄酮类化合物
• 英文名称: Breviscapine
• 英文别名: 6-[5,6-dihydroxy-2-(4-hydroxyphenyl)-4-oxochromen-7-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid
• CAS: 116122-36-2
• 化学式: C₂₁H₁₈O₁₂
• 分子量: 462.4
• InChiKey: DJSISFGPUUYILV-UHFFFAOYSA-N

物化性质

• LogP：
  0.426 (est)

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  33
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  203
• 氢给体数：
  7
• 氢受体数：
  12

制备方法与用途

用途：活血化淤，通络止痛。适用于偏瘫、脑梗塞、脑栓塞、中风后遗症、冠心病、心绞痛、缺血性心脏病、老年痴呆、高粘滞血症及眩晕症等。

文献信息

• METHOD FOR PREPARING 5,6,4'-TRIHYDROXYFLAVONE-7-0-D-GLUCURONIC ACID
  申请人：KPC Pharmaceuticals, Inc.

  公开号：EP2840088B1

  公开（公告）日：2017-02-01
• A CLINICAL PREPARATION OF SCUTELLARIN AND THE PREPARATION METHOD THEREOF
  申请人：KPC Pharmaceuticals, Inc.

  公开号：EP2612671B1

  公开（公告）日：2019-10-09
• SCUTELLARIN AMIDE DERIVATIVES, AND PREPARATION METHODS AND USES THEREOF
  申请人：HEILONGJIANG BAYI AGRICULTURAL UNIVERSITY

  公开号：US20220002332A1

  公开（公告）日：2022-01-06

  The present disclosure discloses scutellarin amide derivatives and preparation methods and uses thereof, which belongs to the field of natural drugs and medicinal chemistry. The scutellarin amide derivatives according to the present disclosure and pharmaceutically acceptable salts thereof have a structure as shown in the following general formula I: scutellarin derivatives, which are prepared by amidation at the glycosylcarboxyl site, can be used in the manufacture of anti-tumor drugs, which have a good effect against tumor cell proliferation.