1-[3-Methoxy-4-[3-(4-methylpiperazin-1-yl)propoxy]phenyl]ethanone | 704870-86-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-[3-Methoxy-4-[3-(4-methylpiperazin-1-yl)propoxy]phenyl]ethanone
• CAS: 704870-86-0
• 化学式: C₁₇H₂₆N₂O₃
• 分子量: 306.405
• InChiKey: CHBZBVCSMYJUPU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  22
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.59
• 拓扑面积：
  42
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  1-[3-Methoxy-4-[3-(4-methylpiperazin-1-yl)propoxy]phenyl]ethanone 在 盐酸 、 硝酸 、 铁粉 、 溶剂黄146 作用下， 以 乙醇 、 水 为溶剂， 反应 2.0h， 生成
  参考文献：
  名称：

  Synthesis of condensed quinolines and quinazolines as DNA ligands

  摘要：

  Among new condensed quinolines and quinazolines the design of which were inspired by anti-cancer DNA-binding alkaloids such as camptothecin and batracyclin, DNA binding tests identify the 8-methoxy-7-piperazinylpropoxyindeno[1,2-b]quinolin-II-one tetracyclic system as a new motif for DNA recognition. (C) 2003 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2003.10.014
• 作为产物：
  描述：

  香草乙酮 、 1-(3-chloropropyl)-4-methylpiperazine dihydrochloride 在 potassium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 生成 1-[3-Methoxy-4-[3-(4-methylpiperazin-1-yl)propoxy]phenyl]ethanone
  参考文献：
  名称：

  Synthesis of condensed quinolines and quinazolines as DNA ligands

  摘要：

  Among new condensed quinolines and quinazolines the design of which were inspired by anti-cancer DNA-binding alkaloids such as camptothecin and batracyclin, DNA binding tests identify the 8-methoxy-7-piperazinylpropoxyindeno[1,2-b]quinolin-II-one tetracyclic system as a new motif for DNA recognition. (C) 2003 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2003.10.014

文献信息

• Synthesis of condensed quinolines and quinazolines as DNA ligands
  作者：Natacha Malecki、Pascal Carato、Benoı̂t Rigo、Jean-François Goossens、Raymond Houssin、Christian Bailly、Jean-Pierre Hénichart

  DOI：10.1016/j.bmc.2003.10.014

  日期：2004.2

  Among new condensed quinolines and quinazolines the design of which were inspired by anti-cancer DNA-binding alkaloids such as camptothecin and batracyclin, DNA binding tests identify the 8-methoxy-7-piperazinylpropoxyindeno[1,2-b]quinolin-II-one tetracyclic system as a new motif for DNA recognition. (C) 2003 Elsevier Ltd. All rights reserved.