(+/-)-Kikemanin | 32886-80-9

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 原小檗碱生物碱及其衍生物
• 英文名称: (+/-)-Kikemanin
• 英文别名: Kikemanin；2,3,9-trimethoxy-6,8,13,13a-tetrahydro-5H-isoquinolino[2,1-b]isoquinolin-10-ol
• CAS: 32886-80-9
• 化学式: C₂₀H₂₃NO₄
• 分子量: 341.407
• InChiKey: DIHXHTWYVOYYDC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  25
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  51.2
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• A MEDICINE FOR ABSTAINING FROM ADDICTION TO DRUGS AND PROCESS THEREOF
  申请人：Shanxi Yabao Pharmaceutical Group Corp.

  公开号：EP1911456B1

  公开（公告）日：2012-12-26
• Medicine to Treat Drug Addiction and Preparation Method Thereof
  申请人：Yang Zheng

  公开号：US20090123559A1

  公开（公告）日：2009-05-14

  The present invention declares a pharmaceutical extract, composition that has effect to treat drug addiction, and its preparation method and quality control method. This extract is extracted from Radix Stephaniae Epigaeae. Starting medicine material of said composition is Radix Ginseng, Radix Astragali, Rhizoma Corydalis, Radix Angelicae Sinensis and Radix Ophiopogonis; and said composition also can prepared by ethanol extract of Radix Ginseng, ethanol extract of Radix Angelicae Sinensis, total alkaloids of Radix Stephaniae Epigaeae, water extract of Radix Astragali and water extract of Radix Ophiopogonis. Quality control method of said pharmaceutical composition includes one of or several of identifications and content determinations. The present invention also declares the use of said pharmaceutical extract, composition in the preparation of a medicine to treat drug addiction.
• MEDICINE TO TREAT DRUG ADDICTION AND PREPARATION METHOD THEREOF
  申请人：YANG Zheng

  公开号：US20110111074A1

  公开（公告）日：2011-05-12

  The present invention declares a pharmaceutical extract, composition that has effect to treat drug addiction, and its preparation method and quality control method. This extract is extracted from Radix Stephaniae Epigaeae. Starting medicine material of said composition is Radix Ginseng, Radix Astragali, Rhizoma Corydalis, Radix Angelicae Sinensis and Radix Ophiopogonis; and said composition also can prepared by ethanol extract of Radix Ginseng, ethanol extract of Radix Angelicae Sinensis, total alkaloids of Radix Stephaniae Epigaeae, water extract of Radix Astragali and water extract of Radix Ophiopogonis. Quality control method of said pharmaceutical composition includes one of or several of identifications and content determinations. The present invention also declares the use of said pharmaceutical extract, composition in the preparation of a medicine to treat drug addiction.
• US8361524B2
  申请人：——

  公开号：US8361524B2

  公开（公告）日：2013-01-29
• [EN] CRYSTALLINE SALTS OF CORYDALMINE<br/>[FR] SELS CRISTALLINS DE CORYDALMINE
  申请人：YANG ZHENG

  公开号：WO2020107335A1

  公开（公告）日：2020-06-04

  The present disclosure relates to crystalline salt forms of the following Compound (1), also known as l-corydalmine or l-CDL, and methods for the preparation thereof, pharmaceutical compositions thereof, and their use in methods for the treatment of chronic pain, anxiety, insomnia, hyperlipidemia, hypercholesterolemia, hypertriglyceridemia, hepatic steatosis, and metabolic syndrome, et al. (I)