Isoguanosine | 1818-71-9

• 物质功能分类: 生物化工 - 提取物
• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘌呤核苷
• 英文名称: Isoguanosine
• 英文别名: 6-amino-9-[3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1H-purin-2-one
• CAS: 1818-71-9
• 化学式: C₁₀H₁₃N₅O₅
• 分子量: 283.24
• InChiKey: MIKUYHXYGGJMLM-UHFFFAOYSA-N

物化性质

• 溶解度：
  溶于氯仿、二氯甲烷、乙酸乙酯、DMSO、丙酮等。
• 密度：
  2.25±0.1 g/cm3(Predicted)
• 熔点：
  237-241 °C(Solv: water (7732-18-5))

计算性质

• 辛醇/水分配系数(LogP)：
  -3
• 重原子数：
  20
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  153
• 氢给体数：
  5
• 氢受体数：
  7

安全信息

• WGK Germany：
  3
• 海关编码：
  2934999090
• 危险性防范说明：
  P261,P305+P351+P338
• 危险性描述：
  H302,H315,H319
• 储存条件：
  -20°C，密封保存于干燥处。

制备方法与用途

异鸟苷简介

异鸟苷又名巴豆苷、2-羟基腺苷，是一种以生物碱为苷元的核糖苷。巴豆属大戟科植物，其果实及根叶均可入药。巴豆树是一种常绿乔木，高6~10米。在中医药中，异鸟苷主要来源于巴豆果实，具有温热、辛味的特点，功能破积、逐水、涌吐痰涎，主要用于治疗寒结便秘、腹水肿胀等症状，以及胸腹胀满急痛、大便不通等病症，并且在治疗泄泻痢疾、水肿腹大、痰饮喘满、喉风喉痹、痈疽及恶疮疥癣方面也有一定作用。需要注意的是异鸟苷有一定的毒性，使用时应谨慎。

异鸟苷主要产自浙江南部、福建、江西、湖南、广东、海南、广西、贵州、四川和云南等地。

应用

目前已有研究报道，异鸟苷具有抑制S-180腹水癌细胞和埃利希氏瘤细胞生长的作用。此外，异鸟苷对白血病细胞有非常强的抑制作用，并且在体内表现出良好的抑制效果，在临床应用中显示出较大潜力。

制备

目前国内外常用的异鸟苷提取、纯化方法包括回流提取法、超临界流体萃取法和聚酰胺柱层析法等。

化学性质

异鸟苷为白色结晶，可溶于甲醇、乙醇及DMSO等有机溶剂。其主要来源于巴豆（Croton tiglium L.）的果实。

用途

作为一种天然的鸟苷活性异构体，异鸟苷存在于巴豆种子中，并用于中药。实验表明，与腺苷相比，在降低兔子和猫的血压方面，它表现出更高的活性。

文献信息

• MODIFIED RNA AGENTS WITH REDUCED OFF-TARGET EFFECT
  申请人：Alnylam Pharmaceuticals, Inc.

  公开号：US20210238595A1

  公开（公告）日：2021-08-05

  One aspect of the present invention relates to double-stranded RNA (dsRNA) agent capable of inhibiting the expression of a target gene. The antisense strand of the dsRNA molecule comprises at least one thermally destabilizing nucleotide occurring at a seed region; the dsRNA comprises at least four 2′-fluoro modifications, and the sense strand of the dsRNA molecule comprises ligand, wherein the ligand is an ASGPR ligand. Other aspects of the invention relate to pharmaceutical compositions comprising these dsRNA molecules suitable for therapeutic use, and methods of inhibiting the expression of a target gene by administering these dsRNA molecules, e.g., for the treatment of various disease conditions.
• BIFUNCTIONAL NUCLEOSIDE HYDROGEL, PREPARATION METHOD THEREFOR AND USE THEREOF
  申请人：SICHUAN UNIVERSITY

  公开号：US20220218605A1

  公开（公告）日：2022-07-14

  A bifunctional nucleoside hydrogel is formed by dissolving isoguanosine, guanosine and a borate in water or an aqueous solution and then crosslinking same. The bifunctional nucleoside hydrogel integrates a carrier and a drug effect and has a significant inhibitory effect on the activity of tumor cells, and in particular has a significant inhibitory effect on the activity of cells related to lung cancer, glioma, osteoma, colon cancer, breast cancer, oral squamous cell carcinoma and tongue squamous cell carcinoma, of which the inhibitory effect on the activity of cells related to oral squamous cell carcinoma is the best. Therefore, the bifunctional nucleoside hydrogel has potential application prospects in preparing anti-tumor drugs, and particularly, same can provide a new approach for treating oral squamous cell carcinoma.
• Modified RNA Agents with Reduced Off-Target Effect
  申请人：ALNYLAM PHARMACEUTICALS, INC.

  公开号：US20220290145A1

  公开（公告）日：2022-09-15

  One aspect of the present invention relates to double-stranded RNA (dsRNA) agent capable of inhibiting the expression of a target gene. The antisense strand of the dsRNA molecule comprises at least one thermally destabilizing nucleotide occurring at a seed region; the dsRNA comprises at least four 2′-fluoro modifications, and the sense strand of the dsRNA molecule comprises ligand, wherein the ligand is an ASGPR ligand. Other aspects of the invention relate to pharmaceutical compositions comprising these dsRNA molecules suitable for therapeutic use, and methods of inhibiting the expression of a target gene by administering these dsRNA molecules, e.g., for the treatment of various disease conditions.
• [EN] COMPOUNDS, COMPOSITIONS AND METHODS FOR MODULATING FAT METABOLISM<br/>[FR] COMPOSES, COMPOSITIONS ET METHODES PERMETTANT DE MODULER LE METABOLISME DES GRAISSES
  申请人：OBETHERAPY BIOTECHNOLOGY

  公开号：WO2004037159A2

  公开（公告）日：2004-05-06

  Methods, compositions and methods of identifying candidate compounds, for modulating fat metabolism and/or inhibiting Apobec-1 activity are provided.