22-(4-Amino-3,5-dihydroxy-6-methyloxan-2-yl)oxy-1,3,26-trihydroxy-12-methyl-10-oxo-6,11,28-trioxatricyclo[22.3.1.05,7]octacosa-8,14,16,18,20-pentaene-25-carboxylic acid | 7681-93-8

• 物质功能分类: 原料药 - 抗生素类药物 - 其它抗生素类药
• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 22-(4-Amino-3,5-dihydroxy-6-methyloxan-2-yl)oxy-1,3,26-trihydroxy-12-methyl-10-oxo-6,11,28-trioxatricyclo[22.3.1.05,7]octacosa-8,14,16,18,20-pentaene-25-carboxylic acid
• CAS: 7681-93-8
• 化学式: C₃₃H₄₇NO₁₃
• 分子量: 665.7
• InChiKey: NCXMLFZGDNKEPB-UHFFFAOYSA-N

物化性质

• 熔点：
  2000C (dec)
• 比旋光度：
  D20 +278° (c = 1 in CH3COOH)
• 沸点：
  952℃
• 密度：
  1.0 g/mL at 20 °C(lit.)
• 闪点：
  >110°(230°F)
• 溶解度：
  溶于二甲基亚砜
• LogP：
  0.880 (est)
• 物理描述：
  White to creamy-white crystalline powder
• 旋光度：
  [α]D/20 + 250° to + 295° (a 1 % w/v solution in glacial acetic acid, at 20 °C and calculated with reference to the dried material)

计算性质

• 辛醇/水分配系数(LogP)：
  -1.3
• 重原子数：
  47
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.64
• 拓扑面积：
  231
• 氢给体数：
  7
• 氢受体数：
  14

安全信息

• 危险品标志：
  Xn
• 安全说明：
  S24/25
• 危险类别码：
  R22
• WGK Germany：
  2
• 海关编码：
  29419090
• 危险品运输编号：
  NONH for all modes of transport
• RTECS号：
  TK3325000
• 储存条件：
  2-8℃

SDS

Name:	Pimafucin (pimaricin in a 2.5% sterile water suspension) Material Safety Data Sheet
Synonym:	Pimaricin; Devolan; Myprozine; Natacyn; Tennecefin; Natamycin
CAS:	7681-93-8

Section 1 - Chemical Product MSDS Name:Pimafucin (pimaricin in a 2.5% sterile water suspension) Material Safety Data Sheet
Synonym:Pimaricin; Devolan; Myprozine; Natacyn; Tennecefin; Natamycin

---

Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS

CAS#	Chemical Name	content	EINECS#
7681-93-8	Pimaricin	ca.98.0	231-683-5

Hazard Symbols: None Listed.
Risk Phrases: None Listed.

---

Section 3 - HAZARDS IDENTIFICATION
EMERGENCY OVERVIEW
Light sensitive.
Potential Health Effects
Eye:
May cause eye irritation.
Skin:
May cause skin irritation.
Ingestion:
May cause irritation of the digestive tract.
Inhalation:
May cause respiratory tract irritation.
Chronic:
No information found.

---

Section 4 - FIRST AID MEASURES
Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.
Skin:
Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Remove contaminated clothing and shoes.
Ingestion:
If victim is conscious and alert, give 2-4 cupfuls of milk or water.
Never give anything by mouth to an unconscious person. Get medical aid immediately.
Inhalation:
Get medical aid immediately. Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen.
Notes to Physician:
Treat symptomatically and supportively.
Antidote: None reported.

---

Section 5 - FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Substance is noncombustible.
Extinguishing Media:
Use agent most appropriate to extinguish fire.

---

Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Clean up spills immediately, observing precautions in the Protective Equipment section. Sweep up or absorb material, then place into a suitable clean, dry, closed container for disposal. Avoid generating dusty conditions. Provide ventilation.

---

Section 7 - HANDLING and STORAGE
Handling:
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Minimize dust generation and accumulation. Avoid contact with eyes, skin, and clothing. Keep container tightly closed.
Avoid ingestion and inhalation. Use with adequate ventilation.
Storage:
Keep container closed when not in use. Store in a cool, dry, well-ventilated area away from incompatible substances. Keep refrigerated. (Store below 4C/39F.) Keep containers tightly closed.

---

Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Use process enclosure, local exhaust ventilation, or other engineering controls to control airborne levels.
Exposure Limits CAS# 7681-93-8: CAS# 7732-18-5: Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.

---

Section 9 - PHYSICAL AND CHEMICAL PROPERTIES

Physical State: Solid
Color: Not available.
Odor: Not available.
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: @ 760.00mm Hg
Freezing/Melting Point: 200 deg C
Autoignition Temperature: Not available.
Flash Point: Not available.
Explosion Limits, lower: N/A
Explosion Limits, upper: N/A
Decomposition Temperature:
Solubility in water: ketones, cyclohexanols
Specific Gravity/Density: 1.01
Molecular Formula: C33H47NO13
Molecular Weight: 665.72

---

Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Stable under normal temperatures and pressures.
Conditions to Avoid:
Incompatible materials, light, dust generation, strong oxidants.
Incompatibilities with Other Materials:
Strong oxidizing agents.
Hazardous Decomposition Products:
Carbon monoxide, oxides of nitrogen, irritating and toxic fumes and gases, carbon dioxide.
Hazardous Polymerization: Has not been reported

---

Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 7681-93-8: TK3325000 CAS# 7732-18-5: ZC0110000 LD50/LC50:
CAS# 7681-93-8: Oral, mouse: LD50 = 1500 mg/kg; Oral, rabbit: LD50 = 1420 mg/kg; Oral, rat: LD50 = 2730 mg/kg.
CAS# 7732-18-5: Oral, rat: LD50 = >90 mL/kg.
Carcinogenicity:
Pimaricin - Not listed by ACGIH, IARC, or NTP.
Water - Not listed by ACGIH, IARC, or NTP.
Other:
See actual entry in RTECS for complete information.

---

Section 12 - ECOLOGICAL INFORMATION
Other No information available.

---

Section 13 - DISPOSAL CONSIDERATIONS
Dispose of in a manner consistent with federal, state, and local regulations.

---

Section 14 - TRANSPORT INFORMATION

IATA
Not regulated as a hazardous material.
IMO
Not regulated as a hazardous material.
RID/ADR
Not regulated as a hazardous material.

---

Section 15 - REGULATORY INFORMATION

European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: Not available.
Risk Phrases:
Safety Phrases:
S 24/25 Avoid contact with skin and eyes.
WGK (Water Danger/Protection)
CAS# 7681-93-8: No information available.
CAS# 7732-18-5: No information available.
Canada
CAS# 7732-18-5 is listed on Canada's DSL List.
CAS# 7681-93-8 is not listed on Canada's Ingredient Disclosure List.
CAS# 7732-18-5 is not listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 7681-93-8 is not listed on the TSCA inventory.
It is for research and development use only.
CAS# 7732-18-5 is listed on the TSCA inventory.

---

SECTION 16 - ADDITIONAL INFORMATION
N/A

制备方法与用途

纳他霉素是一种广泛应用于食品工业的天然抗真菌剂。下面是关于纳他霉素的一些关键信息：

生产与化学性质

• 生产方法：由游链霉菌（Streptomyces natalensis）受控发酵制得。
• 外观和物理特性：近白色到奶油黄色粉末，几乎无臭无味。可含有3mol的水。熔点280℃(分解)。几不溶于水，微溶于甲醇，溶于冰醋酸和二甲基亚砜。

主要用途

• 防霉剂：用于霉菌容易增殖的、暴露于空气中的食品表面时，有良好的抗霉效果。
• 发酵干酪：在发酵过程中可以抑制霉菌繁殖而让细菌正常生长与代谢。
• 其他应用：还可以应用于果蔬汁、蛋黄酱、沙拉酱等食品中。

最大允许使用量及残留标准

根据中国食品安全国家标准，纳他霉素在不同食品中的最大允许使用量和残留标准如下：

• 发酵酒：0.01g/L
• 蛋黄酱、沙拉酱：0.02g/kg，且残留量≤10mg/kg
• 果蔬汁（浆）：0.3g/kg，表面使用，混悬液喷雾或浸泡，残留量小于10mg/kg
• 发酵肉制品类、肉灌肠类、西式火腿（熏烤、烟熏、蒸煮火腿）、油炸肉类、熏、烤、烧肉类、酱卤肉制品类、糕点：均允许使用，最大使用量为0.3g/kg，表面使用，混悬液喷雾或浸泡，残留量小于10mg/kg
• 干酪：同发酵干酪

安全性

• 纳他霉素是一种天然产物，并且其安全性已经过多个权威机构认证。在正常使用下不会对人体健康造成危害。

使用注意事项

• 产品应贮存于密封良好、无直射阳光、＜15℃条件下。
• 在食品加工过程中需严格按照规定的使用量进行添加，以确保食品安全和品质。

总之，纳他霉素是一种有效且安全的防腐剂，在多种食品中有着广泛的应用前景。