rhodotorulic acid | 18928-00-2

• 物质功能分类: 有机原料 - 羧酸类化合物及衍生物 - 无环羧酸
• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: rhodotorulic acid
• 英文别名: N,N'-dihydroxy-N,N'-[3,3'-(3,6-dioxo-piperazine-2,5-diyl)-dipropyl]-bis-acetamide；Rhodotorulsaeure；Acetamide, N,N'-[[(2S,5S)-3,6-dioxo-2,5-piperazinediyl]di-3,1-propanediyl]bis[N-hydroxy-；N-[3-[5-[3-[acetyl(hydroxy)amino]propyl]-3,6-dioxopiperazin-2-yl]propyl]-N-hydroxyacetamide
• CAS: 18928-00-2；39108-08-2
• 化学式: C₁₄H₂₄N₄O₆
• 分子量: 344.368
• InChiKey: PUWVNTVQJFSBDH-UHFFFAOYSA-N

物化性质

• 密度：
  1.277±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -1.8
• 重原子数：
  24
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  139
• 氢给体数：
  4
• 氢受体数：
  6

安全信息

• RTECS号：
  AB8132530

制备方法与用途

红酵母酸可以有效防治果品采后病害，应用于多种场景。

反应信息

• 作为反应物：
  描述：

  rhodotorulic acid 在 methanol 作用下， 以 甲醇 为溶剂， 生成
  参考文献：
  名称：

  Fisher, Diane C.; Barclay-Peet, Susan J.; Balfe, Carol A., Inorganic Chemistry, 1989, vol. 28, # 24, p. 4399 - 4406

  摘要：

  DOI：

文献信息

• TARGETED IONOPHORE-BASED METAL DELIVERY
  申请人：The Regents of the University of California

  公开号：US20200113937A1

  公开（公告）日：2020-04-16

  The present disclosure provides ionophore compounds, which are useful for facilitating delivery of a metal ion to a cell, tissue or organ of interest. The present disclosure provides compositions comprising the subject ionophore compounds. The present disclosure provides methods of delivering a metal ion intracellularly to a target cell. The present disclosure also provides methods of treating a condition associated with a metal deficiency in an individual.

  本公开提供离子载体化合物，用于促进金属离子传递至感兴趣的细胞、组织或器官。本公开提供包含所述离子载体化合物的组合物。本公开提供将金属离子胞内传递至靶细胞的方法。本公开还提供治疗个体金属缺乏相关病症的方法。
• [EN] OXAZOUDINONES AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR TREATING BACTERIAL INFECTIONS, INCLUDING INFECTION OF MYCOBACTERIUM TUBERCULOSIS<br/>[FR] OXAZOUDINONES ET COMPOSITIONS PHARMACEUTIQUES ASSOCIÉES POUR LE TRAITEMENT D'INFECTIONS BACTÉRIENNES, Y COMPRIS DE L'INFECTION DE MYCOBACTERIUM TUBERCULOSIS
  申请人：UNIV OF ST THOMAS

  公开号：WO2018157043A1

  公开（公告）日：2018-08-30

  Disclosed are oxazolidinone compounds of Formula I: (I) salts thereof, antibacterial pharmaceutical compositions containing them, and use of the compounds to inhibit bacterial growth in mammals, including humans.

  揭示了式I的噁唑烷酮化合物：（I）其盐，含有它们的抗菌药物组合物，以及利用这些化合物抑制哺乳动物（包括人类）中细菌生长的用途。
• [EN] CYCLIC PEROXIDES AS PRODRUGS FOR SELECTIVE DELIVERY OF AGENTS<br/>[FR] PEROXYDES CYCLIQUES UTILISÉS EN TANT QUE PROMÉDICAMENTS POUR L'ADMINISTRATION SÉLECTIVE D'AGENTS
  申请人：UNIV CALIFORNIA

  公开号：WO2015123595A1

  公开（公告）日：2015-08-20

  Disclosed herein, inter alia, are prodrug compositions and methods of using the same for treatment and detection of disease. Specifically, disclosed herein is a compound of formula (I) having spiro-fused 1,2,4-trioxolane and piperidine rings, namely, 1,2,4-trioxa- 8-azaspiro[4.5] decane. Also disclosed is a pharmaceutical composition containing the compound and a phannaceutically acceptable carrier.

  本文披露了前药组合物及其用于治疗和检测疾病的方法。具体地，本文披露了一种具有螺合1,2,4-三噁烷和哌啶环的化合物的公式(I)，即1,2,4-三氧杂-8-氮杂螺[4.5]癸烷。还披露了含有该化合物和药用载体的药物组合物。
• STIMULI RESPONSIVE COMPOSITIONS FOR IRON CHELATION
  申请人：Xiong May Pang

  公开号：US20160184344A1

  公开（公告）日：2016-06-30

  The present technology provides new compositions comprising at least one cross-linked co-polymer. In some embodiments, the polyacrylamide co-polymer comprises water soluble subunits, cross-linking subunits, and iron chelating subunits. In other embodiments, the co-polymer comprises water soluble units, cross-linking subunits, and substituted subunits, which can be conjugated with iron-chelating agents. When these new particles are exposed to certain environments, such the presence of strong acids or oxidation agents, these particles are capable of breaking up so that the iron chelating agents can chelate iron or other metals from their environments. Methods to prepare these new compositions are also provided. These compositions or compositions comprising nanogels of the present technology may be used to treat metal overload conditions such as iron overload resulting from chronic transfusions.

  目前的技术提供了包含至少一种交联共聚物的新组合物。在某些实施例中，聚丙烯酰胺共聚物包括水溶性亚基、交联亚基和铁螯合亚基。在其他实施例中，共聚物包括水溶性单元、交联亚基和取代亚基，这些亚基可以与螯合铁的试剂结合。当这些新颗粒暴露在某些环境中，如强酸或氧化剂的存在时，这些颗粒能够分解，以便铁螯合试剂可以从它们的环境中螯合铁或其他金属。还提供了制备这些新组合物的方法。这些组合物或包含本技术的纳米凝胶的组合物可用于治疗金属过载症状，例如由于慢性输血导致的铁过载。
• [EN] NGAL-BINDING SIDEROPHORES AND USE THEREOF TO TREAT IRON DEFICIENCY AND IRON OVERLOAD<br/>[FR] SIDÉROPHORES SE LIANT À NGAL ET UTILISATION DE CEUX-CI POUR TRAITER UNE CARENCE EN FER ET UNE SURCHARGE EN FER
  申请人：UNIV COLUMBIA

  公开号：WO2010033847A1

  公开（公告）日：2010-03-25

  The invention provides compositions comprising a lipocalin, such as NGAL, and a mammalian siderophore that are useful as iron chelators and iron donors. The invention also provides mammalian siderophore compounds of Formula (I): The invention further provides, methods of treatment and methods of diagnosis.

  本发明提供了包含脂联素（如NGAL）和哺乳动物铁载体的组合物，这些组合物可用作铁螯合剂和铁供体。本发明还提供了公式（I）的哺乳动物铁载体化合物。此外，本发明还提供了治疗方法和诊断方法。