8-cyanodihydropalmatine

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 原小檗碱生物碱及其衍生物
• 英文名称: 8-cyanodihydropalmatine
• 英文别名: 2,3,9,10-tetramethoxy-6,8-dihydro-5H-isoquinolino[2,1-b]isoquinoline-8-carbonitrile
• 化学式: C₂₂H₂₂N₂O₄
• 分子量: 378.428
• InChiKey: RXUHTKZJTZPOFK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  28
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  64
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  sodium cyanide 、 7,8-dihydro-8-hydroxypalmatine 以 甲醇 、 水 为溶剂， 以84%的产率得到8-cyanodihydropalmatine
  参考文献：
  名称：

  In vitroinhibitory effects of palmatine fromEnantia chloranthaonTrypanosoma cruziandLeishmania infantum

  摘要：

  In an attempt to establish the components responsible for the use of Enantia chlorantha against cutaneous leishmaniasis in local traditional medicine, a well-known palmatine has been isolated in substantial amounts from a methanolic bark extract of this plant species. Palmatine therein obtained exhibited a significant inhibitory activity on growth of both Trypanosoma cruzi (IC50 0.068 mu M) and Leishmania infantum (IC50 0.79 mu M).

  DOI：

  10.1080/14786410902726241

文献信息

• Nyasse, Barthelemy; Nkwengoua; Sondengam, Pharmazie, 2002, vol. 57, # 6, p. 358 - 361
  作者：Nyasse, Barthelemy、Nkwengoua、Sondengam、Denier、Willson

  DOI：——

  日期：——
• <i>In vitro</i>inhibitory effects of palmatine from<i>Enantia chlorantha</i>on<i>Trypanosoma cruzi</i>and<i>Leishmania infantum</i>
  作者：Ernestine Tchouboun Nkwengoua、Igor Ngantchou、Barthélemy Nyasse、Colette Denier、Casimir Blonski、Bernd Schneider

  DOI：10.1080/14786410902726241

  日期：2009.8.15

  In an attempt to establish the components responsible for the use of Enantia chlorantha against cutaneous leishmaniasis in local traditional medicine, a well-known palmatine has been isolated in substantial amounts from a methanolic bark extract of this plant species. Palmatine therein obtained exhibited a significant inhibitory activity on growth of both Trypanosoma cruzi (IC50 0.068 mu M) and Leishmania infantum (IC50 0.79 mu M).