Streptomycin | 32448-21-8

• 物质功能分类: 原料药 - 抗生素类药物 - 氨基糖苷类药
• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: Streptomycin
• 英文别名: MMV688994；Strept-omycin；2-[3-(diaminomethylideneamino)-4-[3-[4,5-dihydroxy-6-(hydroxymethyl)-3-(methylamino)oxan-2-yl]oxy-4-formyl-4-hydroxy-5-methyloxolan-2-yl]oxy-2,5,6-trihydroxycyclohexyl]guanidine
• CAS: 32448-21-8
• 化学式: C₂₁H₃₉N₇O₁₂
• 分子量: 581.58
• InChiKey: UCSJYZPVAKXKNQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -8
• 重原子数：
  40
• 可旋转键数：
  9
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  336
• 氢给体数：
  12
• 氢受体数：
  15

文献信息

• NEW MODALITIES FOR TREATMENT OF DRUG-RESISTANT TUBERCULOSIS AND OTHER DISEASES
  申请人：Zamecnik Paul C.

  公开号：US20100204310A1

  公开（公告）日：2010-08-12

  The invention provides antibacterial compounds comprising an oligonucleotide having a sequence complementary to a translation initiation region of an mRNA encoding a mycolyl transferase of Mycobacterum tuberculosis selected from protein 30, 32A and 32B, and further having 5′ and 3′ palindromic hairpin-forming sequences, said compound being covalently linked to a protein synthesis inhibiting antibiotic via a linker. The invention further provides pharmaceutical formulations of such compounds and methods of use thereof for treating tuberculosis. Other diseases may similarly be treated by tethering and antibiotic which targets a ribosomal protein to an antisense oligonucleotide complementary to an mRNA involved in the disease.
• COMPOSITIONS OF MULTICATIONIC DRUGS FOR REDUCING INTERACTIONS WITH POLYANIONIC BIOMOLECULES AND METHODS OF USE THEREOF
  申请人：Insmed Incorporated

  公开号：US20140248335A1

  公开（公告）日：2014-09-04

  The present invention relates, in part, to a composition comprising a multicationic drug and an organic multianion. In some embodiments, the multicationic drug is enclosed within a carrier. In some embodiments, the carrier is a liposome. In some embodiments, the multicationic drug and organic multianion are enclosed within a carrier, while in other embodiments, the multicationic drug is enclosed within the carrier and the organic multianion is outside the carrier. The present invention also relates, in part, to a method of treating a subject for pulmonary distress comprising administering to a subject in need thereof the aforementioned composition.
• METHODS TO INHIBIT INTRACELLULAR GROWTH OF BACTERIA AND TO TREAT BACTERIA-MEDIATED DISEASES
  申请人：AGENCY FOR SCIENCE TECHNOLOGY AND RESEARCH

  公开号：US20150209308A1

  公开（公告）日：2015-07-30

  Disclosed is a method of preventing, treating or inhibiting bacterial infections. The method comprises administering at least one of the compounds disclosed herein. Also disclosed are methods of increasing acidity of bacterial phagosomes to inhibit bacterial growth, methods of increasing mitochondrial reactive oxygen species (mROS) generation to inhibit bacterial growth in a cell, pharmaceutical compositions and uses thereof.
• US9539222B2
  申请人：——

  公开号：US9539222B2

  公开（公告）日：2017-01-10