1-(4-hydroxy-3-methoxyphenyl)-5-(4-hydroxyphenyl)-(1E,4E)-1,4-pentadien-3-one | 148625-88-1

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂酸及其衍生物
• 英文名称: 1-(4-hydroxy-3-methoxyphenyl)-5-(4-hydroxyphenyl)-(1E,4E)-1,4-pentadien-3-one
• 英文别名: (1E,4E)-1-(4-hydroxy-3-methoxyphenyl)-5-(4-hydroxyphenyl)penta-1,4-dien-3-one；1-(4-hydroxy-3-methoxyphenyl)-5-(4-hydroxyphenyl)-penta-(1E,4E)-1,4-dien-3-one；(1E,4E)-1-(4-Hydroxy-3-methoxyphenyl)-5-(4-hydroxyphenyl)-1,4-pentadien-3-one
• CAS: 148625-88-1
• 化学式: C₁₈H₁₆O₄
• 分子量: 296.323
• InChiKey: QVRYUUYYIWAQHV-LUZURFALSA-N

物化性质

• 沸点：
  514.7±50.0 °C(Predicted)
• 密度：
  1.267±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  22
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  66.8
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  3-甲氧基-4-(甲氧基甲氧基)苯甲醛 在 sodium hydroxide 、 溶剂黄146 作用下， 以 乙醇 、 水 为溶剂， 反应 5.5h， 生成 1-(4-hydroxy-3-methoxyphenyl)-5-(4-hydroxyphenyl)-(1E,4E)-1,4-pentadien-3-one
  参考文献：
  名称：

  Anti-oxidative and anti-inflammatory curcumin-related phenolics from rhizomes of Curcuma domestica

  摘要：

  Two new natural phenolics were isolated from the rhizomes of Curcuma domestica along with four known curcuminoids. The structures of the former were determined to be 1,5-bis(4-hydroxy-3-methoxyphenyl)-penta-(1E,4E)-1,4-dien-3-one and 1-(4-hydroxy-3-methoxyphenyl)-5-(-4-hydroxyphenyl)-penta-(1E,4E)-1,4-dien-3-one, respectively, by spectral data and syntheses. Anti-oxidant activity of the phenolics was determined by the inhibition of autoxidation of linoleic acid in a water-alcohol system. Anti-inflammatory activity of the isolated compounds was determined on mouse cars by using a tumour promoter, TPA (12-O-tetradecanoylphorbol-13-acetate) as an inducer.

  DOI：

  10.1016/0031-9422(93)85179-u

文献信息

• Synthesis, Characterization, and Antioxidant Activity of Some 2-Methoxyphenols derivatives
  作者：Shaikha S. AlNeyadi、Naheed Amer、Tony G. Thomas、Ruba Al Ajeil、Priya Breitener、N Munawar

  DOI：10.1515/hc-2020-0112

  日期：2020.9.27

  candidates for preventing and treating conditions in which oxidative stress is a contributing factor. In this study, we report the design, synthesis and antioxidant activity of six compounds containing the 2-methoxyphenol moiety core structure. The synthesized derivatives were characterized using 1H NMR, 13C NMR, Fourier-transform infrared (FT-IR), and elemental analysis spectroscopy. The antioxidant properties

  摘要 氧化应激是糖尿病、动脉粥样硬化、癌症、神经退行性疾病和心血管疾病等多种疾病病理生理学的致病因素。治疗性抗氧化剂是预防和治疗氧化应激是一个促成因素的疾病的有希望的候选者。在这项研究中，我们报告了六种含有 2-甲氧基苯酚部分核心结构的化合物的设计、合成和抗氧化活性。合成的衍生物使用 1H NMR、13C NMR、傅里叶变换红外 (FT-IR) 和元素分析光谱进行表征。使用 2,2-二苯基-1-苦基-肼基-水合物 (DPPH)、2,2'-叠氮基-双(3-乙基苯并噻唑啉-6-磺酸 (ABTS) 和氧自由基吸收能力（ORAC）测定。
• POLYMERIC NANOPARTICLES COMPRISING TURMERIC
  申请人：XEROX CORPORATION

  公开号：US20150232642A1

  公开（公告）日：2015-08-20

  Disclosed herein are latex emulsion compositions comprising water, turmeric, at least one surfactant, and at least one organic monomer, wherein the latex emulsion composition has an average particle size of less than about 250 nm. Also disclosed herein are processes for preparing a latex emulsion composition comprising water, turmeric, at least one surfactant, and at least one organic monomer, wherein the latex emulsion composition has an average particle size of less than about 250 nm. Further disclosed herein is the use of turmeric-containing latex emulsion compositions as paints, inks, toners, cosmetics, health aids, beauty aids, foods, and coatings.
• Anti-oxidative and anti-inflammatory curcumin-related phenolics from rhizomes of Curcuma domestica
  作者：Toshiya Masuda、Akiko Jitoe、Junko Isobe、Nobuji Nakatani、Sigetomo Yonemori

  DOI：10.1016/0031-9422(93)85179-u

  日期：——

  Two new natural phenolics were isolated from the rhizomes of Curcuma domestica along with four known curcuminoids. The structures of the former were determined to be 1,5-bis(4-hydroxy-3-methoxyphenyl)-penta-(1E,4E)-1,4-dien-3-one and 1-(4-hydroxy-3-methoxyphenyl)-5-(-4-hydroxyphenyl)-penta-(1E,4E)-1,4-dien-3-one, respectively, by spectral data and syntheses. Anti-oxidant activity of the phenolics was determined by the inhibition of autoxidation of linoleic acid in a water-alcohol system. Anti-inflammatory activity of the isolated compounds was determined on mouse cars by using a tumour promoter, TPA (12-O-tetradecanoylphorbol-13-acetate) as an inducer.