1-Chloro-4-prop-2-enoxybut-2-yne | 208249-42-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-Chloro-4-prop-2-enoxybut-2-yne
• CAS: 208249-42-7
• 化学式: C₇H₉ClO
• mdl: MFCD19236027
• 分子量: 144.601
• InChiKey: BPIOGTDTRQFTSA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  9
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.428
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  4-(allyloxy)but-2-yn-1-ol 、 1-Chloro-4-prop-2-enoxybut-2-yne 在 sodium hydride 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 以82%的产率得到4,9,16-trioxa-1,16-heptadecadiene-6,11-diyne
  参考文献：
  名称：

  Ruthenium-Catalyzed Polycyclization Reactions

  摘要：

  The application of ruthenium alkylidenes such as 1 to the catalysis of polycyclization reactions is reported. Several acyclic precursors have been synthesized and reacted with 1. These precursors vary in topology and contain acetylenic and/or cycloolefinic metathesis relays. The cyclization reactions proceed in moderate to good yields to produce polycyclic polyenes when the precursors are subjected to catalytic amounts of 1. In general, precursors bearing n relay units generate polycycles containing (n + 1) rings.

  DOI：

  10.1021/jo972279g
• 作为产物：
  描述：

  4-(allyloxy)but-2-yn-1-ol 在 4-二甲氨基吡啶 、 三乙胺 、 对甲苯磺酰氯 作用下， 以 二氯甲烷 为溶剂， 生成 1-Chloro-4-prop-2-enoxybut-2-yne
  参考文献：
  名称：

  Ruthenium-Catalyzed Polycyclization Reactions

  摘要：

  The application of ruthenium alkylidenes such as 1 to the catalysis of polycyclization reactions is reported. Several acyclic precursors have been synthesized and reacted with 1. These precursors vary in topology and contain acetylenic and/or cycloolefinic metathesis relays. The cyclization reactions proceed in moderate to good yields to produce polycyclic polyenes when the precursors are subjected to catalytic amounts of 1. In general, precursors bearing n relay units generate polycycles containing (n + 1) rings.

  DOI：

  10.1021/jo972279g

文献信息

• Ruthenium-Catalyzed Polycyclization Reactions
  作者：William J. Zuercher、Matthias Scholl、Robert H. Grubbs

  DOI：10.1021/jo972279g

  日期：1998.6.1

  The application of ruthenium alkylidenes such as 1 to the catalysis of polycyclization reactions is reported. Several acyclic precursors have been synthesized and reacted with 1. These precursors vary in topology and contain acetylenic and/or cycloolefinic metathesis relays. The cyclization reactions proceed in moderate to good yields to produce polycyclic polyenes when the precursors are subjected to catalytic amounts of 1. In general, precursors bearing n relay units generate polycycles containing (n + 1) rings.