methyl 4-hydroxy-6-nitro-8-methoxy-quinoline-2-carboxylate | 77474-27-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: methyl 4-hydroxy-6-nitro-8-methoxy-quinoline-2-carboxylate
• 英文别名: Methyl-4-hydroxy-6-nitro-8-methoxy-quinoline-2-carboxylate；methyl 8-methoxy-6-nitro-4-oxo-1H-quinoline-2-carboxylate
• CAS: 77474-27-2
• 化学式: C₁₂H₁₀N₂O₆
• 分子量: 278.221
• InChiKey: DTAFSAJYAJNKDS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  20
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  110
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  methyl 4-hydroxy-6-nitro-8-methoxy-quinoline-2-carboxylate 在 5%-palladium/activated carbon 、 氢气 、 溶剂黄146 、 三溴氧磷 作用下， 以 四氢呋喃 、 1,4-二氧六环 、 乙酸乙酯 为溶剂， 反应 24.0h， 生成 methyl 6-amino-8-methoxy-4-(piperidin-1-yl)quinoline-2-carboxylate
  参考文献：
  名称：

  Design of quinoline-based fluorescent probe for the ratiometric detection of cadmium in aqueous media

  摘要：

  A new fluorescent probe, DQCd2, based on 4-piperidinoquinoline has been synthesized as a fluorescent probe for Cd2+. It can ratiometrically respond to Cd2+ in PBS buffer by a remarkable emission intensity enhancement (88-fold) and wavelength shift (70 nm). (C) 2013 Lin Xue and Hua Jiang. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.

  DOI：

  10.1016/j.cclet.2013.04.002
• 作为产物：
  描述：

  methyl 2-[(2-methoxy-4-nitro-phenyl)amino]-but-2-enedioate 以 二苯醚 为溶剂， 反应 0.33h， 以70%的产率得到methyl 4-hydroxy-6-nitro-8-methoxy-quinoline-2-carboxylate
  参考文献：
  名称：

  Design of quinoline-based fluorescent probe for the ratiometric detection of cadmium in aqueous media

  摘要：

  A new fluorescent probe, DQCd2, based on 4-piperidinoquinoline has been synthesized as a fluorescent probe for Cd2+. It can ratiometrically respond to Cd2+ in PBS buffer by a remarkable emission intensity enhancement (88-fold) and wavelength shift (70 nm). (C) 2013 Lin Xue and Hua Jiang. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.

  DOI：

  10.1016/j.cclet.2013.04.002

文献信息

• Compositions derived from quinoline and quinoxaline, preparation and use thereof
  申请人：Schmitt Martine

  公开号：US20060183909A1

  公开（公告）日：2006-08-17

  The present invention concerns compounds derived from quinoline and quinoxaline, their preparation and their uses, particularly in the field of therapeutics and vaccines or for developing active compounds. The inventive compounds are of general formula (I), and their pharmaceutically acceptable salts.

  本发明涉及从喹啉和喹喔啉衍生的化合物，它们的制备和用途，特别是在治疗和疫苗领域或用于开发活性化合物方面。本发明的化合物的一般式（I）及其药学上可接受的盐。