C.I. Acid Blue 74 | 860-22-0

• 物质功能分类: 原料药 - 诊断用药 - 器官功能检查剂
• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: C.I. Acid Blue 74
• 英文别名: indigo carmine；indigocarmine；sodium;(2Z)-3-oxo-2-(3-oxo-5-sulfonato-1H-indol-2-ylidene)-1H-indole-5-sulfonate
• CAS: 860-22-0
• 化学式: C₁₆H₈N₂O₈S₂*2Na
• 分子量: 466.36
• InChiKey: QCHDYDABSYZDLZ-HPWRNOGASA-L

物化性质

• 熔点：
  >300°C
• 密度：
  1.01 g/mL at 20 °C
• 溶解度：
  1g/l
• 最大波长(λmax)：
  608nm
• LogP：
  -3.57
• 稳定性/保质期：
  1. 在常温常压下保持稳定，应避免与氧化剂接触。

计算性质

• 辛醇/水分配系数(LogP)：
  -2.37
• 重原子数：
  29.0
• 可旋转键数：
  2.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  172.6
• 氢给体数：
  2.0
• 氢受体数：
  10.0

安全信息

• TSCA：
  Yes
• 危险品标志：
  Xn
• 安全说明：
  S22,S24/25
• 危险类别码：
  R22
• WGK Germany：
  3
• 海关编码：
  32041200
• 危险品运输编号：
  NONH for all modes of transport
• RTECS号：
  DU3000000
• 危险标志：
  GHS05
• 危险性描述：
  H290
• 危险性防范说明：
  P280,P305+P351+P338
• 储存条件：
  请将容器密封保存，并存放在阴凉干燥处。

SDS

Name:	Indigo Carmine (Cert.) Material Safety Data Sheet
Synonym:	Acid Blue 74; C.I. 73015; 5,5'-Indigodisulfonic acid, disodium salt
CAS:	860-22-0

Section 1 - Chemical Product MSDS Name:Indigo Carmine (Cert.) Material Safety Data Sheet
Synonym:Acid Blue 74; C.I. 73015; 5,5'-Indigodisulfonic acid, disodium salt

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Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS

CAS#	Chemical Name	content	EINECS#
860-22-0	C.I. Acid Blue 74	ca. 100	212-728-8

Hazard Symbols: XN
Risk Phrases: 22

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Section 3 - HAZARDS IDENTIFICATION
EMERGENCY OVERVIEW
Harmful if swallowed.The toxicological properties of this material have not been fully investigated.Light sensitive.
Potential Health Effects
Eye:
This product contains a cationic dye. Similar dyes have caused permanent injury to the cornea and conjunctiva in documented exposure cases with human or rabbit eyes.
Skin:
May cause skin irritation.
Ingestion:
May cause gastrointestinal irritation with nausea, vomiting and diarrhea. The toxicological properties of this substance have not been fully investigated. May be harmful if swallowed.
Inhalation:
May cause respiratory tract irritation. The toxicological properties of this substance have not been fully investigated.
Chronic:
No information found.

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Section 4 - FIRST AID MEASURES
Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
SPEEDY ACTION IS CRITICAL! Skin:
Get medical aid if irritation develops or persists. Flush skin with plenty of soap and water.
Ingestion:
If victim is conscious and alert, give 2-4 cupfuls of milk or water.
Never give anything by mouth to an unconscious person. Get medical aid.
Inhalation:
Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
Notes to Physician:

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Section 5 - FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion.
Extinguishing Media:
In case of fire, use water, dry chemical, chemical foam, or alcohol-resistant foam.

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Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Sweep up, then place into a suitable container for disposal. Avoid generating dusty conditions. Provide ventilation.

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Section 7 - HANDLING and STORAGE
Handling:
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Avoid contact with eyes, skin, and clothing. Avoid ingestion and inhalation. Store protected from light.
Storage:
Keep containers tightly closed. Store protected from light. Store in a cool, dry area away from incompatible substances.

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Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low.
Exposure Limits CAS# 860-22-0: Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant respirator use.

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Section 9 - PHYSICAL AND CHEMICAL PROPERTIES

Physical State: Solid
Color: dark blue
Odor: Not available.
pH: Not available.
Vapor Pressure: Negligible.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point: Not available.
Autoignition Temperature: Not applicable.
Flash Point: Not applicable.
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature: Not available.
Solubility in water: 1 g/100 mL @ 25C
Specific Gravity/Density: Not available.
Molecular Formula: C16H8N2Na2O8S2
Molecular Weight: 466.35

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Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Stable under normal temperatures and pressures.
Conditions to Avoid:
Incompatible materials, light.
Incompatibilities with Other Materials:
Oxidizing agents, nitric acid.
Hazardous Decomposition Products:
Nitrogen oxides, carbon monoxide, carbon dioxide, nitrogen.
Hazardous Polymerization: Will not occur.

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Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 860-22-0: DU3000000 LD50/LC50:
CAS# 860-22-0: Oral, mouse: LD50 = 2500 mg/kg; Oral, rat: LD50 = 2 gm/kg.
Carcinogenicity:
C.I. Acid Blue 74 - Not listed by ACGIH, IARC, or NTP.
Other:
See actual entry in RTECS for complete information.

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Section 12 - ECOLOGICAL INFORMATION

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Section 13 - DISPOSAL CONSIDERATIONS
Dispose of in a manner consistent with federal, state, and local regulations.

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Section 14 - TRANSPORT INFORMATION

IATA
Not regulated as a hazardous material.
IMO
Not regulated as a hazardous material.
RID/ADR
Not regulated as a hazardous material.

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Section 15 - REGULATORY INFORMATION

European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: XN
Risk Phrases:
R 22 Harmful if swallowed.
Safety Phrases:
WGK (Water Danger/Protection)
CAS# 860-22-0: 1
Canada
CAS# 860-22-0 is listed on Canada's DSL List.
CAS# 860-22-0 is not listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 860-22-0 is listed on the TSCA inventory.

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SECTION 16 - ADDITIONAL INFORMATION
N/A

制备方法与用途

鉴别试验

• 溶解性：溶于水；难溶于乙醇。按OT-42方法测定。
• 色素鉴别试验：按OT-16方法测定。

含量分析

• 按OT-15中方法二测定，试样量取1.4～1.5g，缓冲液由15g酒石酸氢钠配制。每mL0.1mol/L TiCl₃相当于色素总量0.02883g。

毒性

• ADI 0～5mg/kg（FAO/WHO，2001）。
• LD₅₀ > 2500mg/kg（小鼠，经口）。
• ADI未规定（FAO/wH0，2001）。暂定为0～5（EEC，1990，暂定）。
• 挪威、瑞士、芬兰、日本、加拿大、美国不准用。

使用限量

• GB 2760-2001(g/kg)：渍制小菜0.01；果汁(味)饮料类、碳酸饮料、配制酒、糖果、糕点上彩装、染色樱桃罐头(系装饰用)、青梅、糖果包衣、威化饼干夹心，0.10；红绿丝0.20；膨化食品、油炸食品，0.05。

化学性质

• 深绿色粉末或颗粒。溶于水，微溶于乙醇。

用途

• 用于食品、医药和日用化妆品的着色。
• 食用靛蓝为食用合成色素。
• 食用色素是用于食品着色的一类添加剂，包括合成色素和天然色素，总数逾60种。
• 一般用于调色。因其较不稳定，牢度低，染色性弱，最适宜于深色调。可调制成巧克力色、绿色、赤豆色、茶色、咖啡色。
• 用于糕饼、冷饮、清凉饮料，用量5～100mg/kg。

用途

• 作食品着色剂，我国规定可用于红绿丝中，最大使用量为0.20g/kg；在果汁(味)饮料类、碳酸饮料、配制酒、糖果、糕点上彩装、染色樱桃罐头(系装饰用)、青梅中，最大使用量0．10g/kg；在浸渍小菜中最大使用量为0.01g/kg。
• 氧化还原指示剂。检验牛奶的硝酸盐和氯酸盐的试剂。
• 生物染色剂，如尼基氏小体、细胞核的染色。
• 肾功能的测定等。

生产方法

• 靛蓝制备
  • 食用靛蓝实际上是靛蓝二磺酸二钠，由靛蓝用浓硫酸磺化，磺化结束后用水稀释，再用纯碱中和，最后加入氯化钠盐析，经过滤、水洗、干燥得成品。
• 靛蓝铝色淀制备
  • 由氯化铝、硫酸铝等的铝盐与碳酸钠等的碱类制取氢氧化铝，然后添加于靛蓝水溶液，沉淀而得产品。
• 生产方法
  • 用浓硫酸或与少量发烟硫酸合用，使靛蓝磺化后，用水适量稀释，经碳酸钠或氢氧化钠中和，以硫酸钠或氯化钠盐析，再经精制而得。
• 生产方法
  • 由靛蓝粉经浓硫酸磺化后，加水稀释，用碳酸钠中和，再经盐析，精制而得。每吨产品消耗靛蓝粉（100%）210kg。
• 生产方法
  • 由双二甲基氨基二苯基甲醇与2-羟基萘-3,6-二磺酸，在浓硫酸存在下，失去一分子水缩合成无色母体，在弱酸溶液中用二氧化锰氧化成三芳基甲烷色素。
    • 二苯基甲醇系由二氧化锰和硫酸氧化四烷基二氨基二苯基甲醇而得。可直接使用其离心分离的滤饼进行缩合。
    • 二氧化锰系由硫酸锰与高锰酸钾在碳酸钠溶液中新鲜制备而得。

反应信息

• 作为反应物：
  描述：

  C.I. Acid Blue 74 在 potassium bromate 作用下， 以 硫酸 为溶剂， 反应 24.0h， 生成 靛红-5-磺酸
  参考文献：
  名称：

  Jonnalagadda, Sreekantha B.; Simoyi, Reuben; Muthakia, Gerald K., Journal of the Chemical Society. Perkin transactions II, 1988, p. 1111 - 1116

  摘要：

  DOI：

文献信息

• Jonnalagadda, Sreekantha B.; Simoyi, Reuben; Muthakia, Gerald K., Journal of the Chemical Society. Perkin transactions II, 1988, p. 1111 - 1116
  作者：Jonnalagadda, Sreekantha B.、Simoyi, Reuben、Muthakia, Gerald K.

  DOI：——

  日期：——