(Z)-1-(4-chlorophenyl)-2-(1H-imidazol-1-yl)-4,4-dimethylpent-1-en-3-one | 86503-40-4

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂酸及其衍生物
• 英文名称: (Z)-1-(4-chlorophenyl)-2-(1H-imidazol-1-yl)-4,4-dimethylpent-1-en-3-one
• 英文别名: (Z)-1-(4-chlorophenyl)-2-imidazol-1-yl-4,4-dimethylpent-1-en-3-one
• CAS: 86503-40-4
• 化学式: C₁₆H₁₇ClN₂O
• 分子量: 288.777
• InChiKey: QCOHHPYVHYIJPA-UVTDQMKNSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  20
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  34.9
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (Z)-1-(4-chlorophenyl)-2-(1H-imidazol-1-yl)-4,4-dimethylpent-1-en-3-one 以 丙酮 为溶剂， 反应 2.5h， 以2.7 g的产率得到(E)-1-(4-chlorophenyl)-2-(1H-imidazol-1-yl)-4,4-dimethylpent-1-en-3-one
  参考文献：
  名称：

  Structure–activity relationship of uniconazole, a potent inhibitor of ABA 8′-hydroxylase, with a focus on hydrophilic functional groups and conformation

  摘要：

  The plant growth retardant S-(+)-uniconazole (UNI-OH) is a strong inhibitor of abscisic acid (ABA) 8'-hydroxylase, a key enzyme in the catabolism of ABA, a plant hormone involved in stress tolerance, stomata] closure, flowering, seed dormancy, and other physiological events. In the present study, we focused on the two polar sites of UNI-OH and synthesized 3- and 2 ''-modified analogs. Conformational analysis and an in vitro enzyme inhibition assay yielded new findings on the structure-activity relationship of UNI-OH: (1) by substituting imidazole for triazole, which increases affinity to heme iron, we identified a more potent compound, IMI-OH; (2) the polar group at the 3-position increases affinity for the active site by electrostatic or hydrogen-bonding interactions; (3) the conformer preference for a polar environment partially contributes to affinity for the active site. These findings should be useful for designing potent azole-containing specific inhibitors of ABA 8'-hydroxylase. (C) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2007.12.019
• 作为产物：
  描述：

  4-氯苯甲醛 、 1-(1H-imidazol-1-yl)-3,3-dimethylbutan-2-one 在 potassium carbonate 作用下， 以 乙酸酐 为溶剂， 反应 1.0h， 以80%的产率得到(Z)-1-(4-chlorophenyl)-2-(1H-imidazol-1-yl)-4,4-dimethylpent-1-en-3-one
  参考文献：
  名称：

  Structure–activity relationship of uniconazole, a potent inhibitor of ABA 8′-hydroxylase, with a focus on hydrophilic functional groups and conformation

  摘要：

  The plant growth retardant S-(+)-uniconazole (UNI-OH) is a strong inhibitor of abscisic acid (ABA) 8'-hydroxylase, a key enzyme in the catabolism of ABA, a plant hormone involved in stress tolerance, stomata] closure, flowering, seed dormancy, and other physiological events. In the present study, we focused on the two polar sites of UNI-OH and synthesized 3- and 2 ''-modified analogs. Conformational analysis and an in vitro enzyme inhibition assay yielded new findings on the structure-activity relationship of UNI-OH: (1) by substituting imidazole for triazole, which increases affinity to heme iron, we identified a more potent compound, IMI-OH; (2) the polar group at the 3-position increases affinity for the active site by electrostatic or hydrogen-bonding interactions; (3) the conformer preference for a polar environment partially contributes to affinity for the active site. These findings should be useful for designing potent azole-containing specific inhibitors of ABA 8'-hydroxylase. (C) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2007.12.019

文献信息

• US4203995A
  申请人：——

  公开号：US4203995A

  公开（公告）日：1980-05-20
• Structure–activity relationship of uniconazole, a potent inhibitor of ABA 8′-hydroxylase, with a focus on hydrophilic functional groups and conformation
  作者：Yasushi Todoroki、Kyotaro Kobayashi、Hidetaka Yoneyama、Saori Hiramatsu、Mei-Hong Jin、Bunta Watanabe、Masaharu Mizutani、Nobuhiro Hirai

  DOI：10.1016/j.bmc.2007.12.019

  日期：2008.3.15

  The plant growth retardant S-(+)-uniconazole (UNI-OH) is a strong inhibitor of abscisic acid (ABA) 8'-hydroxylase, a key enzyme in the catabolism of ABA, a plant hormone involved in stress tolerance, stomata] closure, flowering, seed dormancy, and other physiological events. In the present study, we focused on the two polar sites of UNI-OH and synthesized 3- and 2 ''-modified analogs. Conformational analysis and an in vitro enzyme inhibition assay yielded new findings on the structure-activity relationship of UNI-OH: (1) by substituting imidazole for triazole, which increases affinity to heme iron, we identified a more potent compound, IMI-OH; (2) the polar group at the 3-position increases affinity for the active site by electrostatic or hydrogen-bonding interactions; (3) the conformer preference for a polar environment partially contributes to affinity for the active site. These findings should be useful for designing potent azole-containing specific inhibitors of ABA 8'-hydroxylase. (C) 2007 Elsevier Ltd. All rights reserved.