2-[(1E,3E,5E,7E)-9,9-diethoxy-3,7-dimethylnona-1,3,5,7-tetraenyl]-1,3,3-trimethylcyclohexene | 72612-82-9

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: 2-[(1E,3E,5E,7E)-9,9-diethoxy-3,7-dimethylnona-1,3,5,7-tetraenyl]-1,3,3-trimethylcyclohexene
• CAS: 72612-82-9
• 化学式: C₂₄H₃₈O₂
• 分子量: 358.565
• InChiKey: QBFQVZSULFGJTN-VVYUTNTRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.9
• 重原子数：
  26
• 可旋转键数：
  9
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.58
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-[(1E,3E,5E,7E)-9,9-diethoxy-3,7-dimethylnona-1,3,5,7-tetraenyl]-1,3,3-trimethylcyclohexene 在 N-溴代丁二酰亚胺(NBS) 作用下， 以 四氯化碳 为溶剂， 生成 6-bromo-2-[(1E,3E,5E,7E)-9,9-diethoxy-3,7-dimethylnona-1,3,5,7-tetraenyl]-1,3,3-trimethylcyclohexene
  参考文献：
  名称：

  WO2006/91796

  摘要：

  公开号：
• 作为产物：
  描述：

  乙醇 、 视黄醛 在 对甲苯磺酸 作用下， 生成 2-[(1E,3E,5E,7E)-9,9-diethoxy-3,7-dimethylnona-1,3,5,7-tetraenyl]-1,3,3-trimethylcyclohexene
  参考文献：
  名称：

  WO2006/91796

  摘要：

  公开号：

文献信息

• Retinal, derivatives and their therapeutic use
  申请人：Yu, Ruey J., Dr.

  公开号：EP0391033A2

  公开（公告）日：1990-10-10

  Therapeutic as well as preventive measures to improve cosmetic conditions and to alleviate the symptoms of dermatologic disorders with retinal and its derivatives is disclosed. Cosmetic conditions and dermatologic disorders in humans and domestic animals in which retinal and its derivatives may be useful include age spots, wrinkles, warts, eczema, seborrheic keratoses, acne, oily skin, psoriasis, dandruff, xerosis, inflammatory and pruritic skin, disturbed keratinization, skin changes associated with aging and possibly viral infections. Retinal and its derivatives include their stereoisomers, for example, all-trans, 13-cis, 11-cis, 9-cis, 7-cis, 11,13-cis and 9,13-cis vitamin A aldehydes, their hydrate, hemiacetal and acetal forms, and their adduct compounds. Compositions containing retinal or its derivative may be administered systemically such as orally, or topically to the affected areas of the skin.

  本研究公开了用视黄醛及其衍生物改善美容状况和减轻皮肤病症状的治疗和预防措施。视黄醛及其衍生物可用于治疗的人类和家畜的美容状况和皮肤病包括老年斑、皱纹、疣、湿疹、脂溢性角化病、痤疮、油性皮肤、牛皮癣、头皮屑、干燥症、炎症性和瘙痒性皮肤、角化紊乱、与衰老有关的皮肤变化以及可能的病毒感染。视黄醛及其衍生物包括它们的立体异构体，例如全反式、13-顺式、11-顺式、9-顺式、7-顺式、11,13-顺式和 9,13- 顺式维生素 A 醛，它们的水合物、半缩醛和缩醛形式，以及它们的加合物。含有视黄醛或其衍生物的复合物可全身给药，如口服，或局部用于皮肤的受影响部位。
• REGULATORY T CELLS AND METHODS OF MAKING AND USING SAME
  申请人：LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGY

  公开号：EP2167647A2

  公开（公告）日：2010-03-31
• Treatment of Dermatologic Skin Disorders
  申请人：Johnson Benjamin

  公开号：US20120141576A1

  公开（公告）日：2012-06-07

  Retinal and its derivatives are incorporated with liposomes in therapeutic compositions for topical application to prevent or alleviate the conditions and symptoms of cosmetic and dermatologic disorders are described as follows. In particular, retinal and its derivatives are combined with liposomes to increase the penetration of the retinal into the skin, to provide hydration of the skin during treatment, to reduce irritation of the skin during the application of the retinal, for use as a chemical skin peel and other embodiments and uses. The present invention includes utilizing retinol products, and particularly retinal in combination with liposomes each of these embodiments and uses separately as well as in combinations with one another.
• TREATMENT PRODUCT AND METHOD
  申请人：Johnson Benjamin

  公开号：US20130149362A1

  公开（公告）日：2013-06-13

  Treatment products and methods are disclosed. An example treatment product may be used for treating skin disorders by stimulating the dermis and epidermis skin layers. The example treatment product may have a composition of retinal in the amount of at least 0.15% by weight, and a liposome surrounding the retinal.
• US5093360A
  申请人：——

  公开号：US5093360A

  公开（公告）日：1992-03-03