3-dimethylamino-6,7-dimethoxyquinoline | 87199-61-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 3-dimethylamino-6,7-dimethoxyquinoline
• 英文别名: 6,7-dimethoxy-N,N-dimethylquinolin-3-amine
• CAS: 87199-61-9
• 化学式: C₁₃H₁₆N₂O₂
• 分子量: 232.282
• InChiKey: QKJYKAACWVYXAL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  34.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  3-dimethylamino-6,7-dimethoxyquinoline 在 palladium on activated charcoal 氢气 、 溶剂黄146 作用下， 80.0 ℃ 、399.99 kPa 条件下， 生成 3-dimethylamino-6,7-dimethoxy-1,2,3,4-tetrahydroquinoline
  参考文献：
  名称：

  Synthesis and positive inotropic effect of 1-alkyl- and 1-acyl-6,7-dimethoxy-3-dimethylamino-1,2,3,4-tetrahydroquinolines

  摘要：

  In the search for new positive inotropic agents we have investigated a series of 3-dimethylamino-1,2,3,4-tetrahydroquinolines with various substituents on the nitrogen of the quinoline ring. The N-isobutyryl derivative 20 (S903) was selected as the most interesting compound. Interestingly, while cardiac contractility was increased in vitro, heart rate was unchanged or slightly decreased. The positive inotropic activity was partly dependent on an indirect sympathomimetic effect. The (S) absolute configuration of the (-)enantiomer of S903 was established by correlation with (S)-L-dopa.

  DOI：

  10.1016/0223-5234(94)90110-4
• 作为产物：
  描述：

  聚合甲醛 、 3-amino-6,7-dimethoxyquinoline 在 甲酸 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 6.0h， 以95%的产率得到3-dimethylamino-6,7-dimethoxyquinoline
  参考文献：
  名称：

  Synthesis and positive inotropic effect of 1-alkyl- and 1-acyl-6,7-dimethoxy-3-dimethylamino-1,2,3,4-tetrahydroquinolines

  摘要：

  In the search for new positive inotropic agents we have investigated a series of 3-dimethylamino-1,2,3,4-tetrahydroquinolines with various substituents on the nitrogen of the quinoline ring. The N-isobutyryl derivative 20 (S903) was selected as the most interesting compound. Interestingly, while cardiac contractility was increased in vitro, heart rate was unchanged or slightly decreased. The positive inotropic activity was partly dependent on an indirect sympathomimetic effect. The (S) absolute configuration of the (-)enantiomer of S903 was established by correlation with (S)-L-dopa.

  DOI：

  10.1016/0223-5234(94)90110-4

文献信息

• N.sub.1 -Acyl-3-amino-1,2,3,4-tetrahydroquinoline compounds active on
  申请人：Simes

  公开号：US04507307A1

  公开（公告）日：1985-03-26

  N.sub.1 -acyl-3-amino-1,2,3,4-tetrahydroquinoline compounds active on the cardiocirculatory system, pharmaceutically acceptable salts thereof, pharmaceutical compositions containing the new compounds and some intermediates useful in the preparation of the new tetrahydroquinoline compounds. Process for preparing the new tetrahydroquinoline compounds and some intermediates useful in the preparation thereof.

  N.sub.1-酰基-3-氨基-1,2,3,4-四氢喹啉化合物对心血管系统具有活性，其药学上可接受的盐，含有新化合物的制药组合物以及用于制备新四氢喹啉化合物的一些中间体。制备新四氢喹啉化合物和一些在制备过程中有用的中间体的方法。
• N1-acyl-3-amino-1,2,3,4-tetrahydroquinoline compounds
  申请人：SIMES S.p.A. Società Italiana Medicinali e Sintetici

  公开号：EP0072070A2

  公开（公告）日：1983-02-16

  N,-acyl-3-amino-1,2,3,4-tetrahydroquinoline compounds acting on the cardiocirculatory system, pharmaceutically acceptable salts thereof, pharmaceutical compositions containing the new compounds and some intermediates useful in the preparation of the new tetrahydroquinoline compounds. Process for preparing the new tetrahydroquinoline compounds and some intermediates useful in the preparation thereof.

  N,-酰基-3-氨基-1,2,3,4-四氢喹啉化合物、其药学上可接受的盐、含有新化合物的药物组合物以及一些用于制备新四氢喹啉化合物的中间体。 制备新四氢喹啉化合物及其制备过程中有用的一些中间体的工艺。
• US4507307A
  申请人：——

  公开号：US4507307A

  公开（公告）日：1985-03-26
• Synthesis and positive inotropic effect of 1-alkyl- and 1-acyl-6,7-dimethoxy-3-dimethylamino-1,2,3,4-tetrahydroquinolines
  作者：F SANTANGELO、C CASAGRANDE、G MIRAGOLI、V VECCHIETTI

  DOI：10.1016/0223-5234(94)90110-4

  日期：——

  In the search for new positive inotropic agents we have investigated a series of 3-dimethylamino-1,2,3,4-tetrahydroquinolines with various substituents on the nitrogen of the quinoline ring. The N-isobutyryl derivative 20 (S903) was selected as the most interesting compound. Interestingly, while cardiac contractility was increased in vitro, heart rate was unchanged or slightly decreased. The positive inotropic activity was partly dependent on an indirect sympathomimetic effect. The (S) absolute configuration of the (-)enantiomer of S903 was established by correlation with (S)-L-dopa.