1-(4-chlorophenyl)-3-(3-nitrophenyl)-3-phenylsulfenylpropan-1-one | 1422437-19-1

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 直链 1,3-二芳基丙烷
• 英文名称: 1-(4-chlorophenyl)-3-(3-nitrophenyl)-3-phenylsulfenylpropan-1-one
• 英文别名: 1-(4-Chlorophenyl)-3-(3-nitrophenyl)-3-phenylsulfanylpropan-1-one；1-(4-chlorophenyl)-3-(3-nitrophenyl)-3-phenylsulfanylpropan-1-one
• CAS: 1422437-19-1
• 化学式: C₂₁H₁₆ClNO₃S
• 分子量: 397.882
• InChiKey: JANGQDUIKXFIRW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.7
• 重原子数：
  27
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  88.2
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  1-(4-chlorophenyl)-3-(3-nitrophenyl)-3-phenylsulfenylpropan-1-one 在 间氯过氧苯甲酸 作用下， 以 二氯甲烷 为溶剂， 以88%的产率得到3-(Benzenesulfonyl)-1-(4-chlorophenyl)-3-(3-nitrophenyl)propan-1-one
  参考文献：
  名称：

  Synthesis and antibacterial and antifungal evaluation of some chalcone based sulfones and bisulfones

  摘要：

  Two series of chalcone based sulfone and bisulfone derivatives were synthesized using chalcone, thiophenol and sodium metal at room temperature, followed by oxidation of chalcone sulfides with m-CPBA at 0 degrees C in a novel method. Both sulfones and bisulfones were evaluated for their antimicrobial activities against Aspergillus niger and Candida albicans (yeast), Bacillus subtilis and Staphylococcus aureus (Gram (+) bacteria) and Pseudomonas aeruginosa and Salmonella typhimurium (Gram (-) bacteria) strains. Among them, compounds 2c, 3c, 6c, 7c, 8c and 9c have shown high antifungal activity against C albicans compare to reference drugs viz. Amphotericin-B and Nystatin. Compound 1c has shown slightly better antibacterial activity against B. subtilis and compounds 5c, 6c and 7c have shown excellent antibacterial activity against S. typhimurium in compare to reference drugs Ampicillin and Kanamycin. (C) 2012 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2012.09.004
• 作为产物：
  描述：

  1-(4-chlorophenyl)-3-(3-nitrophenyl)prop-2-en-1-one 、 苯硫酚 在 sodium 作用下， 以 二氯甲烷 为溶剂， 反应 3.0h， 以92%的产率得到1-(4-chlorophenyl)-3-(3-nitrophenyl)-3-phenylsulfenylpropan-1-one
  参考文献：
  名称：

  Synthesis and antibacterial and antifungal evaluation of some chalcone based sulfones and bisulfones

  摘要：

  Two series of chalcone based sulfone and bisulfone derivatives were synthesized using chalcone, thiophenol and sodium metal at room temperature, followed by oxidation of chalcone sulfides with m-CPBA at 0 degrees C in a novel method. Both sulfones and bisulfones were evaluated for their antimicrobial activities against Aspergillus niger and Candida albicans (yeast), Bacillus subtilis and Staphylococcus aureus (Gram (+) bacteria) and Pseudomonas aeruginosa and Salmonella typhimurium (Gram (-) bacteria) strains. Among them, compounds 2c, 3c, 6c, 7c, 8c and 9c have shown high antifungal activity against C albicans compare to reference drugs viz. Amphotericin-B and Nystatin. Compound 1c has shown slightly better antibacterial activity against B. subtilis and compounds 5c, 6c and 7c have shown excellent antibacterial activity against S. typhimurium in compare to reference drugs Ampicillin and Kanamycin. (C) 2012 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2012.09.004

文献信息

• Synthesis and antibacterial and antifungal evaluation of some chalcone based sulfones and bisulfones
  作者：Naveen Kumar Konduru、Sunita Dey、Mohammad Sajid、Mohammad Owais、Naseem Ahmed

  DOI：10.1016/j.ejmech.2012.09.004

  日期：2013.1

  Two series of chalcone based sulfone and bisulfone derivatives were synthesized using chalcone, thiophenol and sodium metal at room temperature, followed by oxidation of chalcone sulfides with m-CPBA at 0 degrees C in a novel method. Both sulfones and bisulfones were evaluated for their antimicrobial activities against Aspergillus niger and Candida albicans (yeast), Bacillus subtilis and Staphylococcus aureus (Gram (+) bacteria) and Pseudomonas aeruginosa and Salmonella typhimurium (Gram (-) bacteria) strains. Among them, compounds 2c, 3c, 6c, 7c, 8c and 9c have shown high antifungal activity against C albicans compare to reference drugs viz. Amphotericin-B and Nystatin. Compound 1c has shown slightly better antibacterial activity against B. subtilis and compounds 5c, 6c and 7c have shown excellent antibacterial activity against S. typhimurium in compare to reference drugs Ampicillin and Kanamycin. (C) 2012 Elsevier Masson SAS. All rights reserved.