Retinol, 9,12-octadecadienoate, (Z,Z)- | 631-89-0

• 物质功能分类: 有机原料 - 羧酸类化合物及衍生物
• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: Retinol, 9,12-octadecadienoate, (Z,Z)-
• 英文别名: [(2Z,4E,6Z,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraenyl] (9Z,12Z)-octadeca-9,12-dienoate
• CAS: 631-89-0
• 化学式: C₃₈H₆₀O₂
• 分子量: 548.9
• InChiKey: XJKITIOIYQCXQR-DOTGLYPQSA-N

物化性质

• 沸点：
  631.0±34.0 °C(Predicted)
• 密度：
  0.929±0.06 g/cm3(Predicted)
• LogP：
  14.529 (est)

计算性质

• 辛醇/水分配系数(LogP)：
  13
• 重原子数：
  40
• 可旋转键数：
  21
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.61
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  维生素 A 醋酸酯 、 (Z,Z)-9,12-十八烷二烯酸二聚物 在 三乙胺 、 甲苯 、 维生素 A 醋酸酯 、 (Z,Z)-9,12-十八烷二烯酸二聚物 作用下， 以 甲苯 为溶剂， 反应 27.0h， 生成 Retinol, 9,12-octadecadienoate, (Z,Z)-
  参考文献：
  名称：

  Preparation of retinyl esters

  摘要：

  长链维生素A酯类化合物通过化学酶法制备，从短链维生素A酯类和适当的长链酸或酯类在酶的存在下反应。使用不同的添加剂可以提高所需酯类的产率，并促进其纯化。

  公开号：

  US20080085534A1

文献信息

• Topical composition and use thereof for the prophylaxis and the treatment of defects connected to inflammatory dermopathies
  申请人：Skinius S.R.L.

  公开号：EP2387990A1

  公开（公告）日：2011-11-23

  The invention refers to a topical composition and to its use for the prophylaxis and the treatment of defects connected to inflammatory dermopathies. Particularly, the invention pertains to a topical composition comprising at least an alum, 18-β-glycyrrhetic acid and/or one derivative thereof, and vitamin A and/or one derivative thereof, and the use of such composition for the prophylaxis and the treatment of inflammatory dermopathies, preferably of the seborrhoeic dermatitis and of those affections in which the presence of an excess of sebum occurs.

  本发明涉及一种外用组合物及其用于预防和治疗与炎症性皮肤病有关的缺陷的用途。特别是，本发明涉及一种外用组合物，该组合物至少包含明矾、18-β-甘草亭酸和/或其衍生物，以及维生素 A 和/或其衍生物，该组合物还可用于预防和治疗炎症性皮肤病，尤其是脂溢性皮炎和皮脂过多的皮肤病。
• TOPICAL COMPOSITION AND USE THEREOF FOR THE PROPHYLAXIS AND THE TREATMENT OF DEFECTS CONNECTED TO INFLAMMATORY DERMOPATHIES
  申请人：Skinius S.R.L.

  公开号：EP2566455B1

  公开（公告）日：2018-09-12
• Topical Composition and Use Thereof for the Prophylaxis and the Treatment of Defects Connected to Inflammatory Dermopathies
  申请人：DiPietro Antonio

  公开号：US20130101686A1

  公开（公告）日：2013-04-25

  A topical composition and its use for the prophylaxis and the treatment of defects connected to inflammatory dermopathies. Particularly, a topical composition including at least an alum, 18-β-glycyrrhetic acid and/or one derivative thereof, and vitamin A and/or one derivative thereof, and the use of such composition for the prophylaxis and the treatment of inflammatory dermopathies, preferably of the seborrhoeic dermatitis and of those affections in which the presence of an excess of sebum occurs.
• US8821904B2
  申请人：——

  公开号：US8821904B2

  公开（公告）日：2014-09-02
• [EN] TOPICAL COMPOSITION AND USE THEREOF FOR THE PROPHYLAXIS AND THE TREATMENT OF DEFECTS CONNECTED TO INFLAMMATORY DERMOPATHIES<br/>[FR] COMPOSITION TOPIQUE ET SON UTILISATION POUR LA PROPHYLAXIE ET LE TRAITEMENT DE DÉFAUTS LIÉS À DES DERMATOSES INFLAMMATOIRES
  申请人：SKINIUS S R L

  公开号：WO2011138364A1

  公开（公告）日：2011-11-10

  The invention refers to a topical composition and to its use for the prophylaxis and the treatment of defects connected to inflammatory dermopathies. Particularly, the invention pertains to a topical composition comprising at least an alum, 18-β-glycyrrhetic acid and/or one derivative thereof, and vitamin A and/or one derivative thereof, and the use of such composition for the prophylaxis and the treatment of inflammatory dermopathies, preferably of the seborrhoeic dermatitis and of those affections in which the presence of an excess of sebum occurs.