3-(1-hexynyl)-2-cyclohexen-1-one | 130647-12-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 3-(1-hexynyl)-2-cyclohexen-1-one
• 英文别名: 3-Hex-1-ynylcyclohex-2-en-1-one
• CAS: 130647-12-0
• 化学式: C₁₂H₁₆O
• 分子量: 176.258
• InChiKey: WBDYUWNZNNPQRI-UHFFFAOYSA-N

物化性质

• 沸点：
  275.8±30.0 °C(Predicted)
• 密度：
  0.97±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.58
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  3-(1-hexynyl)-2-cyclohexen-1-one 在 bis(ethylene)rhodium(I) chloride dimer (R)-(+)-2-二苯膦-2'-甲氧基-1,1'-联萘 、 甲基锂 作用下， 以 四氢呋喃 、 乙醚 为溶剂， 反应 14.5h， 生成 3-(2-phenylhex-1-enylidene)-1-(trifluoromethanesulfonyloxy)cyclohexene
  参考文献：
  名称：

  Rhodium-Catalyzed Asymmetric 1,6-Addition of Aryltitanates to Enynones Giving Axially Chiral Allenes

  摘要：

  [GRAPHICS]The addition of aryltitanate reagents ArTi(OPr-i)(4)Li to 3-alkynyl-2-en-1-ones in the presence of chlorotrimethylsilane and a rhodium-(R)-segphos as a catalyst proceeded in a 1,6-fashion to give a high yield of axially chiral allenylalkenyl silyl enol ethers with up to 93% ee.

  DOI：

  10.1021/ol036309f
• 作为产物：
  描述：

  1-(hex-1-ynyl)cyclohex-2-enol 在 sodium periodate 、 2,2,6,6-四甲基哌啶氧化物 、 silica gel 作用下， 以 二氯甲烷 为溶剂， 生成 3-(1-hexynyl)-2-cyclohexen-1-one
  参考文献：
  名称：

  NHC-Cu催化与格氏试剂在多共轭环烯酮上的不对称共轭加成反应形成季立体中心

  摘要：

  据报道，各种格氏试剂在铜催化下将共轭加成物加到共轭烯酮（二烯酮和烯酮衍生物）上。由三氟甲磺酸铜和NHC配体组成的催化剂体系导致1,4加成产物的异常选择性形成。该反应可以创建对映异构体过量高达99％的全碳手性四元中心。1,4加合物上剩余的不饱和基团使您可以进行有价值的合成转化。

  DOI：

  10.1002/chem.201200502

文献信息

• Highly Enantioselective and Regioselective Copper-Catalyzed 1,4 Addition of Grignard Reagents to Cyclic Enynones
  作者：Matthieu Tissot、Alexandra Pérez Hernández、Daniel Müller、Marc Mauduit、Alexandre Alexakis

  DOI：10.1021/ol200219m

  日期：2011.3.18

  regioselectivity with respect to copper-catalyzed conjugate additions of various Grignard reagents to cyclic enynones. The use of Cu(OTf)2 and NHC ligand L1 as the catalyst combination in CH2Cl2 led to the unique formation of the 1,4 adduct. This selectivity does not follow the general trend previously observed in the literature using extended Michael acceptors. Moreover these reactions allowed for the creation

  在这封信中，我们描述了相对于铜催化的各种格氏试剂向环烯酮的铜催化共轭加成的区域选择性方面的不同寻常的结果。Cu（OTf）2和NHC配体L1作为CH 2 Cl 2中的催化剂组合的使用导致1,4加合物的独特形成。这种选择性不符合以前使用扩展的迈克尔受体在文献中观察到的一般趋势。此外，这些反应允许建立具有高达97％ee的对映选择性的四元立体学中心。
• Preparation and reactivity of functionalized alkenyl-zinc, -copper, and -chromium organometallics
  作者：Paul Knochel、C. Janakiram Rao

  DOI：10.1016/s0040-4020(01)80504-4

  日期：1993.1

  Beta-halogeno-alpha,beta-unsaturated carbonyl derivatives were converted to the corresponding zinc organometallics 2a under mild conditions in THF (Zn dust, 25-45-degrees-C, 1-4h). These functionalized alkenylzinc iodides react with a variety of alkenyl and aromatic iodides affording the desired coupling products in 40-97% yield. The addition of a THF solution of CuCN.2LiCl to 2a affords the corresponding organocopper derivatives 2b which react with electrophiles, such as alkynyl and allylic halides, nitro olefins, enones, and chlorotrimethylstannane providing polyfunctional unsaturated carbonyl compounds in 71-95% yield. The insertion of chromium (II) chloride to beta-iodo and to some beta-(p-tosyl)enones in DMF furnishes new functionalized chromium (III) organometallics 2c which react with aldehydes providing gamma-hydroxy unsaturated carbonyl derivatives in 40-91% yield. The synthetic scope and the limitations of this methodology are discussed.
• A direct preparation of vinylogous acyl anion equivalents
  作者：C. Janakiram Rao、Paul Knochel

  DOI：10.1021/jo00015a004

  日期：1991.7

  Unmasked vinylogous acyl anion equivalents 2 were prepared by the insertion of zinc to various beta-halo, alpha,beta-unsaturated ketones and esters 1. The new reagents 2 react with various electrophiles in the presence of CuCN.2LiCl or catalytic amounts of Pd(0) complexes in excellent yields.
• RAO, C. JANAKIRAM;KNOCHEL, PAUL, J. ORG. CHEM., 56,(1991) N5, C. 4593-4596
  作者：RAO, C. JANAKIRAM、KNOCHEL, PAUL

  DOI：——

  日期：——
• Formation of Quaternary Stereogenic Centers by NHC-Cu-Catalyzed Asymmetric Conjugate Addition Reactions with Grignard Reagents on Polyconjugated Cyclic Enones
  作者：Matthieu Tissot、Daniele Poggiali、Hélène Hénon、Daniel Müller、Laure Guénée、Marc Mauduit、Alexandre Alexakis

  DOI：10.1002/chem.201200502

  日期：2012.7.9

  The copper‐catalyzed conjugate addition of various Grignard reagents to polyconjugated enones (dienone and enynone derivatives) is reported. The catalyst system, composed of copper triflate and an NHC ligand, led to the unusual selective formation of the 1,4‐addition products. This reaction allows for the creation of all‐carbon chiral quaternary centers with enantiomeric excesses up to 99 %. The remaining

  据报道，各种格氏试剂在铜催化下将共轭加成物加到共轭烯酮（二烯酮和烯酮衍生物）上。由三氟甲磺酸铜和NHC配体组成的催化剂体系导致1,4加成产物的异常选择性形成。该反应可以创建对映异构体过量高达99％的全碳手性四元中心。1,4加合物上剩余的不饱和基团使您可以进行有价值的合成转化。