(3aR^*,4S^*,7S^*,7aR^*)-2,3,3a,4,5,6,7,7a-octahydro-4,7-methano-1H-inden-5-one | 31351-12-9

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: (3aR^*,4S^*,7S^*,7aR^*)-2,3,3a,4,5,6,7,7a-octahydro-4,7-methano-1H-inden-5-one
• 英文别名: 5,6-endo-trimethylene-2-norbornanone；endo-tricyclo<5.2.1.0².⁶>decan-8-one；endo-5,6-Trimethylene-2-norbornanone；tricyclo<5.2.1.0^2.6>decan-9-one；(+/-)-5-oxo-(3arH.7acH)-hexahydro-4c.7c-methano-indan；(3aα,4α,7α,7aα)-octahydro-4,7-methano-5H-inden-5-one；(3aSR,4RS,7RS,7aSR)-(±)-octahydro-5H-4,7-methanoinden-5-one；(3aalpha,4alpha,7alpha,7aalpha)-Octahydro-4,7-methano-5H-inden-5-one；(1S,2R,6R,7S)-tricyclo[5.2.1.02,6]decan-8-one
• CAS: 31351-12-9
• 化学式: C₁₀H₁₄O
• 分子量: 150.221
• InChiKey: OMIDXVJKZCPKEI-KDXUFGMBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  11
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

安全信息

• 海关编码：
  2914299000

反应信息

• 作为反应物：
  描述：

  (3aR^*,4S^*,7S^*,7aR^*)-2,3,3a,4,5,6,7,7a-octahydro-4,7-methano-1H-inden-5-one 在 氢氧化钾 、 potassium permanganate 作用下， 生成 (1R,3S,3aR,6aS)-octahydropentalene-1,3-dicarboxylic acid
  参考文献：
  名称：

  Aliphatic semidiones. XXV. Bicyclo[n.2.1]alkane-2,3-semidiones

  摘要：

  DOI：

  10.1021/ja00830a012
• 作为产物：
  描述：

  (3aR^*,4S^*,7R^*,7aS^*)-2,3,3a,4,7,7a-hexahydro-4,7-methano-1H-indene 在 sodium hydroxide 、 dimethyl sulfide borane 、 双氧水 、 pyridinium chlorochromate 作用下， 以 二氯甲烷 为溶剂， 反应 7.0h， 生成 (3aR^*,4S^*,7S^*,7aR^*)-2,3,3a,4,5,6,7,7a-octahydro-4,7-methano-1H-inden-5-one
  参考文献：
  名称：

  Linearly fused vs bridged regioselection in the intramolecular 1,3-diyl trapping reaction

  摘要：

  DOI：

  10.1021/jo00296a035

文献信息

• Ethnopsychological Method and the Psychological Assessment of Mexican Americans
  作者：Guadalupe Gutierrez

  DOI：10.1177/0739986302024003001

  日期：2002.8

  This article reviews the theoretical and methodological development of ethnopsychology, which is founded on the principle that distinct cultural groups share basic common beliefs and values that differentiate them psychologically from other cultural groups. The distinctness of a cultural group is rooted in a series of historical, sociocultural experiences and perceptions of oneself and the group as a whole. The development of ethnopsychology is summarized through the contributions of Rogelio Diaz-Guerrero and his early exploration of the fundamental premises and tenets that guide ethnopsychological theory and method. The contributions of other theorists, focusing on the uniqueness of bicultural/bilingual groups such as Mexican Americans, are also summarized. The author supports the application of ethnopsychological theory and method to enhance psychologists’ understanding of bilingual/bicultural groups in the United States. Specifically, she reviews current psychological assessment methods and their ethnopsychological adaptation for Mexican Americans.

  本文回顾了民族心理学的理论和方法论发展，该学科基于这样一个原则：不同文化群体共享基本的共同信仰和价值观，这些共同点在心理上将他们与其他文化群体区分开来。文化群体的独特性根植于一系列历史、社会文化经验以及个人和整个群体对自己的认知。民族心理学的发展通过Rogelio Diaz-Guerrero的贡献进行了总结，他早期探索了指导民族心理学理论和方法的基本前提和原则。还总结了其他理论家的贡献，重点关注了墨西哥裔美国人等双文化/双语群体的独特性。作者支持将民族心理学理论和方法应用于增进心理学家对美国双文化/双语群体的理解。具体来说，她回顾了当前的心理评估方法及其在墨西哥裔美国人中的民族心理学适应性。
• What Is the True Structure of D609, a Widely Used Lipid Related Enzyme Inhibitor?
  作者：Mikako Kato、Mostafa A. S. Hammam、Tohru Taniguchi、Yoshiko Suga、Kenji Monde

  DOI：10.1021/acs.orglett.6b00025

  日期：2016.2.19

  eight possible stereoisomers, no systematic research considering its chirality has been performed. In this paper, eight possible chiral alcohols as direct precursors of D609 were synthesized, and their stereochemistries were elucidated by a vibrational circular dichroism (VCD) technique. Phosphatidylcholine-specific phospholipase C and sphingomyelin synthase inhibition assays of these isomers showed

  在过去的三十年中，D609（1）被用作脂质相关的酶抑制剂。尽管它具有八种可能的立体异构体，但尚未进行有关其手性的系统研究。本文合成了八种可能的手性醇作为D609的直接前体，并通过振动圆二色性（VCD）技术阐明了它们的立体化学。这些异构体的磷脂酰胆碱特异性磷脂酶C和鞘磷脂合酶抑制试验表明，它们的活性存在相当大的差异。
• Steric Effects on Reaction Rates - III. Application of Force-Field Calculations to Chromic Acid Oxidation of Alcohols
  作者：Paul Müller、Jacky Blanc、Dieter Lenoir

  DOI：10.1002/hlca.19820650410

  日期：1982.6.16

  The rates of oxidation with chromic acid of 15 bi- and polycyclic secondary alcohols have been measured and correlated with strain changes calculated by the MM1-program between the alcohols and the corresponding ketones. A correlation of the same quality is obtained upon representation of OH-strain by CH3-strain. The significance of the correlations with respect to the oxidation mechanism as well as

  已经测量了15种双环和多环仲醇的铬酸氧化速率，并将其与通过MM1-程序计算出的醇和相应酮之间的应变变化相关联。通过用CH 3-菌株表示OH-菌株，可获得相同质量的相关性。讨论了与氧化机理相关的意义以及力场计算对反应性问题的适用性的局限性。
• Photoinduced Nitroarenes as Versatile Anaerobic Oxidants for Accessing Carbonyl and Imine Derivatives
  作者：Joshua K. Mitchell、Waseem A. Hussain、Ajay H. Bansode、Ryan M. O’Connor、Dan E. Wise、Michael H. Choe、Marvin Parasram

  DOI：10.1021/acs.orglett.3c02292

  日期：2023.9.8

  Herein, we report a protocol for the anaerobic oxidation of alcohols, amines, aldehydes, and imines promoted by photoexcited nitroarenes. Mechanistic studies support the idea that photoexcited nitroarenes undergo double hydrogen atom transfer (HAT) steps with alcohols and amines to provide the respective ketone and imine products. In the presence of aldehydes and imines, successive HAT and oxygen atom

  在此，我们报告了光激发硝基芳烃促进醇、胺、醛和亚胺厌氧氧化的方案。机理研究支持光激发硝基芳烃与醇和胺经历双氢原子转移（HAT）步骤以提供各自的酮和亚胺产物的观点。在醛和亚胺存在的情况下，连续发生 HAT 和氧原子转移 (OAT) 事件，分别产生羧酸和酰胺。这种转变适用于连续光流设置，从而缩短了反应时间。
• Quenching of the fluorescence of 2-norbornanone and derivatives by electron-rich and electron-poor ethylenes
  作者：Nicholas J. Turro、George L. Farrington

  DOI：10.1021/ja00539a013

  日期：1980.9