(E)-ethyl 3-(4-((2-methoxyethoxy)methoxy)phenyl)acrylate | 123994-66-1

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂酸及其衍生物
• 英文名称: (E)-ethyl 3-(4-((2-methoxyethoxy)methoxy)phenyl)acrylate
• 英文别名: ethyl (E)-3-[4-(2-methoxyethoxymethoxy)phenyl]prop-2-enoate
• CAS: 123994-66-1
• 化学式: C₁₅H₂₀O₅
• 分子量: 280.321
• InChiKey: RSFCOQLAWACMND-RMKNXTFCSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  20
• 可旋转键数：
  10
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  54
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  (E)-ethyl 3-(4-((2-methoxyethoxy)methoxy)phenyl)acrylate 在 lithium hydroxide 作用下， 以 水 为溶剂， 生成 (E)-3-(4-((2-methoxyethoxy)methoxy)phenyl)acrylic acid
  参考文献：
  名称：

  Convergent total synthesis of (.+-.)-tenellin

  摘要：

  DOI：

  10.1021/jo00286a012
• 作为产物：
  描述：

  对羟基苯甲醛 在 potassium tert-butylate 、 sodium hydride 作用下， 以 四氢呋喃 为溶剂， 反应 2.0h， 生成 (E)-ethyl 3-(4-((2-methoxyethoxy)methoxy)phenyl)acrylate
  参考文献：
  名称：

  [EN] (HETERO)ARYL CYCLOPROPYLAMINE COMPOUNDS AS LSD1 INHIBITORS
  [FR] COMPOSÉS (HÉTÉRO)ARYLE CYCLOPROPYLAMINES EN TANT QU'INHIBITEURS DE LSD1

  摘要：

  本发明涉及（杂）芳基环丙胺化合物，特别是如本文所述和定义的公式I的化合物，以及它们在治疗中的用途，例如，在治疗或预防癌症、神经疾病或状况、或病毒感染中的用途。

  公开号：

  WO2013057320A1

文献信息

• Novel azole or triazole derivatives, method for preparing same and use thereof as fungicides
  申请人：Babin Didier

  公开号：US20050043540A1

  公开（公告）日：2005-02-24

  The invention concerns novel azole or triazole derivatives of formula (I), wherein X, Ar 1 , Ar 2 , Ar 3 , A, B, and R 1 are as defined herein, their preparation method and their use as fungicides.

  这项发明涉及式(I)的新型唑类或三唑类衍生物，其中X、Ar1、Ar2、Ar3、A、B和R1如本文所定义，它们的制备方法以及它们作为杀菌剂的用途。
• Stereoselective Synthesis of <b>β-</b>Methoxytyrosine Derivatives for Identification of the Absolute Configuration of Callipeltin E
  作者：Hiroyuki Konno、Sachiyo Aoyama、Kazuto Nosaka、Kenichi Akaji

  DOI：10.1055/s-2007-990848

  日期：2007.12

  Asymmetric syntheses of all diastereoisomers ofp-methoxytyrosine, an unusual amino acid contained in callipeltin A, were accomplished starting from a cinnamyl ester derivative. The stereochemistry of β-methoxytyrosine in callipeltin E was estimated to be 2R,3R by 1 H and 13 C NMR analyses of four diastereoisomeric tripeptides, each containing a β-methoxytyrosine isomer. These results obtained from the synthetic

  对甲氧基酪氨酸的所有非对映异构体的不对称合成是从肉桂酯衍生物开始的。通过四种非对映异构三肽的 1 H 和 13 C NMR 分析估计，卡利佩汀 E 中 β-甲氧基酪氨酸的立体化学为 2R、3R，每种三肽均含有 β-甲氧基酪氨酸异构体。从合成肽衍生物获得的这些结果与 D'Auria 通过降解程序获得的结果相同。
• (HETERO)ARYL CYCLOPROPYLAMINE COMPOUNDS AS LSD1 INHIBITORS
  申请人：ORYZON GENOMICS, S.A.

  公开号：US20150025054A1

  公开（公告）日：2015-01-22

  The invention relates to (hetero)aryl cyclopropylamine compounds, including particularly the compounds of formula I as described and defined herein, and their use in therapy, including, e.g., in the treatment or prevention of cancer, a neurological disease or condition, or a viral infection.

  本发明涉及（杂）芳基环丙胺化合物，特别是本文所述并定义的I式化合物，以及它们在治疗中的应用，包括例如用于治疗或预防癌症、神经疾病或病况，或病毒感染。
• Discovery of a series of selective and cell permeable beta-secretase (BACE1) inhibitors by fragment linking with the assistance of STD-NMR
  作者：Wei-Shuo Fang、De-yang Sun、Shuang Yang、Chen Cheng、Katrin Moschke、Tianqi Li、Shanshan Sun、Stefan F. Lichtenthaler、Jian Huang、Yinghong Wang

  DOI：10.1016/j.bioorg.2019.103253

  日期：2019.11

  Two beta-secreatase (BACE1) inhibitors from natural products (cinnamic acid and flavone) were linked to furnish potent, cell permeable BACE1 inhibitors with noncompetitive mode of inhibition, with the assistance of saturated transfer difference (STD)-NMR technique. Some of these conjugates also exhibited selective BACE1 inhibition over other aspartyl proteases such as BACE-2 and renin, as well as poor cytotoxicity. Taken together, conjugates 4 represent a new series of BACE inhibitors warrants further investigation for their potential in Alzheimier's disease therapy.
• Optically Anisotropic Material, Liquid Crystal Display Device and Triphenylene Compound
  申请人：Uehira Shigeki

  公开号：US20070281111A1

  公开（公告）日：2007-12-06

  An optically anisotropic material comprising at least one discotic compound having a cyclopropylcarbonyl group. The material is excellent in both the wavelength dispersion property and the refractive index anisotropy.