[Ru(η⁶-p-cymene)Cl₂(tris(dimethylamino)phosphine)] | 1071762-40-7

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: [Ru(η⁶-p-cymene)Cl₂(tris(dimethylamino)phosphine)]
• 英文别名: [Ru(η⁶-p-cymene)Cl₂P(NMe₂)₃]；Ru(η(6)-p-cymene)Cl2(P(NMe2)3)；[RuCl2(η6-p-cymene)(tris(dimethylamino)phosphine)]；[Ru(η6-p-cymene)Cl2(P(NMe2)3)]；[RuCl2(η6-cymene)(P(NMe2)3)]
• CAS: 1071762-40-7
• 化学式: C₁₆H₃₂Cl₂N₃PRu
• 分子量: 469.4
• InChiKey: GPWKDAVCOARTIG-UHFFFAOYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  4.92
• 重原子数：
  23
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  9.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  [Ru(η⁶-p-cymene)Cl₂(tris(dimethylamino)phosphine)] 、 水 以 水 为溶剂， 以45%的产率得到RuCl2(η6-p-methyl-isopropylbenzene)(NHMe2)
  参考文献：
  名称：

  Arene–Ruthenium(II) Complexes Containing Inexpensive Tris(dimethylamino)phosphine: Highly Efficient Catalysts for the Selective Hydration of Nitriles into Amides

  摘要：

  The catalytic hydration of nitriles into amides, in water under neutral conditions, has been studied using a series of arene-ruthenium(II) derivatives containing the commercially available and inexpensive ligand tris(dimethylamino)phosphine. Among them, best results were obtained with the complex [RuCl2(eta(6)-C6Me6){P(NMe2)(3)}], which selectively provided the desired amides in excellent yields and short times (TOF values up to 11 400 h(-1)). The process was operative with both aromatic, heteroaromatic, aliphatic, and alpha,beta-unsaturated organonitriles and showed a high functional group tolerance. The stability of [RuCl2(eta(6)-C6Me6){P(NMe2)(3)}] in water was evaluated, observing its progressive decomposition into the less-active dimethylamine nithenium(II) complex [RuCl2(eta(6)-C6Me6)(NHMe2)] by hydrolysis of the coordinated P(NMe2)(3) ligand. The X-ray crystal structure determination of the toluene complex [RuCl2(eta(6)-C6H5Me){P(NMe2)(3)}] is also included.

  DOI：

  10.1021/om2006563
• 作为产物：
  描述：

  [ruthenium(II)(η⁶-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]₂ 、 三(二甲胺基)膦 以 二氯甲烷 为溶剂， 以74%的产率得到[Ru(η⁶-p-cymene)Cl₂(tris(dimethylamino)phosphine)]
  参考文献：
  名称：

  钌[RuX2（eta（6）-cymene）（PY3）]（X = Cl，Br，Y = F，Cl，Br）和相关的PF2（NMe2）和P（NMe2）的三卤代膦化合物的合成与表征3种化合物；[RuBr2（eta（6）-cymene）（PF3）]，[RuBr2（eta（6）-cymene）（PF2 {NMe2}）]和[RuI2（eta）的多核NMR光谱和X射线单晶结构（6）-cymene）（P {NMe2} 3）]。

  摘要：

  在热庚烷中用PF3处理二聚体[RuX2（eta（6）-cymene）] 2会产生高收率的化合物[RuX2（eta（6）-cymene）（PF3）]（X = Cl，Br，I） 。二氟（二甲基氨基）膦和三（二甲基氨基）膦以相似的方式反应生成化合物[RuX2（eta（6）-cymene）（PF2 {NMe2}）]和[RuX2（eta（6）-cymene）（P {NMe2} 3）]。二聚体[RuX2（eta（6）-cymene）] 2与PCl3和PBr3的反应进行了单核产物的生产，该产物在某些情况下在钌上进行了卤素交换。适当时已获得（1）H，（13）C，（31）P和（19）F NMR光谱，以及（（1）H-（1）H）相关光谱（COSY）和（（13）所选化合物的C-（1）H）-HETCORR光谱。已使用自然局部分子轨道通过实验和计算研究了（1）J（（31）P-（19）F）在PF3和PF2（NMe2）配合物中的辅助配体（X）的性质变化。

  DOI：

  10.1021/ic800611h
• 作为试剂：
  描述：

  丙酮氰醇 在 [Ru(η⁶-p-cymene)Cl₂(tris(dimethylamino)phosphine)] 作用下， 以 水 、 丙酮 为溶剂， 反应 22.0h， 以15%的产率得到2-羟基异丁酰胺
  参考文献：
  名称：

  Cyanohydrin Hydration with [Ru(η⁶-p-cymene)Cl₂PR₃] Complexes

  摘要：

  The catalytic hydration of cyanohydrins to their corresponding alpha-hydroxyamides provides a route to industrially useful alpha-hydroxy amides, alpha-hydroxy esters, alpha-hydroxy carboxylic acids, and their acrylic derivatives. However, until now, no homogeneous nitrile hydration catalyst has been capable of complete conversion of cyanohydrins to their corresponding amides because cyanohydrins degrade to produce cyanide, which poisons the catalyst. Because the cyanohydrin degradation is an equilibrium process, it was hypothesized that a faster nitrile hydration catalyst would be capable of hydrating the cyanohydrin before degradation occurs. Secondary coordination sphere effects were used to develop a faster catalyst based on the [Ru(eta(6)-arene)Cl-2(PR3)] scaffold. A series of [Ru(eta(6)-p-cymene)Cl-2(PR3)] complexes, where R = NMe2, OMe, Et, was synthesized, and their activity toward cyanohydrin hydration was determined. The complex [Ru(eta(6)-p-cymene)Cl-2(P(NMe2)(3))] is an excellent catalyst, and the unprecedented complete conversion of a cyanohydrin to its corresponding amide using a homogeneous catalyst was achieved with glycolonitrile and lactonitrile.

  DOI：

  10.1021/om300047b

文献信息

• Mechanistic Investigations and Secondary Coordination Sphere Effects in the Hydration of Nitriles with [Ru(η⁶-arene)Cl₂PR₃] Complexes
  作者：Spring Melody M. Knapp、Tobias J. Sherbow、Robert B. Yelle、Lev N. Zakharov、J. Jerrick Juliette、David R. Tyler

  DOI：10.1021/om301079u

  日期：2013.2.11

  investigated. Ligands that are capable of acting as hydrogen bond acceptors with the entering water molecule result in faster rates and higher yields than non-hydrogen-bonding ligands. The faster rates are attributable to the H-bonding-facilitated deprotonation of the water as the oxygen of the water bonds to the coordinated nitrile. DFT calculations on the proposed H-bonding intermediates support this interpretation

  使用的[Ru（η腈至酰胺水合反应的机理6 -arene）氯2（PR 3）]配合物作为催化剂进行了研究（η 6 -arene = C 6 H ^ 6，p -cymene，C 6我6 ; R = NMe 2，OMe，OEt，Et，iPr）。实验表明，该机理涉及以下一般反应顺序：腈配体取代氯化物配体；水对分子间亲核的攻击，形成酰胺化物中间体；生成的酰胺离解。研究了次级配位球相互作用对水​​合反应速率和收率的影响。能够与进入的水分子充当氢键受体的配体比非氢键配体产生更快的速率和更高的产率。较快的速率归因于水的氧键合至配位的腈，因此水的氢键促成的去质子化。拟议的氢键中间体的DFT计算支持这种解释。大多数均相催化剂不会水合氰醇，因为氰醇溶液中存在平衡量的氰化物。氰化物会使催化剂中毒。由于其由于次级配位球效应而增加的催化反应性，因此[Ru（η6-芳烃）Cl 2（P（NMe 2）3）]催化剂可显着提高氰醇