1-(7-Chloro-quinolin-4-ylamino)-pyrrole-2,5-dione | 442520-06-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 1-(7-Chloro-quinolin-4-ylamino)-pyrrole-2,5-dione
• 英文别名: 1-[(7-Chloroquinolin-4-yl)amino]pyrrole-2,5-dione；1-[(7-chloroquinolin-4-yl)amino]pyrrole-2,5-dione
• CAS: 442520-06-1
• 化学式: C₁₃H₈ClN₃O₂
• 分子量: 273.678
• InChiKey: UUXPDGZSXNEHSR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  62.3
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  异戊硫醇 、 1-(7-Chloro-quinolin-4-ylamino)-pyrrole-2,5-dione 在 aluminum oxide 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 生成
  参考文献：
  名称：

  An alumina-catalyzed Michael addition of mercaptans to N -anilinomaleimides and its application to the solution-phase parallel synthesis of libraries

  摘要：

  A novel strategy for the synthesis of 3-sulfanylsubstituted 1-(arylamino)-pyrrolidine-2.5-dione derivatives via the alumina-catalyzed Michael addition of mercaptans to N-anilinomaleimides is described. The utilization of alumina in the synthesis offers important advantages such as good yields, convenience and mild conditions. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(01)02401-7
• 作为产物：
  描述：

  马来酸酐 、 7-氯-4-肼基喹啉 在 氯化亚砜 作用下， 以 四氢呋喃 为溶剂， 反应 3.0h， 以98%的产率得到1-(7-Chloro-quinolin-4-ylamino)-pyrrole-2,5-dione
  参考文献：
  名称：

  An alumina-catalyzed Michael addition of mercaptans to N -anilinomaleimides and its application to the solution-phase parallel synthesis of libraries

  摘要：

  A novel strategy for the synthesis of 3-sulfanylsubstituted 1-(arylamino)-pyrrolidine-2.5-dione derivatives via the alumina-catalyzed Michael addition of mercaptans to N-anilinomaleimides is described. The utilization of alumina in the synthesis offers important advantages such as good yields, convenience and mild conditions. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(01)02401-7

文献信息

• An alumina-catalyzed Michael addition of mercaptans to N -anilinomaleimides and its application to the solution-phase parallel synthesis of libraries
  作者：Soan Cheng、Daniel D Comer

  DOI：10.1016/s0040-4039(01)02401-7

  日期：2002.2

  A novel strategy for the synthesis of 3-sulfanylsubstituted 1-(arylamino)-pyrrolidine-2.5-dione derivatives via the alumina-catalyzed Michael addition of mercaptans to N-anilinomaleimides is described. The utilization of alumina in the synthesis offers important advantages such as good yields, convenience and mild conditions. (C) 2002 Elsevier Science Ltd. All rights reserved.