1-<(1,1-dimethyl-2-propenyl)oxy>hexadecane | 97150-09-9

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-<(1,1-dimethyl-2-propenyl)oxy>hexadecane
• 英文别名: 1-[(1,1-dimethyl-2-propenyl)oxy]hexadecane；1-(2-methylbut-3-en-2-yloxy)hexadecane
• CAS: 97150-09-9
• 化学式: C₂₁H₄₂O
• 分子量: 310.564
• InChiKey: QUPSWXKZRCMZMZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  9.1
• 重原子数：
  22
• 可旋转键数：
  17
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  1-<(1,1-dimethyl-2-propenyl)oxy>hexadecane 在 氢氧化钾 、 间氯过氧苯甲酸 作用下， 以 二氯甲烷 、 水 、 二甲基亚砜 为溶剂， 反应 8.0h， 生成
  参考文献：
  名称：

  Analogs of platelet activating factor (PAF). 2. Some modifications of the glycerine backbone

  摘要：

  Racemic analogues of platelet activating factor (PAF) that contain a methylene group between the C2 and C3 carbon atoms (39) or between the C1 and C2 carbon atoms (40) have been synthesized. These compounds show reduced platelet aggregation and hypotensive activity as measured against racemic C16 PAF. Compounds in which the C1 carbon atom of PAF is substituted with one or two methyl groups (41 and 42, respectively) or the C3 carbon is substituted with a single methyl group (43) have been synthesized. Platelet aggregation and hypotensive responses produced by these compounds are significantly less than those obtained with racemic C16 PAF. None of the above compounds exhibit a separation of the platelet aggregation and hypotensive activities.

  DOI：

  10.1021/jm00147a010
• 作为产物：
  描述：

  2-甲基-3-丁烯-2-醇 、 对甲苯磺酸十六烷基酯 在 sodium hydride 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 以75.6 g的产率得到1-<(1,1-dimethyl-2-propenyl)oxy>hexadecane
  参考文献：
  名称：

  Analogs of platelet activating factor (PAF). 2. Some modifications of the glycerine backbone

  摘要：

  Racemic analogues of platelet activating factor (PAF) that contain a methylene group between the C2 and C3 carbon atoms (39) or between the C1 and C2 carbon atoms (40) have been synthesized. These compounds show reduced platelet aggregation and hypotensive activity as measured against racemic C16 PAF. Compounds in which the C1 carbon atom of PAF is substituted with one or two methyl groups (41 and 42, respectively) or the C3 carbon is substituted with a single methyl group (43) have been synthesized. Platelet aggregation and hypotensive responses produced by these compounds are significantly less than those obtained with racemic C16 PAF. None of the above compounds exhibit a separation of the platelet aggregation and hypotensive activities.

  DOI：

  10.1021/jm00147a010

文献信息

• Gold(<scp>i</scp>)-catalysed direct allylic etherification of unactivated alcohols
  作者：Paul C. Young、Nina A. Schopf、Ai-Lan Lee

  DOI：10.1039/c2cc36760b

  日期：——

  Direct allylic etherification of unactivated alcohols occurs regio- and stereoselectively under mild, gold(I)-catalysed conditions.

  未活化的醇的直接烯丙基醚化在温和的金（I）催化条件下发生区域选择性和立体选择性。
• Antihypertensive phosphate derivatives
  申请人：American Cyanamid Company

  公开号：US04827011A1

  公开（公告）日：1989-05-02

  Antihypertensive phosphate derivatives having the following formula are described: ##STR1## wherein X is a C.sub.1 -C.sub.24 branched or straight chain alkyl group; R is selected from the group consisting of hydrogen and C.sub.1 -C.sub.4 alkyl, with the proviso that at least one R group is not hydrogen; T is selected from the group consisting of hydrogen and ##STR2## wherein R.sub.1 is selected from the group consisting of hydrogen, C.sub.1 -C.sub.4 branched or straight chain alkyl, C.sub.1 -C.sub.4 branched or straight chain alkoxy and C.sub.1 -C.sub.4 branched or straight chain alkylamino; Q is a bivalent radical selected from the group consisting of --(CH.sub.2).sub.p -- and --(CHR.sup.1).sub.p --, wherein p is an integer from 2 to 12 and the moiety --(CHR.sup.1).sub.p -- represents an alkylene chain which is substituted by one or more C.sub.1 -C.sub.10 alkyl groups or phenyl groups; Z is selected from the group consisting of ##STR3## wherein R.sub.2 may be chain alkyl and q is an integer from 4 to 7; in either the racemic or in the optically active form.

  描述具有以下公式的降压磷酸酯衍生物：其中X是C.sub.1-C.sub.24支链或直链烷基基团；R选择自氢和C.sub.1-C.sub.4烷基的群，但至少一个R基团不是氢；T选择自氢和##STR2##其中R.sub.1选择自氢、C.sub.1-C.sub.4支链或直链烷基、C.sub.1-C.sub.4支链或直链烷氧基和C.sub.1-C.sub.4支链或直链烷基氨基；Q是选择自--(CH.sub.2).sub.p--和--(CHR.sup.1).sub.p--的二价基团，其中p是从2到12的整数，而基团--(CHR.sup.1).sub.p--表示一个被一个或多个C.sub.1-C.sub.10烷基基团或苯基取代的烷基链；Z选择自##STR3##其中R.sub.2可能是链烷基，q是从4到7的整数；可以是消旋的或者是光学活性形式。
• US4827011A
  申请人：——

  公开号：US4827011A

  公开（公告）日：1989-05-02
• Analogs of platelet activating factor (PAF). 2. Some modifications of the glycerine backbone
  作者：A. Wissner、R. E. Schaub、P. E. Sum、C. A. Kohler、B. M. Goldstein

  DOI：10.1021/jm00147a010

  日期：1985.9

  Racemic analogues of platelet activating factor (PAF) that contain a methylene group between the C2 and C3 carbon atoms (39) or between the C1 and C2 carbon atoms (40) have been synthesized. These compounds show reduced platelet aggregation and hypotensive activity as measured against racemic C16 PAF. Compounds in which the C1 carbon atom of PAF is substituted with one or two methyl groups (41 and 42, respectively) or the C3 carbon is substituted with a single methyl group (43) have been synthesized. Platelet aggregation and hypotensive responses produced by these compounds are significantly less than those obtained with racemic C16 PAF. None of the above compounds exhibit a separation of the platelet aggregation and hypotensive activities.