5-Methyl-3-oxa-4-azatricyclo[5.2.1.02,6]dec-4-ene | 83670-87-5

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: 5-Methyl-3-oxa-4-azatricyclo[5.2.1.02,6]dec-4-ene
• CAS: 83670-87-5
• 化学式: C₉H₁₃NO
• 分子量: 151.208
• InChiKey: MOGAHUMTFBOGMZ-UHFFFAOYSA-N

物化性质

• 沸点：
  45 °C(Press: 0.6 Torr)
• 密度：
  1.48±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  11
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.89
• 拓扑面积：
  21.6
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  5-Methyl-3-oxa-4-azatricyclo[5.2.1.02,6]dec-4-ene 在 三氯化铝 、 W-2 Raney nickel 氢气 作用下， 以 甲醇 、 水 为溶剂， 以97%的产率得到1-((1R,2S,3R,4S)-3-Hydroxy-bicyclo[2.2.1]hept-2-yl)-ethanone
  参考文献：
  名称：

  异恶唑啉向β-羟基酮的转化方法

  摘要：

  已经开发出两种方法以立体特异性方式将异恶唑啉转化为β-羟基酮。

  DOI：

  10.1016/s0040-4039(00)88575-5
• 作为产物：
  描述：

  降冰片烯 、 O-(Trimethylsilyl)acetohydroxamoyl chloride 在 potassium fluoride 作用下， 以 乙腈 为溶剂， 以71%的产率得到5-Methyl-3-oxa-4-azatricyclo[5.2.1.02,6]dec-4-ene
  参考文献：
  名称：

  O-Trimethylsilyl hydroxamoyl chlorides as nitrile oxide precursors

  摘要：

  DOI：

  10.1021/jo00164a035

文献信息

• Pathways in the reactions of nitronate ions with sulphonyl halides
  作者：Paul E. Pigou、Charles J. M. Stirling

  DOI：10.1039/p29880000725

  日期：——

  Primary and tertiary nitronate ions and sulphonyl bromides and iodides rapidly equilibrate with the nitrohalides and sulphinate ion. Products are determined by solvent and by the occurrence of cross-equilibrium reactions, some of which have single-electron-transfer mechanisms. The reaction of arene-sulphinate and -thiolate ions with 1,2-dibromo-2-nitro-1-phenylethane gave E-β-nitrostyrene by Z-philic

  伯硝酸盐和叔硝酸盐离子和磺酰溴和碘化物与硝基卤化物和亚磺酸盐离子快速平衡。产物取决于溶剂和交叉平衡反应的发生，其中一些反应具有单电子转移机理。在两种情况下，芳烃-硫酸盐和-硫醇盐离子与1,2-二溴-2-硝基-1-苯基乙烷的反应均通过Z-亲电消除得到E -β-硝基苯乙烯，但亲脂性也得到更碱性的硫醇盐离子消除，2-溴-2-硝基-1-苯基乙烯。
• SYDNONE DERIVATIVES FOR CONJUGATION OF COMPOUNDS OF INTEREST
  申请人：UNIVERSITE DE STRASBOURG

  公开号：US20170081300A1

  公开（公告）日：2017-03-23

  The present invention relates to a process for the preparation of a first compound of interest C1 functionalized with a sydnone compound and to the corresponding functionalized C1 compound of interest. The present invention also relates to a process for the preparation of a conjugate of two compounds of interest C1 and C2 implying a sydnone compound and to the obtained conjugate. The present invention also relates to a process for preparing a compound of interest C2 comprising a strained alkyne moiety functionalized with a sydnone and to the corresponding functionalized compound of interest C2. It also relates to novel sydnone compounds substituted in position 4, which may be used in the above processes.

  本发明涉及一种用于制备与sydnone化合物功能化的感兴趣化合物C1的过程，以及所述功能化的感兴趣化合物C1。本发明还涉及一种制备涉及sydnone化合物的两种感兴趣化合物C1和C2的共轭物的过程，以及所获得的共轭物。本发明还涉及一种制备涉及带有sydnone功能化的受紧张炔基团的感兴趣化合物C2的过程，以及所述功能化的感兴趣化合物C2。此外，本发明还涉及在4位取代的新型sydnone化合物，可用于上述过程中。
• 4,5-Dihydroisoxazoles by Copper(II)-Catalysed Condensation of Primary Nitroalkanes with Dipolarophiles
  作者：Francesco De Sarlo、Fabrizio Machetti、Luca Cecchi

  DOI：10.1055/s-2007-986629

  日期：2007.9

  Primary aliphatic nitro compounds condense with substituted alkenes to give 4,5-dihydroisoxazoles under copper(II) acetate catalysis in the presence of tertiary amines. Apparently nitrile ­oxides are not intermediates, as no furoxans are detected in these ­reactions.

  初级脂肪醇硝基化合物在铜(II)醋酸盐催化下与取代烯烃缩合生成4,5-二氢异噁唑，反应中存在第三胺。显然，腈氧化物并不是中间体，因为在这些反应中未检测到呋喃氧化物。
• Iminosydnone derivatives for conjugation and release of compounds of interest
  申请人：L'Universite de Strasbourg

  公开号：EP2957559A1

  公开（公告）日：2015-12-23

  The present invention relates to the use of iminosydnone compounds in processes for the preparation of conjugates of two compounds of interest. The invention further relates to the use of said iminosydnone compounds in a process for releasing a third compound of interest. The invention finally relates to said new iminosydnone compounds.

  本发明涉及使用亚胺硝基化合物在制备两种感兴趣化合物的结合物的过程中的应用。本发明还涉及使用上述亚胺硝基化合物在释放第三种感兴趣化合物的过程中的应用。最后，本发明涉及这些新的亚胺硝基化合物。
• Sydnone derivatives for conjugation of compounds of interest
  申请人：Université de Strasbourg

  公开号：EP2944325A1

  公开（公告）日：2015-11-18

  The present invention relates to sydnone compounds substituted in position 4, to a process for the preparation of a first compound of interest C1 functionalized with a sydnone compound of the invention and to the corresponding functionalized C1 compound of interest. The present invention also relates to a process for the preparation of a conjugate of two compounds of interest C1 and C2 implying a sydnone compound according to the invention, and to the obtained conjugate. The present invention also relates to a process for preparing a compound of interest C2 comprising a strained alkyne moiety functionalized with a sydnone according to the invention and to the corresponding functionalized compound of interest C2.

  本发明涉及在第 4 位被取代的茚酮化合物，涉及用本发明的茚酮化合物官能化的第 一种相关化合物 C1 的制备工艺，以及相应的官能化的相关 C1 化合物。本发明还涉及一种根据本发明制备含有昔多酮化合物的两种相关化合物 C1 和 C2 的共轭物的工艺，以及所获得的共轭物。本发明还涉及一种根据本发明制备包含与涕酮官能化的受约束炔基的相关化合物 C2 的工艺，以及相应的官能化的相关化合物 C2。