2-(2-benzyloxy-4-isopropylphenyl)ethylamine | 409359-19-9

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: 2-(2-benzyloxy-4-isopropylphenyl)ethylamine
• 英文别名: 2-(2-phenylmethoxy-4-propan-2-ylphenyl)ethanamine
• CAS: 409359-19-9
• 化学式: C₁₈H₂₃NO
• 分子量: 269.387
• InChiKey: IZJXKLZIMGPVEZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  20
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  35.2
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-(2-benzyloxy-4-isopropylphenyl)ethylamine 、 二碳酸二叔丁酯 在 silica gel 、 ethyl acetate n-hexane 作用下， 以 四氢呋喃 为溶剂， 反应 12.0h， 以to give 12.00 g of tert-butyl N-[2-(2-benzyloxy-4-isopropyl-phenyl)ethyl]carbamate的产率得到tert-Butyl N-[2-(2-benzyloxy-4-isopropylphenyl)ethyl]-carbamate
  参考文献：
  名称：

  5-amidino-2-hydroxybenzenesulfonamide derivatives, pharmaceutical compositions containing the same and intermediates for their preparation

  摘要：

  本发明涉及一种5-酰胺基-2-羟基苯磺酰胺衍生物，其由下式表示： 其中，R1是氢原子或可选取代的较低烷基基团；R2是二（较低烷基）氨基基团、较低烷基基团、环烷基基团、可选取代的芳基基团、可选取代的杂环烷基基团或可选取代的芳香族杂环基团；T是氧原子、硫原子、磺酰基等；Q是氢原子或可选取代的较低烷基基团；Z是氢原子、羟基等，或其药学上可接受的盐，该化合物具有强效和选择性的激活血凝因子X抑制活性，并可用作预防或治疗与激活血凝因子X相关的疾病的药物，以及包含该化合物的制药组合物、其制药用途和中间体。

  公开号：

  US07589126B2
• 作为产物：
  描述：

  2-benzyloxy-4-isopropyl-1-(2-nitrovinyl)benzene 在 sodium hydroxide 作用下， 以 乙醚 、 水 为溶剂， 生成 2-(2-benzyloxy-4-isopropylphenyl)ethylamine
  参考文献：
  名称：

  5-AMIDINO-2-HYDROXYBENZENESULFONAMIDE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME AND INTERMEDIATES FOR THEIR PREPARATION

  摘要：

  公开号：

  EP1331221B1

文献信息

• 5-Amidino-2-hydroxybenzenesulfonamide derivatives, pharmaceutical compositions containing the same and intermediates for their preparation
  申请人：Okazaki Kosuke

  公开号：US20060116361A1

  公开（公告）日：2006-06-01

  The present invention relates to a 5-amidino-2-hydroxybenzenesulfonamide derivative represented by the general formula: wherein R 1 is a hydrogen atom or an optionally substituted lower alkyl group; R 2 is a di(lower alkyl)amino group, a lower alkyl group, a cycloalkyl group, an optionally substituted aryl group, an optionally substituted heterocycloalkyl group, or an optionally substituted aromatic heterocyclic group; T is an oxygen atom, a sulfur atom, a sulfonyl group etc.; Q is a hydrogen atom or an optionally substituted lower alkyl group; and Z is a hydrogen atom, a hydroxy group etc., or a pharmaceutically acceptable salt thereof, which exert a potent and selective activated blood coagulation factor X inhibitory activity and is useful as an agent for the prevention or treatment of a disease occurred associating an activated blood coagulation factor X, a pharmaceutical composition comprising the same, a pharmaceutical use thereof and an intermediate thereof.

  本发明涉及一种由通式表示的5-酰胺基-2-羟基苯磺酰胺衍生物：其中，R1是氢原子或可选择取代的较低烷基基团；R2是二（较低烷基）氨基基团、较低烷基基团、环烷基团、可选择取代的芳基基团、可选择取代的杂环烷基基团或可选择取代的芳香族杂环基团；T是氧原子、硫原子、磺酰基等；Q是氢原子或可选择取代的较低烷基基团；Z是氢原子、羟基等，或其药学上可接受的盐，具有强效和选择性的活化血凝因子X抑制活性，可用作预防或治疗与活化血凝因子X相关的疾病的药物，包括该药物的制剂、药物用途和中间体。
• Preventive or therapeutic agent for kidney disease
  申请人：Koizumi Takashi

  公开号：US20050107354A1

  公开（公告）日：2005-05-19

  The present invention relates to an agent for the prevention or treatment of a renal disease comprising as an active ingredient a 5-amidino-2-hydroxybenzenesulfonamide derivative represented by the general formula: wherein R 1 is a hydrogen atom or an optionally substituted alkyl group; R 2 is a dialkylamino group, an alkyl group, a cycloalkyl group, an optionally substituted aryl group etc.; T is an oxygen atom, a sulfur atom etc.; Q is a hydrogen atom or an optionally substituted alkyl group; and Z is a hydrogen atom, a hydroxy group etc., or a pharmaceutically acceptable salt thereof which has an inhibitory effect on mesangial cell proliferation and a decreasing effect on protein excretion in urine, and are useful for preventing or treating of various renal diseases such as IgA nephropathy, diabetic nephropathy, nephritic syndrome and the like.

  本发明涉及一种用于预防或治疗肾脏疾病的药剂，其包含作为活性成分的5-酰胺基-2-羟基苯磺酰胺衍生物，其表示为通式： 其中，R1是氢原子或可选取代的烷基基团；R2是二烷基氨基基团、烷基基团、环烷基团、可选取代的芳基基团等；T是氧原子、硫原子等；Q是氢原子或可选取代的烷基基团；Z是氢原子、羟基等，或其药学上可接受的盐，具有对系膜细胞增殖的抑制作用和对尿蛋白排泄的降低作用，适用于预防或治疗各种肾脏疾病，如IgA肾病、糖尿病肾病、肾炎综合症等。
• Agents for the prevention or treatment of renal diseases
  申请人：Kissei Pharmaceutical Co., Ltd.

  公开号：US07563822B2

  公开（公告）日：2009-07-21

  The present invention relates to an agent for the prevention or treatment of a renal disease comprising as an active ingredient a 5-amidino-2- hydroxybenzenesulfonamide derivative represented by the general formula: wherein R1 is a hydrogen atom or an optionally substituted alkyl group; R2 is a dialkylamino group, an alkyl group, a cycloalkyl group, an optionally substituted aryl group etc.; T is an oxygen atom, a sulfur atom etc.; Q is a hydrogen atom or an optionally substituted alkyl group; and Z is a hydrogen atom, a hydroxy group etc., or a pharmaceutically acceptable salt thereof which has an inhibitory effect on mesangial cell proliferation and a decreasing effect on protein excretion in urine, and are useful for preventing or treating of various renal diseases such as IgA nephropathy, diabetic nephropathy, nephritic syndrome and the like.

  本发明涉及一种用于预防或治疗肾脏疾病的药剂，其包括一种5-酰胺基-2-羟基苯磺酰胺衍生物，该衍生物由下式表示：其中，R1是氢原子或可选取代的烷基；R2是二烷基氨基基团、烷基、环烷基、可选取代的芳基等；T是氧原子、硫原子等；Q是氢原子或可选取代的烷基；Z是氢原子、羟基等，或其药学上可接受的盐，该药剂具有抑制系膜细胞增殖和减少尿蛋白排泄的作用，可用于预防或治疗各种肾脏疾病，如IgA肾病、糖尿病肾病、肾炎综合征等。
• EP1491187
  申请人：——

  公开号：——

  公开（公告）日：——
• US7208524B2
  申请人：——

  公开号：US7208524B2

  公开（公告）日：2007-04-24