4-amino-3-acetylenetrimethylsililisoquinoline | 271784-16-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 4-amino-3-acetylenetrimethylsililisoquinoline
• 英文别名: 4-amino-3-trimethylsilylethynylisoquinoline；3-(2-Trimethylsilylethynyl)isoquinolin-4-amine
• CAS: 271784-16-8
• 化学式: C₁₄H₁₆N₂Si
• 分子量: 240.38
• InChiKey: OGPMIKANGCHHEV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.05
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  38.9
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4-amino-3-acetylenetrimethylsililisoquinoline 在 sodium amide 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 16.0h， 以78%的产率得到1H-pyrrolo[3,2-c]isoquinoline
  参考文献：
  名称：

  Efficient Asymmetric Synthesis of Tryptophan Analogues Having Useful Photophysical Properties

  摘要：

  Two new fluorescent probes of protein structure and dynamics have been prepared by concise asymmetric syntheses using the Schollkopf chiral auxiliary. The site-specific incorporation of one probe into dihydrofolate reductase is reported. The utility of these tryptophan derivatives lies in their absorption and emission maxima which differ from those of tryptophan, as well as in their large Stokes shifts and high molar absorptivities.

  DOI：

  10.1021/ol403429e
• 作为产物：
  描述：

  4-溴异喹啉 在 bis-triphenylphosphine-palladium(II) chloride 、 ammonium hydroxide 、 copper(l) iodide 、 碘 、 铜 、 silver sulfate 、 三乙胺 、 copper(l) chloride 作用下， 以 四氢呋喃 、 乙醇 为溶剂， 反应 48.0h， 生成 4-amino-3-acetylenetrimethylsililisoquinoline
  参考文献：
  名称：

  Efficient Asymmetric Synthesis of Tryptophan Analogues Having Useful Photophysical Properties

  摘要：

  Two new fluorescent probes of protein structure and dynamics have been prepared by concise asymmetric syntheses using the Schollkopf chiral auxiliary. The site-specific incorporation of one probe into dihydrofolate reductase is reported. The utility of these tryptophan derivatives lies in their absorption and emission maxima which differ from those of tryptophan, as well as in their large Stokes shifts and high molar absorptivities.

  DOI：

  10.1021/ol403429e

文献信息

• Briere, Jean-Francois; Dupas, Georges; Queguiner, Guy, Heterocycles, 2000, vol. 52, # 3, p. 1371 - 1383
  作者：Briere, Jean-Francois、Dupas, Georges、Queguiner, Guy、Bourguignon, Jean

  DOI：——

  日期：——
• Efficient Asymmetric Synthesis of Tryptophan Analogues Having Useful Photophysical Properties
  作者：Poulami Talukder、Shengxi Chen、Pablo M. Arce、Sidney M. Hecht

  DOI：10.1021/ol403429e

  日期：2014.1.17

  Two new fluorescent probes of protein structure and dynamics have been prepared by concise asymmetric syntheses using the Schollkopf chiral auxiliary. The site-specific incorporation of one probe into dihydrofolate reductase is reported. The utility of these tryptophan derivatives lies in their absorption and emission maxima which differ from those of tryptophan, as well as in their large Stokes shifts and high molar absorptivities.