4-(diazomethylene)carbonyl-2-phenoxy-6-methoxyquinoline | 359784-28-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 4-(diazomethylene)carbonyl-2-phenoxy-6-methoxyquinoline
• 英文别名: 2-Diazonio-1-(6-methoxy-2-phenoxyquinolin-4-yl)ethen-1-olate；2-diazo-1-(6-methoxy-2-phenoxyquinolin-4-yl)ethanone
• CAS: 359784-28-4
• 化学式: C₁₈H₁₃N₃O₃
• 分子量: 319.32
• InChiKey: RKLZUDIEUXWLCY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  24
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  50.4
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  4-(diazomethylene)carbonyl-2-phenoxy-6-methoxyquinoline 在 氨 、 silver nitrate 作用下， 反应 2.0h， 以76.4%的产率得到2-(6-Methoxy-2-phenoxy-quinolin-4-yl)-acetamide
  参考文献：
  名称：

  Quinoline-4-acetamides as sPLA2 inhibitors

  摘要：

  Quinoline-4-acetamides were designed as potential phospholipase Al inhibitors by structural based method and synthesized. The chemical structures of the obtained compounds were confirmed by elemental analyses, H-1 NMR and MS. Preliminary bioassay study shows that quinoline-4-acetamides display certain inhibition to sPLA(2). (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(01)00229-3
• 作为产物：
  描述：

  乙酰基乙酰对甲氧基苯胺 在 氢氧化钾 、 sodium hydroxide 、 sodium periodate 、 四氧化锇 、 草酰氯 、 硫酸 、 silver nitrate 、 zinc(II) chloride 、 三氯氧磷 作用下， 以 乙醚 为溶剂， 反应 72.5h， 生成 4-(diazomethylene)carbonyl-2-phenoxy-6-methoxyquinoline
  参考文献：
  名称：

  Quinoline-4-acetamides as sPLA2 inhibitors

  摘要：

  Quinoline-4-acetamides were designed as potential phospholipase Al inhibitors by structural based method and synthesized. The chemical structures of the obtained compounds were confirmed by elemental analyses, H-1 NMR and MS. Preliminary bioassay study shows that quinoline-4-acetamides display certain inhibition to sPLA(2). (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(01)00229-3

文献信息

• Quinoline-4-acetamides as sPLA2 inhibitors
  作者：Ying Liu、Yabing Feng、Renxiao Wang、Ying Gao、Luhua Lai

  DOI：10.1016/s0960-894x(01)00229-3

  日期：2001.7

  Quinoline-4-acetamides were designed as potential phospholipase Al inhibitors by structural based method and synthesized. The chemical structures of the obtained compounds were confirmed by elemental analyses, H-1 NMR and MS. Preliminary bioassay study shows that quinoline-4-acetamides display certain inhibition to sPLA(2). (C) 2001 Elsevier Science Ltd. All rights reserved.