Bicyclo[2.2.1]hept-2-yl-hydrazine

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: Bicyclo[2.2.1]hept-2-yl-hydrazine
• 英文别名: Bicyclo[2.2.1]heptan-2-ylhydrazine；2-bicyclo[2.2.1]heptanylhydrazine
• 化学式: C₇H₁₄N₂
• 分子量: 126.202
• InChiKey: LVNOTBRXUIUZQB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  9
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  38
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  Bicyclo[2.2.1]hept-2-yl-hydrazine 、 在 吡啶 、 sodium hydroxide 、 草酸 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 生成 5-Benzyl-2-(2-bicyclo[2.2.1]heptanyl)pyrazolo[4,3-c]quinolin-3-one
  参考文献：
  名称：

  Synthesis and biological evaluation of 2,5-dihydropyrazolo[4,3-c]quinolin-3-ones, a novel series of PDE 4 inhibitors with low emetic potential and antiasthmatic properties

  摘要：

  A novel series of 2,5-dihydropyrazolo[4,3-c]quinolin-3-one has been prepared. These compounds showed good PDE 4 inhibitory activity and weak affinity for rolipram's binding site. They also exhibited a good anti-inflammatory profile without emetic side effects. (C) 2000 Published by Elsevier Science Ltd.

  DOI：

  10.1016/s0960-894x(00)00548-5

文献信息

• AMINE-CONTAINING LIPIDOIDS AND USES THEREOF
  申请人：Massachusetts Institute of Technology

  公开号：US20140161830A1

  公开（公告）日：2014-06-12

  Provided herein are lipidoids that may be prepared from the conjugate addition of alkylamines to acrylates. In some embodiments, provided lipidoids are biodegradable and may be used in a variety of drug delivery systems. Given the amino moiety of the lipidoids, they are well-suited for the delivery of polynucleotides, in addition to other agents. Nanoparticles containing the inventive lipidoids and polynucleotides have been prepared and have been shown to be effective in delivering siRNA.