Vitamin k1(20),heptafluorobutyric deriv.

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: Vitamin k1(20),heptafluorobutyric deriv.
• 英文别名: [2,5-dimethyl-2-(4,8,12-trimethyltridecyl)-3,4-dihydrobenzo[h]chromen-6-yl] 2,2,3,3,4,4,4-heptafluorobutanoate
• 化学式: C₃₅H₄₇F₇O₃
• 分子量: 648.745
• InChiKey: UQUBJCQTVUKVNB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  13.8
• 重原子数：
  45
• 可旋转键数：
  16
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.69
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  10

反应信息

• 作为产物：
  描述：

  维生素K-1 、 七氟丁酸酐 在 七氟丁酸 、 锌 作用下， 以 正己烷 为溶剂， 反应 1.0h， 生成 Vitamin k1(20),heptafluorobutyric deriv.
  参考文献：
  名称：

  Method for the Determination of Vitamin K1(20)in Human Plasma by Stable Isotope Dilution/Gas Chromatography/Mass Spectrometry

  摘要：

  A method for the quantitative determination of vitamin K-1(20) (VK), an essential cofactor in the carboxylation of clotting factors, is presented. The assay is based on gas chromatography/electron impact mass/spectrometry. The preparation of deuterium-labelled vitamin K-1(20) for use as an internal standard is described. The method involves extraction of Vg from human plasma and its derivatization to the heptafluorobutyryl ester after reduction of one carbonyl group with zinc. The detection limit was found to be 1.0 pg and the limit of quantitation 2.0 pg ml(-1) plasma. This permits the measurement of vitamin K-1(20) even in small quantities of plasma, which is highly desirable in investigations dealing with clotting abnormalities in neonates and infants.

  DOI：

  10.1002/(sici)1096-9888(199606)31:6<655::aid-jms339>3.0.co;2-t

文献信息

• Method for the Determination of Vitamin K1(20)in Human Plasma by Stable Isotope Dilution/Gas Chromatography/Mass Spectrometry
  作者：G. Fauler、H. J. Leis、J. Schalamon、W. Muntean、H. Gleispach

  DOI：10.1002/(sici)1096-9888(199606)31:6<655::aid-jms339>3.0.co;2-t

  日期：1996.6

  A method for the quantitative determination of vitamin K-1(20) (VK), an essential cofactor in the carboxylation of clotting factors, is presented. The assay is based on gas chromatography/electron impact mass/spectrometry. The preparation of deuterium-labelled vitamin K-1(20) for use as an internal standard is described. The method involves extraction of Vg from human plasma and its derivatization to the heptafluorobutyryl ester after reduction of one carbonyl group with zinc. The detection limit was found to be 1.0 pg and the limit of quantitation 2.0 pg ml(-1) plasma. This permits the measurement of vitamin K-1(20) even in small quantities of plasma, which is highly desirable in investigations dealing with clotting abnormalities in neonates and infants.