5-叠氮基-5-脱氧胸腺嘧啶脱氧核苷 | 19316-85-9
分子结构分类
中文名称
5-叠氮基-5-脱氧胸腺嘧啶脱氧核苷
中文别名
5'-叠氮基-5'-脱氧胸苷
英文名称
5'-azido-5'-deoxythymidine
英文别名
5’-azido-5’-deoxythymidine；5′-azido-5′-deoxythymidine；Thymidine, 5'-azido-5'-deoxy-；1-[(2R,4S,5R)-5-(azidomethyl)-4-hydroxyoxolan-2-yl]-5-methylpyrimidine-2,4-dione
CAS
19316-85-9
化学式
C10H13N5O4
mdl
——
分子量
267.244
InChiKey
GKEHVJFBPNPCKI-XLPZGREQSA-N
BEILSTEIN
——
EINECS
——
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物化性质
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计算性质
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ADMET
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安全信息
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SDS
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制备方法与用途
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上下游信息
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文献信息
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表征谱图
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同类化合物
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相关功能分类
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相关结构分类
物化性质
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熔点：164-166℃
计算性质
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辛醇/水分配系数(LogP)：-0.1
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重原子数：19
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可旋转键数：3
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环数：2.0
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sp3杂化的碳原子比例：0.6
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拓扑面积：93.2
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氢给体数：2
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氢受体数：6
SDS
上下游信息
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上游原料
中文名称 英文名称 CAS号 化学式 分子量 —— 3'-O-acetyl-5'-azido-5'-deoxythymidine 27766-92-3 C12H15N5O5 309.282 beta-胸苷 thymidine 146183-25-7 C10H14N2O5 242.232 —— 5'-chloro-5'-deoxythymidine 25905-50-4 C10H13ClN2O4 260.677 —— 5′-azide-3′-O-tert-butyldimethylsilyl deoxythymidine 132101-17-8 C16H27N5O4Si 381.507 —— 1-((2R,4S,5S)-4-hydroxy-5-(iodomethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione —— C10H13IN2O4 352.129 —— ((2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1 (2H)-yl)tetrahydrofuran-2-yl)methyl methanesulfonate 29391-35-3 C11H16N2O7S 320.323 3'-O-(叔丁基二甲基硅烷基)胸苷 3'-O-(t-butyldimethylsilyl)thymidine 40733-27-5 C16H28N2O5Si 356.494 5-O-(4-甲基苯基磺酰基)胸腺嘧啶脱氧核苷 5'-O-(p-toluenesulfonyl)thymidine 7253-19-2 C17H20N2O7S 396.421 —— 5′-O-mesyl-3′-O-tert-butyldimethylsilyl deoxythymidine 171563-32-9 C17H30N2O7SSi 434.586 -
下游产品
中文名称 英文名称 CAS号 化学式 分子量 —— 1-(5'-azido-2',5'-dideoxy-β-D-threo-pentofuranosyl)thymine —— C10H13N5O4 267.244 5-氨基-5-脱氧胸腺嘧啶脱氧核苷 5'-amino-5'-deoxythymidine 25152-20-9 C10H15N3O4 241.247 —— 5'-azido-5'-deoxy-3'-O-(prop-2-yn-1-yl)thymidine 1377986-01-0 C13H15N5O4 305.293 —— 1-[5'-azido-2',5'-dideoxy-3'-O-(prop-2-yn-1-yl)-β-D-threo-pentofuranosyl]thymine 1377986-08-7 C13H15N5O4 305.293 —— 5'-formamido-5'-deoxythymidine 132101-23-6 C11H15N3O5 269.257 —— 3'-O-acetyl-5'-azido-5'-deoxythymidine 27766-92-3 C12H15N5O5 309.282 5-三氟乙酰氨基-5-脱氧胸腺嘧啶脱氧核苷 2,2,2-trifluoro-N-(((2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl)methyl)acetamide 55812-00-5 C12H14F3N3O5 337.255 —— 3'-O-acetyl-5'-amino-5'-deoxythymidine 27930-49-0 C12H17N3O5 283.284 —— ethyl 2-[(2-ethoxy-2-oxoethyl)-[[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methyl]amino]acetate 289505-75-5 C18H27N3O8 413.428 —— ethyl 3-[[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-pyrimidin-1-yl)tetrahydrofuran-2-yl]methylcarbamoylamino]propanoate 1416441-83-2 C16H24N4O7 384.389 —— 5′-azide-3′-O-tert-butyldimethylsilyl deoxythymidine 132101-17-8 C16H27N5O4Si 381.507 —— 1-benzyl-3-[[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-pyrimidin-1-yl)tetrahydrofuran-2-yl]methyl]urea 1416441-84-3 C18H22N4O5 374.396 —— 5'-amino-3'-tert-butyldimethylsilyl-5'-deoxythymidine 130128-70-0 C16H29N3O4Si 355.509 —— 1-[(2R,4S,5R)-4-hydroxy-5-[[(4-nitrophenyl)methylamino]methyl]tetrahydrofuran-2-yl]-5-methyl-pyrimidine-2,4-dione 1416441-82-1 C17H20N4O6 376.369 —— N-(5'-deoxy-thymidin-5'-yl)-N'-phenylurea 1416441-86-5 C17H20N4O5 360.37 —— N-(5'-deoxy-thymidin-5'-yl)-N'-(4-bromo-phenyl)thiourea 1416441-92-3 C17H19BrN4O4S 455.332 —— N-(5'-deoxy-thymidin-5'-yl)-N'-(4-chloro-phenyl)thiourea 1416441-90-1 C17H19ClN4O4S 410.881 —— N-(5'-deoxy-thymidin-5'-yl)-N'-(4-bromo-phenyl)urea 1416441-91-2 C17H19BrN4O5 439.266 —— 5'-azido-3'-O-trityl-5'-deoxythymidine 219652-98-9 C29H27N5O4 509.564 —— N-(5'-deoxy-thymidin-5'-yl)-N'-(4-chloro-phenyl)urea 1416441-89-8 C17H19ClN4O5 394.815 —— N-[[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-pyrimidin-1-yl)tetrahydrofuran-2-yl]methyl]naphthalene-2-carboxamide 1416441-81-0 C21H21N3O5 395.415 —— 1-(3-chlorophenyl)-3-[[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-pyrimidin-1-yl)tetrahydrofuran-2-yl]methyl]urea 1416441-88-7 C17H19ClN4O5 394.815 —— 1-[[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-pyrimidin-1-yl)tetrahydrofuran-2-yl]methyl]-3-(3-pyridyl)urea 1416441-85-4 C16H19N5O5 361.357 —— N-(5'-deoxy-thymidin-5'-yl)-N'-(4-phenylphenyl)urea 1416442-31-3 C23H24N4O5 436.467 —— N-(5'-deoxy-thymidin-5'-yl)-N'-(4-methoxyl-phenyl)urea 1416441-95-6 C18H22N4O6 390.396 —— N-(5'-deoxy-thymidin-5'-yl)-N'-(4-tert-butyl-phenyl)urea 1416441-96-7 C21H28N4O5 416.477 —— N-(5'-deoxy-thymidin-5'-yl)-N'-(2-chloro-phenyl)urea 1416441-87-6 C17H19ClN4O5 394.815 —— N-[[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-pyrimidin-1-yl)tetrahydrofuran-2-yl]methyl]naphthalene-2-sulfonamide 1416441-80-9 C20H21N3O6S 431.469 —— N-(5'-deoxy-thymidin-5'-yl)-N'-(4-nitro-phenyl)urea 1416442-01-7 C17H19N5O7 405.367 —— N-(5'-deoxy-thymidin-5'-yl)-N'-(4-piperdin-1-ylphenyl)urea 1416442-44-8 C22H29N5O5 443.503 —— 5'-amino-3'-O-trityl-5'-deoxythymidine 219653-00-6 C29H29N3O4 483.567 —— 5'-deoxy-5'-(4-nitrobenzamido)thymidine 119422-74-1 C17H18N4O7 390.353 —— N-(5'-deoxy-thymidin-5'-yl)-N'-(4-(4-methylpiperazinyl)phenyl)urea 1416442-46-0 C22H30N6O5 458.517 —— N-(5'-deoxy-thymidin-5'-yl)-N'-(3-methoxyl-phenyl)urea 1416441-94-5 C18H22N4O6 390.396 —— N-(5'-deoxy-thymidin-5'-yl)-N'-(4-tetrahydropyran-4-oxyphenyl)urea 1416442-42-6 C22H28N4O7 460.487 —— N-(5'-deoxy-thymidin-5'-yl)-N'-(4-benzyloxyphenyl)urea 1421229-72-2 C24H26N4O6 466.494 —— 5'-monomethoxytritylamino-2',5'-dideoxythymidine 118849-15-3 C30H31N3O5 513.593 —— N-(5'-deoxy-thymidin-5'-yl)-N'-(2-methoxyl-phenyl)urea 1416441-93-4 C18H22N4O6 390.396 —— N-(5'-deoxy-thymidin-5'-yl)-N'-(4-(4-methoxybenzyloxy)phenyl)urea 1416442-62-0 C25H28N4O7 496.52 —— 5'-deoxy-5'-p-nitrobenzenesulphonylaminothymidine 91067-54-8 C16H18N4O8S 426.407 —— N-(5'-deoxy-thymidin-5'-yl)-N'-(3-(phenoxymethyl)phenyl)urea 1416442-35-7 C24H26N4O6 466.494 —— N-(5'-deoxy-thymidin-5'-yl)-N'-(2-phenylphenyl)urea 1416442-29-9 C23H24N4O5 436.467 —— N-(5'-deoxy-β-D-thymidin-5'-yl)-N'-(4-chloro-3-trifluoromethylphenyl)thiourea 1352504-86-9 C18H18ClF3N4O4S 478.88 —— N-(5'-deoxy-thymidin-5'-yl)-N'-(4-(2-chlorobenzyloxy)phenyl)urea 1416442-60-8 C24H25ClN4O6 500.939 —— N-(5'-deoxy-thymidin-5'-yl)-N'-(3-trifluoromethyl-4-chlorophenyl)urea 1416441-98-9 C18H18ClF3N4O5 462.813 —— N-(5'-deoxy-thymidin-5'-yl)-N'-(2-(phenoxymethyl)phenyl)urea 1416442-38-0 C24H26N4O6 466.494 —— 5'-monomethoxytritylamino-2',5'-dideoxythymidine-3'-O-succinate 278168-49-3 C34H35N3O8 613.667 —— (2-hydroxyphenyl) N-[[(2R,3S,5R)-3-[tert-butyl(dimethyl)silyl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methyl]sulfamate 193894-18-7 C22H33N3O8SSi 527.671 —— N3-[2-(α-D-mannopyranosyloxy)ethyl]-5'-octylthioureido-2',5'-dideoxythymidine 1332574-58-9 C27H46N4O10S 618.749 —— 6,5'-Imino-5-deoxythymidine 73971-81-0 C10H13N3O4 239.231 5'-脱氧-5'-[4-苯基-(1,2,3)三唑-1-基]胸苷 5'-deoxy-5'-[4-phenyl-(1,2,3)triazol-1-yl]thymidine 1046354-49-7 C18H19N5O4 369.38 —— 5'-(4-chlorophenyl-1,2,3-triazol-1-yl)-5'-deoxy-β-D-thymidine 1352504-91-6 C18H18ClN5O4 403.825 —— 5'-azido-2,3'-anhydrothymidine 132101-27-0 C10H11N5O3 249.229 —— 5'-N-(4-methoxytrityl)-5'-amino-5'-deoxy-thymidine-3'-(2-cyanoethyl-N,N-diisopropylphosphoramidite) 120021-10-5 C39H48N5O6P 713.814 —— 2'-amino-2'-deoxyuridylyl (3'-5') 5'-amino-5'-deoxythymidine 182005-91-0 C19H27N6O11P 546.431 —— 5-methyl-1-[(5aS,7R,8aR)-5a,6,8a,9-tetrahydro-4H,7H-furo[3,2-b][1,2,3]triazolo[1,5-e][1,4]-oxazepin-7-yl]pyrimidine-2,4(1H,3H)-dione 1377986-03-2 C13H15N5O4 305.293 —— 5-methyl-1-[(5aR,7R,8aR)-5a,6,8a,9-tetrahydro-4H,7H-furo[3,2-b][1,2,3]triazolo[1,5-e][1,4]oxazepin-7-yl]pyrimidine-2,4(1H,3H)-dione 1377986-09-8 C13H15N5O4 305.293 5'-脱氧-5'-[4-(4-氟苯基)-(1,2,3)三唑-1-基]胸苷 5'-deoxy-5'-[4-(4-fluorophenyl)-(1,2,3)triazol-1-yl]thymidine 1046354-53-3 C18H18FN5O4 387.37 —— 5'-deoxy-5'-[4-(4-methoxyphenyl)-(1,2,3)triazol-1-yl]thymidine 1046354-57-7 C19H21N5O5 399.406 —— Succinic acid (2R,3S,5R)-2-({[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-methyl)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 4-nitro-phenyl ester 278168-50-6 C40H38N4O10 734.763 —— 5'-O-(4,4'-dimethoxytrityl)-3'-deoxythymidinylsulfamido-(3'(N)->5'(N))-5'-deoxythymidine 193894-21-2 C41H46N6O12S 846.915 5'-脱氧-5'-[4-(吡啶-3-基)-(1,2,3)三唑-1-基]胸苷 5'-deoxy-5'-[4-(pyridin-3-yl)-(1,2,3)triazol-1-yl]thymidine 1046354-61-3 C17H18N6O4 370.368 —— N-(5'-deoxy-thymidin-5'-yl)-N'-(4-(6-methyl-2-benzothiazolyl)phenyl)urea 1416442-48-2 C25H25N5O5S 507.57 —— 5'-deoxy-5'-{4-[(2-oxo-2H-chromen-7-yloxy)methyl]-1H-1,2,3-triazol-1-yl}thymidine —— C22H21N5O7 467.438 —— 1-[(2R,4S,5R)-5-[[4-[[(2R,3S,5R)-2-[[tert-butyl(dimethyl)silyl]oxymethyl]-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-3-yl]oxymethyl]triazol-1-yl]methyl]-4-hydroxyoxolan-2-yl]-5-methylpyrimidine-2,4-dione 1011727-49-3 C29H43N7O9Si 661.787 —— N-(2-chloroethyl)-N-[[1-[[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methyl]triazol-4-yl]methyl]-2-(5-methyl-2,4-dioxopyrimidin-1-yl)acetamide 1338733-44-0 C22H27ClN8O7 550.959 —— 4,4,5,5,6,6,7,7,8,8,9,9,10,10,11,11,11-heptadecafluoro-N-[[1-[[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methyl]triazol-4-yl]methyl]undecanamide 1215215-66-9 C24H21F17N6O5 796.441 —— 2-[(2S,3R,5R)-5-(2-amino-6-oxo-1H-purin-9-yl)-2-(hydroxymethyl)tetrahydrofuran-3-yl]-N-[[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-pyrimidin-1-yl)tetrahydrofuran-2-yl]methyl]acetamide —— C22H28N8O8 532.513 —— [(2R,3S,5R)-3-[[1-[[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methyl]triazol-4-yl]methoxy]-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methyl 4-methylbenzenesulfonate 1038442-98-6 C30H35N7O11S 701.714 —— 5'-O-(4,4'-dimethoxytrityl)-3'-deoxythymidin-3'-ylsulfamido-[3'(N)->5'(N)]-3'-O-(tert-butyldimethylsilyl)-5'-deoxythymidine 193894-17-6 C47H60N6O12SSi 961.178 —— [(2R,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-2-(hydroxymethyl)-4-[(2,2,2-trifluoroacetyl)amino]oxolan-3-yl]oxy-N-[[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methyl]phosphonamidic acid 182006-05-9 C21H26F3N6O12P 642.439 —— 5'-deoxy-5'-{4-[2-(3-oxo-3H-benzo[f]chromen-1-yl)acetamidomethyl]-1H-1,2,3-triazol-1-yl}thymidine —— C28H26N6O7 558.55 —— 1-(5'-deoxythymidin-5'-yl)-4-[methyl-(2'-deoxy-2',2'-difluorocytidin-4N-yl)]-1H-1,2,3-triazole —— C22H26F2N8O8 568.494 —— 1-(5'-deoxythymidin-5'-yl)-4-[methyloxycarbonyl-(2'-deoxy-2',2'-difluorocytidin-4N-yl)]-1H-1,2,3-triazole —— C23H26F2N8O10 612.504 —— 4-amino-5-methyl-1-[ (5aS,7R,8aR)-5a,6,8a,9-tetrahydro-4H,7H-furo[3,2-b][1,2,3]triazolo[1,5-e]-[1,4]oxazepin-7-yl]pyrimidin-2(1H)-one 1377986-05-4 C13H16N6O3 304.308 —— 4-amino-5-methyl-1-[(5aS,7R,8aR)-5a,6,8a,9-tetrahydro-4H,7H-furo[3,2-b][1,2,3]triazolo[1,5-e][1,4]oxazepin-7-yl]pyrimidin-2(1H)-one 1377986-10-1 C13H16N6O3 304.308 ——