2'，5'-二脱氧尿苷 | 35959-50-3

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 2 '，5'-二脱氧核苷
• 中文名称: 2'，5'-二脱氧尿苷
• 英文名称: 2',5'-dideoxyuridine
• 英文别名: 2',5'-Dideoxyuridin；1-[(2R,4S,5R)-4-hydroxy-5-methyloxolan-2-yl]pyrimidine-2,4-dione
• CAS: 35959-50-3
• 化学式: C₉H₁₂N₂O₄
• 分子量: 212.205
• InChiKey: FDCFKLBIAIKUKB-GKROBHDKSA-N

物化性质

• 溶解度：
  可溶于DMSO（少许）、甲醇（少许）

计算性质

• 辛醇/水分配系数(LogP)：
  -1.1
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  78.9
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  在 甲醇 、 camphor-10-sulfonic acid 、 sodium methylate 、 N,O-双(三甲基硅烷基)三氟乙酰胺 作用下， 以 乙腈 为溶剂， 反应 5.0h， 生成 2'，5'-二脱氧尿苷
  参考文献：
  名称：

  CN115850356

  摘要：

  公开号：

文献信息

• Stabilized siRNAs as transfection controls and silencing reagents
  申请人：Leake Devin

  公开号：US20070269889A1

  公开（公告）日：2007-11-22

  RNA molecules, including siRNA molecules and related control, trackability and exaequo agents with specific stability modifications are provided. These molecules are particularly advantageous as transfection control reagents. The molecules include first and second 5′ terminal sense nucleotides with 2′-O-alkyl groups and a label on the first 5′ terminal sense nucleotide, in conjunction with at least one additional 2′-O-alkyl pyrimidine modified sense nucleotide, and either: (i) at least one 2′ fluoro modified pyrimidine antisense nucleotide and a phosphorylated first 5′ terminal antisense nucleotide; or (ii) a first and second 5′ terminal antisense nucleotide with 2′-O-alkyl modifications and at least one additional 2′-O-alkyl pyrimidine modified antisense nucleotide.

  提供了包括siRNA分子和相关的控制、可追踪性和稳定性修饰的分子。这些分子作为转染控制试剂特别有优势。这些分子包括第一和第二个5'端感受核苷酸，具有2'-O-烷基基团和第一个5'端感受核苷酸上的标记，与至少一个额外的2'-O-烷基嘧啶修饰的感受核苷酸一起，以及：（i）至少一个2'-氟修饰的嘧啶反义核苷酸和一个磷酸化的第一个5'端反义核苷酸；或者（ii）第一和第二个5'端反义核苷酸具有2'-O-烷基修饰和至少一个额外的2'-O-烷基嘧啶修饰的反义核苷酸。
• STABILIZED SIRNAS AS TRANSFECTION CONTROLS AND SILENCING REAGENTS
  申请人：Leake Devin

  公开号：US20090280567A1

  公开（公告）日：2009-11-12

  RNA molecules, including siRNA molecules and related control, trackability and exaequo agents with specific stability modifications are provided. These molecules are particularly advantageous as transfection control reagents. The molecules include first and second 5′ terminal sense nucleotides with 2′-O-alkyl groups and a label on the first 5′ terminal sense nucleotide, in conjunction with at least one additional 2′-O-alkyl pyrimidine modified sense nucleotide, and either: (i) at least one 2′ fluoro modified pyrimidine antisense nucleotide and a phosphorylated first 5′ terminal antisense nucleotide; or (ii) a first and second 5′ terminal antisense nucleotide with 2′-O-alkyl modifications and at least one additional 2′-O-alkyl pyrimidine modified antisense nucleotide.

  提供了RNA分子，包括siRNA分子和相关的控制、可追踪性和具有特定稳定性修饰的exaequo剂。这些分子作为转染控制试剂特别有优势。这些分子包括第一和第二个5'端的感知核苷酸，具有2'-O-烷基基团和第一5'端的标签，以及至少一个附加的2'-O-烷基嘧啶修饰感知核苷酸，以及：(i)至少一个2'-氟修饰的嘧啶反义核苷酸和一个磷酸化的第一5'端反义核苷酸；或者(ii)第一和第二个5'端反义核苷酸具有2'-O-烷基修饰和至少一个附加的2'-O-烷基嘧啶修饰反义核苷酸。
• CYANINE DYES AND METHODS OF USE
  申请人：Peng Xinzhan

  公开号：US20070042398A1

  公开（公告）日：2007-02-22

  The present invention provides for cyanine dyes as near IR quenchers. The cyanine dyes have absorption wavelengths in the near-infrared region of about 650-900 nm and are essentially non-fluorescent. The dyes of the invention have at least one linking group. The present invention also provides substantially non-fluorescent, NIR probes. Biological assays based on these novel, substantially non-fluorescent, NIR probes are also provided.

  本发明提供了靠近红外熄灭剂的靛青染料。这些靛青染料在近红外区域具有吸收波长，约为650-900纳米，并且基本上不发光。本发明的染料具有至少一个连接基团。本发明还提供了基本上不发光的近红外探针。基于这些新型、基本上不发光的近红外探针的生物测定也提供了。
• Synthesis of Nucleosides and Deoxynucleosides via Gold(I)-Catalyzed <i>N</i>-Glycosylation of Glycosyl (<i>Z</i>)-Ynenoates
  作者：Rongkun Liu、Yan Chen、Jibin Zheng、Lvfeng Zhang、Tong Xu、Peng Xu、You Yang

  DOI：10.1021/acs.orglett.2c03964

  日期：2022.12.30

  with purines was found to be very effective for regioselective synthesis of pyranosyl N9 purine nucleosides. Based on the catalytic N-glycosylation approach, convenient synthesis of two 5′-deoxynucleosides drugs (capecitabine and galocitabine), four 2′-deoxynucleoside drugs (floxuridine, trifluridine, decitabine and cladribine), four 3′,5′-dideoxynucleoside analogues, and four 2′,5′-dideoxynucleoside

  核苷类似物广泛用作抗癌和抗病毒药物。在这里，我们开发了一种高效的金（I）催化的N-糖基化方法，用于以糖基（Z）-炔酸作为供体合成各种类型的核苷和脱氧核苷。31 个嘧啶核苷和 8 个嘌呤核苷的合成证明了N-糖基化方法的广泛范围。值得注意的是，金（I）催化的吡喃糖基（Z ）-炔酸酯与嘌呤的N-糖基化被发现对于吡喃糖基N9嘌呤核苷的区域选择性合成非常有效。基于催化N-糖基化方法，方便合成两种5'-脱氧核苷药物（卡培他滨和加西他滨）、四种2'-脱氧核苷药物（氟尿苷、三氟尿苷、地西他滨和克拉屈滨）、四种3',5'-双脱氧核苷类似物，并集体获得了4个2',5'-双脱氧核苷类似物。
• Advanced drug development and manufacturing
  申请人：Los Alamos National Security, LLC

  公开号：EP2511844A2

  公开（公告）日：2012-10-17

  There is described an apparatus for measuring protein characteristics comprising an X-ray fluorescence (XRF) spectrometer comprising a source of polychromatic X-rays, an X-ray detector, a protein, a molecule that has been exposed to and at least weakly binds to the protein, a plurality of X-ray fluorescence signal data obtained by irradiating chemical elements in the protein and molecule with the polychromatic X-rays and a security system for maintaining records for the data from the plurality of X-ray fluorescence signal measurements. There is also described an x-ray microscope for measuring a sample.

  描述了一种测量蛋白质特性的仪器，该仪器包括一个 X 射线荧光 (XRF) 光谱仪，其中包括一个多色 X 射线源、一个 X 射线探测器、一个蛋白质、一个已暴露于该蛋白质并至少与该蛋白质弱结合的分子、通过用多色 X 射线照射蛋白质和分子中的化学元素而获得的多个 X 射线荧光信号数据，以及一个用于维护多个 X 射线荧光信号测量数据记录的安全系统。此外，还介绍了一种用于测量样品的 X 射线显微镜。