6-chloro-1-ethyl-1,4-dihydro-4-oxoquinoline-3-carbohydrazide | 672948-17-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 6-chloro-1-ethyl-1,4-dihydro-4-oxoquinoline-3-carbohydrazide
• 英文别名: 6-Chloro-1-ethyl-4-oxoquinoline-3-carbohydrazide；6-chloro-1-ethyl-4-oxoquinoline-3-carbohydrazide
• CAS: 672948-17-3
• 化学式: C₁₂H₁₂ClN₃O₂
• 分子量: 265.699
• InChiKey: BTCJAIKYQBMUOS-UHFFFAOYSA-N

物化性质

• 熔点：
  224-226 °C
• 密度：
  1.384±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  75.4
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  6-chloro-1-ethyl-1,4-dihydro-4-oxoquinoline-3-carbohydrazide 、 对甲苯磺酰氯 在 吡啶 作用下， 以 二氯甲烷 、 乙酸乙酯 为溶剂， 反应 4.0h， 生成 6-chloro-1-ethyl-4-oxo-1,4-dihydro-3-[1-oxo-2-hydrazino-3-{p-toluenesulfon}]quinoline
  参考文献：
  名称：

  Synthesis and study of 1-ethyl-3-carbohydrazide and 3-[1-oxo-2-hydrazino-3-{p-toluenesulfon}]quinolone derivatives against bacterial infections

  摘要：

  We have synthesized newer series of quinolone derivatives substituted with hydrazine group (6a-e) and sulfonamide group (7a-e). These compounds were screened for antibacterial activity. All these compounds were fully characterized by spectroscopic means and elemental analysis. From minimum inhibitory concentration (MIC) data, it has been observed that all the synthesized compounds exhibited good antibacterial activity in vitro. (C) 2013 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2013.06.056
• 作为产物：
  描述：

  6-氯-4-羟基-3-喹啉羧酸乙酯 在 potassium carbonate 、 一水合肼 作用下， 以 乙醇 、 N,N-二甲基甲酰胺 为溶剂， 反应 20.0h， 生成 6-chloro-1-ethyl-1,4-dihydro-4-oxoquinoline-3-carbohydrazide
  参考文献：
  名称：

  Synthesis and study of 1-ethyl-3-carbohydrazide and 3-[1-oxo-2-hydrazino-3-{p-toluenesulfon}]quinolone derivatives against bacterial infections

  摘要：

  We have synthesized newer series of quinolone derivatives substituted with hydrazine group (6a-e) and sulfonamide group (7a-e). These compounds were screened for antibacterial activity. All these compounds were fully characterized by spectroscopic means and elemental analysis. From minimum inhibitory concentration (MIC) data, it has been observed that all the synthesized compounds exhibited good antibacterial activity in vitro. (C) 2013 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2013.06.056