all-trans-OH-Spirilloxanthin | 16176-79-7

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: all-trans-OH-Spirilloxanthin
• 英文别名: Hydroxyspirilloxanthin；(4E,6E,8E,10E,12E,14E,16E,18E,20E,22E,24E,26E,28E)-31-methoxy-2,6,10,14,19,23,27,31-octamethyldotriaconta-4,6,8,10,12,14,16,18,20,22,24,26,28-tridecaen-2-ol
• CAS: 16176-79-7
• 化学式: C₄₁H₅₈O₂
• 分子量: 582.91
• InChiKey: SSZVJOJPPUPCBF-JARCNSDHSA-N

物化性质

• 沸点：
  714.7±43.0 °C(Predicted)
• 密度：
  0.932±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  13.3
• 重原子数：
  43
• 可旋转键数：
  17
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.37
• 拓扑面积：
  29.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  三甲基氯硅烷 、 all-trans-OH-Spirilloxanthin 在 六甲基二硅氮烷 作用下， 生成 1'-Methoxy-3,4,3',4'-tetradehydro-1,2,1',2'-tetrahydro-ψ,ψ-caroten-1-ol-trimethylsilylaether
  参考文献：
  名称：

  Monohydroxycarotenoids from diphenylamine-inhibited cultures of Rhodospirillum rubrum

  摘要：

  DOI：

  10.1016/s0031-9422(00)91297-4
• 作为产物：
  描述：

  2-Methoxy-2-methyl-pentin-(4) 生成 all-trans-OH-Spirilloxanthin
  参考文献：
  名称：

  类胡萝卜素和相关化合物。第十七部分。螺黄质，“ OH-螺黄质”和3,4-脱水hodopin的合成

  摘要：

  合成了螺旋藻黄质，“ OH-螺旋黄质”和3,4-脱水视紫红质。对于α-细菌尿黄素提出的结构已显示需要修改。

  DOI：

  10.1039/j39670001686

文献信息

• COMPOSITION FOR USE IN A METHOD FOR LOWERING OF LDL-CHOLESTEROL IN PLASMA
  申请人：ezCol B.V.

  公开号：EP3897677A1

  公开（公告）日：2021-10-27
• [EN] COMPOSITION FOR USE IN A METHOD FOR LOWERING OF LDL-CHOLESTEROL IN PLASMA<br/>[FR] COMPOSITION À UTILISER DANS UNE MÉTHODE VISANT À ABAISSER LE TAUX PLASMATIQUE DE CHOLESTÉROL LBD
  申请人：EZCOL B V

  公开号：WO2020130813A1

  公开（公告）日：2020-06-25

  The present invention relates to a (pharmaceutical) composition comprising geranyl-geranyl bacteriopheophytin a, phytyl derivative of bacteriopheophytin a, hydroxyspirilloxanthin, rhodovibrin, 3,4- rhodopin, chloroxanthin, rhodopin, spirilloxanthin, 3,4-spirilloxanthin, ubiquinol-10, ubiquinone-9, ubiquinone-10 and rhodoquinone-10, for use in a method for the lowering of LDL-cholesterol in subjects in need thereof. Furthermore, the invention relates to a foodstuff comprising a food supplement, wherein the food supplement has cholesterol-lowering properties and comprises compounds geranyl-geranyl bacteriopheophytin a, phytyl derivative of bacteriopheophytin a, hydroxyspirilloxanthin, rhodovibrin, 3,4- rhodopin, chloroxanthin, rhodopin, spirilloxanthin, 3,4-spirilloxanthin, ubiquinol-10, ubiquinone-9, ubiquinone-10 and rhodoquinone-10. For the pharmaceutical composition and the composition and the food supplement the proviso is that the (pharmaceutical) composition is not, and the compounds are not provided as, a petroleum ether extract of Rhodospirillum rubrum obtainable by extraction of Rhodospirillum rubrum cells with a mixture of petroleum ether with a boiling point of between 60°C and 80°C and methanol comprising sodium chloride, wherein the extract is obtained by extraction for between 10 minutes and 48 hours at between 8°C and 37°C, while mixing the cells with the mixture, and wherein the Rhodospirillum rubrum cells are extracted with the mixture in a volume ratio of between 10:1 and 1:10 of petroleum ether with a boiling point of between 60°C and 80°C and methanol comprising sodium chloride. Furthermore, the (pharmaceutical) composition and compounds are not comprising or provided as whole R.rubrum cells or as a membrane fraction of R.rubrum.