2-Methoxy-2-methyl-pentin-(4) | 28809-44-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-Methoxy-2-methyl-pentin-(4)
• 英文别名: 4-Methoxy-4-methyl-1-pentin；4-methoxy-4-methyl-pent-1-yne；4-Methoxy-4-methylpent-1-yne；4-methoxy-4-methylpent-1-yne
• CAS: 28809-44-1
• 化学式: C₇H₁₂O
• 分子量: 112.172
• InChiKey: IXQRAPXONRFUSX-UHFFFAOYSA-N

物化性质

• 沸点：
  118.1±23.0 °C(Predicted)
• 密度：
  0.835±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  8
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2-Methoxy-2-methyl-pentin-(4) 生成 (4E,6E,8E,10E,12E,14E,16E,18E,20E,22E,24E,26E,28E)-2,31-二甲氧基-2,6,10,14,19,23,27,31-八甲基三十二碳-4,6,8,10,12,14,16,18,20,22,24,26,28-十三烯
  参考文献：
  名称：

  类胡萝卜素和相关化合物。第十七部分。螺黄质，“ OH-螺黄质”和3,4-脱水hodopin的合成

  摘要：

  合成了螺旋藻黄质，“ OH-螺旋黄质”和3,4-脱水视紫红质。对于α-细菌尿黄素提出的结构已显示需要修改。

  DOI：

  10.1039/j39670001686
• 作为产物：
  描述：

  甲醇 、 2-chloromethylene-1,1-dimethyl-cyclopropane 在 三乙胺 作用下， 以 水 为溶剂， 反应 8.0h， 生成 2-Methoxy-2-methyl-pentin-(4)
  参考文献：
  名称：

  溶剂分解法1-氯亚甲基-2，2-二甲基环丙烷。

  摘要：

  DOI：

  10.1016/s0040-4039(01)98351-0

文献信息

• Discovery of N-substituted 7-azaindoles as Pan-PIM kinases inhibitors – Lead optimization – Part III
  作者：Claude Barberis、James Pribish、Elina Tserlin、Alexandre Gross、Mark Czekaj、Matthieu Barragué、Paul Erdman、Sachin Maniar、John Jiang、Luke Fire、Vinod Patel、Andrew Hebert、Mikhail Levit、Anlai Wang、Frank Sun、Shih-Min A. Huang

  DOI：10.1016/j.bmcl.2018.12.015

  日期：2019.2

  N-substituted azaindoles were discovered as promising pan-PIM inhibitors. Lead optimization is described en route toward the identification of a clinical candidate. Modulation of physico-chemical properties allowed to solve inherent hERG and permeability liabilities. Compound 17 showed tumor growth inhibition in a KG1 tumor-bearing mouse model.

  发现N-取代的吲哚吲哚是有希望的泛PIM抑制剂。在确定临床候选者的过程中描述了线索优化。理化性质的调节允许解决固有的hERG和渗透性负债。在具有KG1肿瘤的小鼠模型中，化合物17显示出肿瘤生长抑制作用。
• COMPOSITION FOR USE IN A METHOD FOR LOWERING OF LDL-CHOLESTEROL IN PLASMA
  申请人：ezCol B.V.

  公开号：EP3897677A1

  公开（公告）日：2021-10-27
• [EN] COMPOSITION FOR USE IN A METHOD FOR LOWERING OF LDL-CHOLESTEROL IN PLASMA<br/>[FR] COMPOSITION À UTILISER DANS UNE MÉTHODE VISANT À ABAISSER LE TAUX PLASMATIQUE DE CHOLESTÉROL LBD
  申请人：EZCOL B V

  公开号：WO2020130813A1

  公开（公告）日：2020-06-25

  The present invention relates to a (pharmaceutical) composition comprising geranyl-geranyl bacteriopheophytin a, phytyl derivative of bacteriopheophytin a, hydroxyspirilloxanthin, rhodovibrin, 3,4- rhodopin, chloroxanthin, rhodopin, spirilloxanthin, 3,4-spirilloxanthin, ubiquinol-10, ubiquinone-9, ubiquinone-10 and rhodoquinone-10, for use in a method for the lowering of LDL-cholesterol in subjects in need thereof. Furthermore, the invention relates to a foodstuff comprising a food supplement, wherein the food supplement has cholesterol-lowering properties and comprises compounds geranyl-geranyl bacteriopheophytin a, phytyl derivative of bacteriopheophytin a, hydroxyspirilloxanthin, rhodovibrin, 3,4- rhodopin, chloroxanthin, rhodopin, spirilloxanthin, 3,4-spirilloxanthin, ubiquinol-10, ubiquinone-9, ubiquinone-10 and rhodoquinone-10. For the pharmaceutical composition and the composition and the food supplement the proviso is that the (pharmaceutical) composition is not, and the compounds are not provided as, a petroleum ether extract of Rhodospirillum rubrum obtainable by extraction of Rhodospirillum rubrum cells with a mixture of petroleum ether with a boiling point of between 60°C and 80°C and methanol comprising sodium chloride, wherein the extract is obtained by extraction for between 10 minutes and 48 hours at between 8°C and 37°C, while mixing the cells with the mixture, and wherein the Rhodospirillum rubrum cells are extracted with the mixture in a volume ratio of between 10:1 and 1:10 of petroleum ether with a boiling point of between 60°C and 80°C and methanol comprising sodium chloride. Furthermore, the (pharmaceutical) composition and compounds are not comprising or provided as whole R.rubrum cells or as a membrane fraction of R.rubrum.
• Carotenoids and related compounds. Part XVII. Synthesis of spirilloxanthin, “OH-spirilloxanthin,” and 3,4-dehydrorhodopin
  作者：D. F. Schneider、B. C. L. Weedon

  DOI：10.1039/j39670001686

  日期：——

  Spirilloxanthin, “OH-spirilloxanthin,” and 3,4-dehydrorhodopin have been synthesised. The structure proposed for α-bacterioruberin has been shown to require revision.

  合成了螺旋藻黄质，“ OH-螺旋黄质”和3,4-脱水视紫红质。对于α-细菌尿黄素提出的结构已显示需要修改。
• Solvolyse des 1-Chlormethylen-2,2-dimethylcyclopropans.
  作者：Aurelia Ghenciulescu、Michael Hanack

  DOI：10.1016/s0040-4039(01)98351-0

  日期：1970.1