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5-氨基-2-甲氧基苯甲酸甲酯 | 22802-67-1

中文名称
5-氨基-2-甲氧基苯甲酸甲酯
中文别名
——
英文名称
methyl 2-methoxy-5-aminobenzoate
英文别名
methyl 5-amino-2-methoxybenzoate;5-amino-2-methoxybenzoic acid methyl ester
5-氨基-2-甲氧基苯甲酸甲酯化学式
CAS
22802-67-1
化学式
C9H11NO3
mdl
——
分子量
181.191
InChiKey
PSCXCIPPRCFAAO-UHFFFAOYSA-N
BEILSTEIN
——
EINECS
——
  • 物化性质
  • 计算性质
  • ADMET
  • 安全信息
  • SDS
  • 制备方法与用途
  • 上下游信息
  • 反应信息
  • 文献信息
  • 表征谱图
  • 同类化合物
  • 相关功能分类
  • 相关结构分类

物化性质

  • 沸点:
    329.6±22.0 °C(Predicted)
  • 密度:
    1.179±0.06 g/cm3(Predicted)

计算性质

  • 辛醇/水分配系数(LogP):
    1.4
  • 重原子数:
    13
  • 可旋转键数:
    3
  • 环数:
    1.0
  • sp3杂化的碳原子比例:
    0.22
  • 拓扑面积:
    61.6
  • 氢给体数:
    1
  • 氢受体数:
    4

安全信息

  • 海关编码:
    2922509090
  • 危险性防范说明:
    P261,P305+P351+P338
  • 危险性描述:
    H315,H319,H335
  • 储存条件:
    储存温度:2-8℃,需保存在惰性气体中。

SDS

SDS:2820ae5ed98b5423bbabe058768990ee
查看
Material Safety Data Sheet

Section 1. Identification of the substance
Product Name: Methyl 5-amino-2-methoxybenzoate
Synonyms:

Section 2. Hazards identification
Harmful by inhalation, in contact with skin, and if swallowed.

Section 3. Composition/information on ingredients.
Ingredient name: Methyl 5-amino-2-methoxybenzoate
CAS number: 22802-67-1

Section 4. First aid measures
Skin contact: Immediately wash skin with copious amounts of water for at least 15 minutes while removing
contaminated clothing and shoes. If irritation persists, seek medical attention.
Eye contact: Immediately wash skin with copious amounts of water for at least 15 minutes. Assure adequate
flushing of the eyes by separating the eyelids with fingers. If irritation persists, seek medical
attention.
Inhalation: Remove to fresh air. In severe cases or if symptoms persist, seek medical attention.
Ingestion: Wash out mouth with copious amounts of water for at least 15 minutes. Seek medical attention.

Section 5. Fire fighting measures
In the event of a fire involving this material, alone or in combination with other materials, use dry
powder or carbon dioxide extinguishers. Protective clothing and self-contained breathing apparatus
should be worn.

Section 6. Accidental release measures
Personal precautions: Wear suitable personal protective equipment which performs satisfactorily and meets local/state/national
standards.
Respiratory precaution: Wear approved mask/respirator
Hand precaution: Wear suitable gloves/gauntlets
Skin protection: Wear suitable protective clothing
Eye protection: Wear suitable eye protection
Methods for cleaning up: Mix with sand or similar inert absorbent material, sweep up and keep in a tightly closed container
for disposal. See section 12.
Environmental precautions: Do not allow material to enter drains or water courses.

Section 7. Handling and storage
Handling: This product should be handled only by, or under the close supervision of, those properly qualified
in the handling and use of potentially hazardous chemicals, who should take into account the fire,
health and chemical hazard data given on this sheet.
Store in closed vessels.
Storage:

Section 8. Exposure Controls / Personal protection
Engineering Controls: Use only in a chemical fume hood.
Personal protective equipment: Wear laboratory clothing, chemical-resistant gloves and safety goggles.
General hydiene measures: Wash thoroughly after handling. Wash contaminated clothing before reuse.

Section 9. Physical and chemical properties
Appearance: Not specified
Boiling point: No data
No data
Melting point:
Flash point: No data
Density: No data
Molecular formula: C9H11NO3
Molecular weight: 181.2

Section 10. Stability and reactivity
Conditions to avoid: Heat, flames and sparks.
Materials to avoid: Oxidizing agents.
Possible hazardous combustion products: Carbon monoxide, nitrogen oxides.

Section 11. Toxicological information
No data.

Section 12. Ecological information
No data.

Section 13. Disposal consideration
Arrange disposal as special waste, by licensed disposal company, in consultation with local waste
disposal authority, in accordance with national and regional regulations.

Section 14. Transportation information
Non-harzardous for air and ground transportation.

Section 15. Regulatory information
No chemicals in this material are subject to the reporting requirements of SARA Title III, Section
302, or have known CAS numbers that exceed the threshold reporting levels established by SARA
Title III, Section 313.


SECTION 16 - ADDITIONAL INFORMATION
N/A

上下游信息

  • 上游原料
    中文名称 英文名称 CAS号 化学式 分子量
  • 下游产品
    中文名称 英文名称 CAS号 化学式 分子量
    • 1
    • 2

反应信息

  • 作为反应物:
    参考文献:
    名称:
    (3-Substituted benzyl)thiazolidine-2,4-diones as structurally new antihyperglycemic agents
    摘要:
    A series of 3-[(2,4-dioxothiazolidin-5-yl)methyl]benzamide derivatives was prepared as part of a search for antidiabetic agents. A structure-activity relationship study of these compounds led to the identification of 5-[(2,4-dioxothiazolidin-5-yl)methyl] -2-methoxy-N-[[4-trifluoromethyl)phenyl]methyl]benzamide (KRP-297) as a candidate drug for the treatment of diabetes mellitus. (C) 1999 Elsevier Science Ltd. All rights reserved.
    DOI:
    10.1016/s0960-894x(99)00039-6
  • 作为产物:
    描述:
    5-甲基水杨酸硫酸potassium tert-butylate 作用下, 以 二甲基亚砜 为溶剂, 反应 2.08h, 生成 5-氨基-2-甲氧基苯甲酸甲酯
    参考文献:
    名称:
    Multitarget Compounds Active at a PPAR and Cannabinoid Receptor
    摘要:
    需要具有至少一种PPAR和大麻受体活性的药物化合物。因此提供了这样的化合物,其中该化合物包括:由包含一个五元环与一个六元环或一个六元环与一个六元环融合的融合双环环的基团连接在一起的PPAR药效团和大麻药效团;其中大麻药效团包括融合双环环;而PPAR药效团包括水杨酸、烷氧基苯乙酸或烷氧基苯乙酸官能团;PPAR药效团通过包含胺基或酰胺官能团的连接物连接到大麻药效团的双环环上。
    公开号:
    US20110039808A1
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文献信息

  • [EN] VIRAL POLYMERASE INHIBITORS<br/>[FR] INHIBITEURS DE POLYMERASE VIRALE
    申请人:BOEHRINGER INGELHEIM INT
    公开号:WO2004065367A1
    公开(公告)日:2004-08-05
    An isomer, enantiomer, diastereoisomer or tautomer of a compound, represented by formula (I): wherein wherein A, B, R2, R3, L, M1, M2, M3, M4, Y1, Y0, Z and Sp are as defined in claim 1, or a salt thereof, as an inhibitor of HCV NS5B polymerase.
    化合物的异构体、对映体、非对映异构体或互变异构体,由式(I)所代表:其中A、B、R2、R3、L、M1、M2、M3、M4、Y1、Y0、Z和Sp如权利要求1中定义,或其盐,作为HCV NS5B聚合酶的抑制剂。
  • Conversion of Aromatic Amino into Trifluoromethyl Groups through a Sandmeyer­-Type Transformation
    作者:Jianbo Wang、Xi Wang、Yan Xu、Yujing Zhou、Yan Zhang
    DOI:10.1055/s-0033-1338659
    日期:——
    strategy for aromatic trifluoromethylation by converting amino into trifluoromethyl groups via a Sandmeyer-type reaction is reported. The transformation involves diazotization of the aromatic amines with tert-butyl nitrite and hydrochloric acid to form aryldiazonium chlorides, followed by trifluoromethylation with trifluoromethylsilver at low temperature. Various readily available aromatic amines are
    摘要 报道了通过Sandmeyer型反应将氨基转化为三氟甲基的芳香族三氟甲基化的新策略。该转化包括用亚硝酸叔丁酯和盐酸将芳族胺重氮化以形成芳基重氮氯化物,然后在低温下用三氟甲基银进行三氟甲基化。各种容易获得的芳族胺在温和条件下均能平稳转化。 报道了通过Sandmeyer型反应将氨基转化为三氟甲基的芳香族三氟甲基化的新策略。该转化包括用亚硝酸叔丁酯和盐酸将芳族胺重氮化以形成芳基重氮氯化物,然后在低温下用三氟甲基银进行三氟甲基化。各种容易获得的芳族胺在温和条件下均能平稳转化。
  • Carboxysubstituted cyclic carboxamide derivatives
    申请人:Hoechst Marion Roussel, Inc.
    公开号:US05977139A1
    公开(公告)日:1999-11-02
    The present invention relates to novel carboxy substituted cyclic carboxamide derivatives of formula (1), ##STR1## and stereoisomers and pharmaceutically acceptable salts thereof and their use as tachykinin receptor antagonists. Such antagonists are useful in the treatment of tachykinin-mediated diseases and conditions disclosed herein including: asthma, coughs and bronchitis.
    本发明涉及新型的带有羧基取代的环戊酰胺衍生物,化学式为(1),##STR1##及其立体异构体和药学上可接受的盐,以及它们作为速激肽受体拮抗剂的用途。这类拮抗剂在治疗包括哮喘、咳嗽和支气管炎在内的速激肽介导的疾病和症状中很有用。
  • QUINOLINE DERIVATIVES
    申请人:Jung Frederic Henri
    公开号:US20090076075A1
    公开(公告)日:2009-03-19
    The invention concerns quinoline derivatives of Formula I or a pharmaceutically-acceptable salt thereof, wherein each of X 1 , p, R 1 , q, R 2 , R 3 , R 4 , R 5 Ring A, r and R 6 has any of the meanings defined hereinbefore in the description; processes for their preparation, pharmaceutical compositions containing them and their use in the manufacture of a medicament for use in the treatment of cell proliferative disorders.
    这项发明涉及公式I的喹啉衍生物或其药用盐,其中X 1 ,p,R 1 ,q,R 2 ,R 3 ,R 4 ,R 5 ,环A,r和R 6 中的每一个具有在描述中定义的任何含义;它们的制备方法,含有它们的药物组合物以及它们在制造用于治疗细胞增殖紊乱的药物的药物中的使用。
  • Substituted N-methyl-N-(4-(4-(1H-benzimidazol-2-yl)
    申请人:Hoechst Marion Roussel, Inc.
    公开号:US05932571A1
    公开(公告)日:1999-08-03
    The present invention relates to novel N-methyl-N-(4-(4-(1H-benzimidazol-2-yl)\x9b1,4!diazepan-1-yl)-2-(aryl)butyl)b enzamide derivatives of the formula: ##STR1## stereoisomers thereof, and pharmaceutically acceptable salts thereof which are useful as histamine receptor antagonists and tachykinin receptor antagonists. Such antagonists are useful in the treatment of allergic rhinitis, including seasonal rhinitis and sinusitis; inflammatory bowel diseases, including Crohn's disease and ulcerative colitis; asthma; bronchitis; and emesis.
    本发明涉及新型N-甲基-N-(4-(4-(1H-苯并咪唑-2-基)\x9b1,4!二氮杂环己烷-1-基)-2-(芳基)丁基)苯酰胺衍生物的公式:##STR1## 其立体异构体,以及其药学上可接受的盐,可用作组胺受体拮抗剂和速激肽受体拮抗剂。这类拮抗剂在过敏性鼻炎的治疗中很有用,包括季节性鼻炎和鼻窦炎;炎症性肠病,包括克罗恩病和溃疡性结肠炎;哮喘;支气管炎;以及呕吐。
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