16,17-dimethoxy-5,7-dioxa-13-azoniapentacyclo[11.8.0.02,10.04,8.015,20]henicosa-1(13),2,4(8),9,14,16,18,20-octaene

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 原小檗碱生物碱及其衍生物
• 英文名称: 16,17-dimethoxy-5,7-dioxa-13-azoniapentacyclo[11.8.0.02,10.04,8.015,20]henicosa-1(13),2,4(8),9,14,16,18,20-octaene
• 化学式: C40H36N2O8+2
• 分子量: 672.7
• InChiKey: RMQDOUJEWBRXRA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.19
• 重原子数：
  50
• 可旋转键数：
  4
• 环数：
  10.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  81.6
• 氢给体数：
  0
• 氢受体数：
  8

文献信息

• COMPOSITIONS, METHODS AND USES FOR THE TREATMENT OF DIABETES AND RELATED CONDITIONS BY CONTROLLING BLOOD GLUCOSE LEVEL
  申请人：Pharnext

  公开号：EP2914252A1

  公开（公告）日：2015-09-09
• COMPOSITIONS, METHODS AND USES FOR THE TREATMENT OF DIABETIC NEUROPATHIES
  申请人：Pharnext

  公开号：EP3137065A2

  公开（公告）日：2017-03-08
• BERBERINE ALKALOIDS IN THE PREVENTION AND/OR TREATMENT OF INTESTINAL DISEASE
  申请人：IRP Health Pty Ltd

  公开号：EP3600304A1

  公开（公告）日：2020-02-05
• [EN] COMPOSITIONS, METHODS AND USES FOR THE TREATMENT OF DIABETES AND RELATED CONDITIONS BY CONTROLLING BLOOD GLUCOSE LEVEL<br/>[FR] COMPOSITIONS, PROCÉDÉS ET UTILISATIONS POUR LE TRAITEMENT DU DIABÈTE ET D'ÉTATS ASSOCIÉS EN RÉGULANT LE NIVEAU DE GLYCÉMIE
  申请人：PHARNEXT

  公开号：WO2014068007A1

  公开（公告）日：2014-05-08

  The present invention relates to compositions and methods for controlling glycaemia in a mammalian in need thereof. The present invention relates to compositions and methods for the treatment of diabetes disease and related disorders. More specifically, the present invention relates to novel therapies or combinatorial therapies of diabetes and related disorders, based on compositions controlling the blood glucose level.
• [EN] COMPOSITIONS, METHODS AND USES FOR THE TREATMENT OF DIABETES AND RELATED CONDITIONS BY CONTROLLING BLOOD GLUCOSE LEVEL<br/>[FR] COMPOSITIONS, PROCÉDÉS ET UTILISATIONS POUR LE TRAITEMENTS DE DIABÈTE ET D'ÉTATS ASSOCIÉS EN RÉGULANT LE NIVEAU DE GLYCÉMIE
  申请人：PHARNEXT

  公开号：WO2015063140A1

  公开（公告）日：2015-05-07

  The present invention relates to compositions and methods for controlling glycaemia in a mammalian in need thereof. The present invention relates to compositions and methods for the treatment of diabetes disease and related disorders. More specifically, the present invention relates to novel therapies or combinatorial therapies of diabetes and related disorders, based on compositions controlling the blood glucose level.